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WORLD CLASS S&T UNIVERSITY

Academics

College of Life Science and Bioengineering

With the specialization of biology, brain science, medical science, and IT/NT, KAIST has accumulated academic capability in the area of biology. The College of Life Science and Bioengineering was founded to efficiently support the fusion research environment of KI for Biocentury at KAIST.

The College of Life Science and Bioengineering is composed of the Department of Biological Sciences, Department of Bio & Brain Engineering, and Graduate School of Medical Science & Engineering. The college pursues multidisciplinary education & research in the area of biology and the development of modern science through the fusion of the IT & NT foundation techniques for the development of the nation’s biological science and technology.

The Department of Biological Sciences fosters scientists and engineers of life science and biotechnology equipped with creative research skills to lead in the development of science and technology in the area of biological sciences and excellent scientists equipped with future oriented thinking and a holistic personality.

The multidisciplinary Department of Bio & Brain Engineering fosters a creative workforce that is capable of creating new knowledge and techniques in the fusion areas of electronics, computers, and nanotechnology based on biomedical science.

The Graduate School of Medical Science & Engineering is catered to doctors (specialists), graduates from medical schools, dental schools, and schools of oriental medicine for the development of new medicine and medical devices. The Graduate School of Medical Science & Engineering was established with the purpose of developing life sciences and medical technology and fostering a high-quality workforce equipped with a multidisciplinary knowledge in basic medicine, life science, and biomedical engineering, as well as research experience.

Academic Degree Curriculum
Academic Degree Curriculum
Department/Major Bachelor's Courses Master's Courses Doctoral Courses Office of Academic Affairs Website
Department of Biological Sciences
042-350-2602(F.2610) Homepage go
Graduate School of Medical Science and Engineering
  042-350-4232(F.4240) Homepage go
Interdisciplinary Majors and Educational Programs
Education Program
College
(Department/Major)
Interdisciplinary Majors and Educational Programs Bachelor's Courses Master's Courses Doctoral Courses Office of Academic Affairs Website
Graduate School of Medical Science and Engineering
Biomedical Science and Engineering
Interdisciplinary Program
  042-350-4232(F.4240) Homepage go
※ Department of Bio and Brain Engineering is changed of affiliation from College of Life Science and Bioengineering to College of Engineering on March 1st, 2015.
KAIST COMPASS in Life Science & Bioengineering
2018 Spring Dietary-mediated ROS generation in macrophage Paradigm shift in a classic neuroscience model Bystander Activation of T-Cells during Viral Infection Inducing of Neuron-Specific Nucleosome BAF53b upon Fear Learning Discovery of “crosstalk” towards the prevention of fatty liver development 2017 Fall Archeological traces of embryo development in adult Architecture of a gatekeeper translocating Structural determinations shed light on MDGA Overturning conventional thinking in Parkinson’s ATP-dependent chromatin remodeler Ino80 replaces
News
 
Potential Drug to Cure Ciliopathies


from left: Professor Joon Kim and PhD candidate Yong Joon Kim
(from left: Professor Joon Kim and PhD candidate Yong Joon Kim)

Ciliopathies are rare disorders involving functional and structural abnormalities of cilia. Although they are rare, they may reach 1 in 1,000 births. Unfortunately, there are no small-molecule drugs for treating ciliary defects. A KAIST research team conducted successful research that introduces a potential treatment that will be a foundation for developing drugs to treat the disease as well as a platform for developing small-molecule drugs for similar genetic disorders.

 

It was found that mutations in genes required for the formation or function of primary cilia cause ciliopathies and they result in cerebellar disorders, kidney dysfunction, and retinal degeneration.

 

Primary cilia are cell organelles playing a crucial role in the human body. They participate in intercellular signal transduction during embryonic development and allow retinal photoreceptor cells to function.


Currently, there are no approved drugs available for treating most ciliopathies. In fact, this is the case for most of the rare genetic disorders involving functional abnormalities through genetic mutation, and gene therapy is usually the only treatment available.


To tackle this issue, a team led by Professor Joon Kim from the Graduate School of Medical Science and Engineering and Ho Jeong Kwon from Yonsei University constructed a cell that mimics a gene-mutated CEP290, one of the main causes of ciliopathies, through genome editing. They then used cell-based compound library screening to obtain a natural small-molecule compound capable of relieving defects in ciliogenesis, the production of cilia.

 

The CEP290 protein forms a complex with a ciliopathy protein called NPHP5 to support the function of the ciliary transition zone. In cases where the CEP290 protein is not formed due to a genetic mutation, NPHP5 will not function normally. Here, the compound was confirmed to partially restore the function of the complex by normalizing the function of NPHP5.

 

The team also identified that the compound is capable of retarding retinal degeneration by injecting the compound into animal models.

 

As a result, they discovered a lead compound for developing medication to treat ciliopathy patients involving retinal degeneration. Hence, the findings imply that chemical compounds that target other proteins interacting with the disease protein can mitigate shortages of a disease protein in recessive genetic disorders.


PhD candidate Yong Joon Kim stated, “This study shows how genetic disorders caused by genetic mutation can be treated with small-molecule drugs.”

 

Professor Kim said, “Since the efficacy of the candidate drug has been verified through animal testing, a follow-up study will also be conducted to demonstrate the effect on humans.”


This research was published in the Journal of Clinical Investigation on July 23.

 

 

Figure 1. Identification of compounds that rescue ciliogenesis defects caused by CEP290 knockout
Figure 1. Identification of compounds that rescue ciliogenesis defects caused by CEP290 knockout

Figure 2. Eupatilin injection ameliorates M-opsin trafficking and electrophysiological response of cone photoreceptors in rd16 mice
Figure 2. Eupatilin injection ameliorates M-opsin trafficking and electrophysiological
response of cone photoreceptors in rd16 mice

Newsletter
Department of Biological Sciences KAIST COMPASS
Contact Information for the College of Life Science and Bioengineering: 042-350-ext.

Office of the Dean of the College of Life Science and Bioengineering: 2125
College of Life Science and Bioengineering Academic and Student Affairs Team: 1401, 1409, Fax: 1400

KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

T. 042-350-2114 / F. 042-350-2210 (2220)

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