medical+engineering
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An intravenous needle that irreversibly softens via body temperature on insertion
- A joint research team at KAIST developed an intravenous (IV) needle that softens upon insertion, minimizing risk of damage to blood vessels and tissues.
- Once used, it remains soft even at room temperature, preventing accidental needle stick injuries and unethical multiple use of needle.
- A thin-film temperature sensor can be embedded with this needle, enabling real-time monitoring of the patient's core body temperature, or detection of unintended fluid leakage, during IV medication.
Intravenous (IV) injection is a method commonly used in patient’s treatment worldwide as it induces rapid effects and allows treatment through continuous administration of medication by directly injecting drugs into the blood vessel. However, medical IV needles, made of hard materials such as stainless steel or plastic which do not mechanically match the soft biological tissues of the body, can cause critical problems in healthcare settings, starting from minor tissue damages in the injection sites to serious inflammations.
The structure and dexterity of rigid medical IV devices also enable unethical reuse of needles for reduction of injection costs, leading to transmission of deadly blood-borne disease infections such as human immunodeficiency virus (HIV) and hepatitis B/C viruses. Furthermore, unintended needlestick injuries are frequently occurring in medical settings worldwide, that are viable sources of such infections, with IV needles having the greatest susceptibility of being the medium of transmissible diseases. For these reasons, the World Health Organization (WHO) in 2015 launched a policy on safe injection practices to encourage the development and use of “smart” syringes that have features to prevent re-use, after a tremendous increase in the number of deadly infectious disease worldwide due to medical-sharps related issues.
KAIST announced on the 13th that Professor Jae-Woong Jeong and his research team of its School of Electrical Engineering succeeded in developing the Phase-Convertible, Adapting and non-REusable (P-CARE) needle with variable stiffness that can improve patient health and ensure the safety of medical staff through convergent joint research with another team led by Professor Won-Il Jeong of the Graduate School of Medical Sciences.
The new technology is expected to allow patients to move without worrying about pain at the injection site as it reduces the risk of damage to the wall of the blood vessel as patients receive IV medication. This is possible with the needle’s stiffness-tunable characteristics which will make it soft and flexible upon insertion into the body due to increased temperature, adapting to the movement of thin-walled vein. It is also expected to prevent blood-borne disease infections caused by accidental needlestick injuries or unethical re-using of syringes as the deformed needle remains perpetually soft even after it is retracted from the injection site.
The results of this research, in which Karen-Christian Agno, a doctoral researcher of the School of Electrical Engineering at and Dr. Keungmo Yang of the Graduate School of Medical Sciences participated as co-first authors, was published in Nature Biomedical Engineering on October 30. (Paper title: A temperature-responsive intravenous needle that irreversibly softens on insertion)
< Figure 1. Disposable variable stiffness intravenous needle. (a) Conceptual illustration of the key features of the P-CARE needle whose mechanical properties can be changed by body temperature, (b) Photograph of commonly used IV access devices and the P-CARE needle, (c) Performance of common IV access devices and the P-CARE needle >
“We’ve developed this special needle using advanced materials and micro/nano engineering techniques, and it can solve many global problems related to conventional medical needles used in healthcare worldwide”, said Jae-Woong Jeong, Ph.D., an associate professor of Electrical Engineering at KAIST and a lead senior author of the study.
The softening IV needle created by the research team is made up of liquid metal gallium that forms the hollow, mechanical needle frame encapsulated within an ultra-soft silicone material. In its solid state, gallium has sufficient hardness that enables puncturing of soft biological tissues. However, gallium melts when it is exposed to body temperature upon insertion, and changes it into a soft state like the surrounding tissue, enabling stable delivery of the drug without damaging blood vessels. Once used, a needle remains soft even at room temperature due to the supercooling phenomenon of gallium, fundamentally preventing needlestick accidents and reuse problems.
Biocompatibility of the softening IV needle was validated through in vivo studies in mice. The studies showed that implanted needles caused significantly less inflammation relative to the standard IV access devices of similar size made of metal needles or plastic catheters. The study also confirmed the new needle was able to deliver medications as reliably as commercial injection needles.
< Photo 1. Photo of the P-CARE needle that softens with body temperature. >
Researchers also showed possibility of integrating a customized ultra-thin temperature sensor with the softening IV needle to measure the on-site temperature which can further enhance patient’s well-being. The single assembly of sensor-needle device can be used to monitor the core body temperature, or even detect if there is a fluid leakage on-site during indwelling use, eliminating the need for additional medical tools or procedures to provide the patients with better health care services.
The researchers believe that this transformative IV needle can open new opportunities for wide range of applications particularly in clinical setups, in terms of redesigning other medical needles and sharp medical tools to reduce muscle tissue injury during indwelling use. The softening IV needle may become even more valuable in the present times as there is an estimated 16 billion medical injections administered annually in a global scale, yet not all needles are disposed of properly, based on a 2018 WHO report.
< Figure 2. Biocompatibility test for P-CARE needle: Images of H&E stained histology (the area inside the dashed box on the left is provided in an expanded view in the right), TUNEL staining (green), DAPI staining of nuclei (blue) and co-staining (TUNEL and DAPI) of muscle tissue from different organs. >
< Figure 3. Conceptual images of potential utilization for temperature monitoring function of P-CARE needle integrated with a temperature sensor. >
(a) Schematic diagram of injecting a drug through intravenous injection into the abdomen of a laboratory mouse (b) Change of body temperature upon injection of drug (c) Conceptual illustration of normal intravenous drug injection (top) and fluid leakage (bottom) (d) Comparison of body temperature during normal drug injection and fluid leakage: when the fluid leak occur due to incorrect insertion, a sudden drop of temperature is detected.
This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT.
2023.11.13 View 10899 -
NYC-KAIST Cooperation Agreement Signed in New York for KAIST NYU Joint Campus
A ceremony was held to celebrate the signing of the Cooperative Agreement between NYC and KAIST and the presentation of the signage for KAIST NYU Joint Campus at NYU’s Kimmel Center in Manhattan.
KAIST President Kwang Hyung Lee (left) and NYU President Andrew Hamilton (right)
KAIST (President Kwang Hyung Lee) signed a cooperative agreement with the City of New York and had an official showing of the signage for the Joint Campus of KAIST and New York University (NYU) on September 21 at 4:00 pm (Eastern Standard Time) at NYU’s Kimmel Center in New York City with the NYC Mayor Eric Adams, the Korean Minister of Science and ICT Dr. Lee Jong-ho, NYU Chairman William Berkley, NYU President Andrew Hamilton, and other distinguished guests in attendance.
KAIST and NYU signed a Memorandum of Understanding in June about building a joint campus in an effort to educate global talent. As a follow-up measure, NYU has provided KAIST with space to begin joint research programs and held a ceremony to present the signage designed for the future KAIST NYU Campus. In line with these efforts, KAIST has also signed an agreement with New York City, the administrative authority in charge of the establishment of the campus, for mutual cooperation.
NYU is a prestigious university headquartered in Manhattan, New York. It has nurtured outstanding talents in the humanities, art, and basic sciences, including 38 Nobel Prize winners, 5 Fields Prize winners, 26 Pulitzer Prize winners, and 38 Academy Award winners to be deserving of the evaluation.
The proposed joint campus is to be centered on science, technology, engineering, and mathematics (STEM) by combining NYU's excellent basic sciences and convergence research capabilities with KAIST's globally renowned science and technology capabilities. The joint initiative is expected to launch in 2023; its programs will focus on areas such as AI Basic Science, AI Convergence Brain Science, AI-Applied Cyber Security, Cyber Security, and Sustainable High-Tech Smart City/Climate Change in order to lead the Digital Era and to solve the problems that surfaced following the COVID-19 pandemic. In addition, in order to prepare for the Post-AI Era, it was decided to create the “New Engineering” program for undergraduate program that employs a hyper-convergence learning model that combines project-based, problem-solving learning (PBL, PSL) pedagogy.
▲ Biomedical Engineering- Research and development of technology to respond to the entire cycle (prevention-treatment-diagnosis-prediction) for a new infectious disease (Disease X) by converging new technologies such as IT and NT with biomedical technologies
▲ AI Convergence Neuroscience- Research on brain-machine interaction and brain-based machine learning through AI technology convergence
▲ AI Science- Algorithm development and in-depth research in preparation for the post AI era
▲ Sustainability and Climate Change- R&DB for advanced smart cities, sustainability for the global environment and carbon zero
▲ Next-generation Wireless Communications- From ICT to AIT: Research on 6G/7G related technologies, new communications theories, and etc.
▲ Cyber Security- Advanced research on protection of digital information and information safety/reliability
KAIST President Kwang Hyung Lee (left) and NYC Mayor Eric Adams (right)
The KAIST NYU Joint Campus has started enlisting professors and researchers from both institutions to participate in the collaboration. The campus will also function as the headquarter that will oversee the operation of the joint research program. At Daejeon, KAIST is also setting up a location for NYU on its main campus to provide space for NYU researchers upon their visit to KAIST.
The KAIST NYU Joint Campus, which has begun to take basic shape with the space for collaboration rendered this time, is to be upgraded to “KAIST New York Campus” in the future to function also as an industry-academic cooperation campus in which that promotes strategic cooperation with industries and expands start-up opportunities. To this end, the related procedures from the detailing of the establishment plans through a preliminary feasibility studies, to deliberation and decision on whether to proceed with the establishment by the KAIST Board of Trustees, will be taken.
The KAIST NYU Campus is expected to serve as a stepping stone for the outstanding talents of KAIST to pursue their dreams in the global market and research environment while seizing the attention of the world-class talents drawn to New York at the same time. In addition, by combining NYU's strong basic academic capabilities with KAIST’s strengths, it is expected to contribute to achieving 'global innovation' by creating synergies in various fields such as education, research, and entrepreneurship. The future KAIST-NYU Campus is also expected to encompass an industry-academic cooperation campus with industrial partners and startups.
Meanwhile, KAIST is planning to expand its excellent scientific and technological capabilities to the global stage through the cooperative agreement with New York City, and to prepare a pathway for KAIST students, faculty, and startups to enter their respective fields in the global markets. In the future, KAIST plans to explore areas of cooperation in different fields, such as education, economy, society, and culture, to prepare and implement detailed cooperation plans.
< KAIST-New York City Cooperation Items (Example) >
▲ Education: Joint degree program with a university in New York City, training of key talents in the field of artificial intelligence, etc.
▲ Economy: A hub for technology startups, job creation in the tech sector, etc.
▲ Society: Economics, finance, media-related engineering research, etc.
▲ Culture: Diversity-based culture and art-tech research, etc.▲ Etc: Joint research in the field of artificial intelligence healthcare, etc.
As a global mecca for startups, education, and investment, New York has a well-developed global network for cultural diversity and successful career development, and has great power to attract various resources including funds and talented individuals. Based on this, it has established itself as a mecca of global tech companies and global top media groups, and is building the reputation as 'Silicon Alley' in addition to its legends of the ‘Wall Street'.
Dr. Andrew Hamilton, the president of NYU, said, “We’re delighted by our newly established partnership with KAIST. We see great potential in the opportunities to collaborate on development of courses, research, cutting edge technologies, university-level courses, degrees, entrepreneurship initiatives and industrial partnerships, and exchanges. We believe this partnership is very much in line with NYU’s commitment to global engagement and will make important contributions to New York’s tech sector. It’s exciting to think how much NYU and KAIST have much to learn from one another, and how much we may accomplish together.”
New York City Mayor Eric Adams said, “We’re proud to have helped facilitate this partnership between KAIST and New York University, which will be a real win for students and help drive continued innovation in our city.” He added, “From the time that senior members of our administration learned about this opportunity during a recent trip to South Korea, we have worked closely with KAIST to develop strategies for increasing their presence and investments in New York. This is the start of a relationship that I am confident will bring even more academic, business, and technological opportunities to the five boroughs.”
Dr. Kwang Hyung Lee, the president of KAIST, urged, “Based on the KAIST-NYU partnership, we must create an interdisciplinary hyper-convergence model of collaboration and use cutting-edge tools to create an innovative model for new type of problem-solving engineering education to prepare to solve the challenges facing the world.” He went on to stress, “The new fusion engineering degree program will leverage the unique strengths of the two institutions to provide a uniquely colored education not found anywhere else.” In addition, he added, “KAIST will utilize the advantages that are unique to the global city of New York to contribute to advancing the science and technology research in New York City and creating jobs in the tech sector to lead the renaissance of Silicon Alley.”
2022.09.27 View 15524 -
Professor Jae-Woong Jeong Receives Hyonwoo KAIST Academic Award
Professor Jae-Woong Jeong from the School of Electrical Engineering was selected for the Hyonwoo KAIST Academic Award, funded by the HyonWoo Cultural Foundation (Chairman Soo-il Kwak, honorary professor at Seoul National University Business School).
The Hyonwoo KAIST Academic Award, presented for the first time in 2021, is an award newly founded by the donations of Chairman Soo-il Kwak of the HyonWoo Cultural Foundation, who aims to reward excellent KAIST scholars who have made outstanding academic achievements.
Every year, through the strict evaluations of the selection committee of the HyonWoo Cultural Foundation and the faculty reward recommendation board, KAIST will choose one faculty member that may represent the school with their excellent academic achievement, and reward them with a plaque and 100 million won.
Professor Jae-Woong Jeong, the winner of this year’s award, developed the first IoT-based wireless remote brain neural network control system to overcome brain diseases, and has been leading the field. The research was published in 2021 in Nature Biomedical Engineering, one of world’s best scientific journals, and has been recognized as a novel technology that suggested a new vision for the automation of brain research and disease treatment. This study, led by Professor Jeong’s research team, was part of the KAIST College of Engineering Global Initiative Interdisciplinary Research Project, and was jointly studied by Washington University School of Medicine through an international research collaboration. The technology was introduced more than 60 times through both domestic and international media, including Medical Xpress, MBC News, and Maeil Business News.
Professor Jeong has also developed a wirelessly chargeable soft machine for brain transplants, and the results were published in Nature Communications. He thereby opened a new paradigm for implantable semi-permanent devices for transplants, and is making unprecedented research achievements.
2022.06.13 View 10606 -
Scientists Develop Wireless Networks that Allow Brain Circuits to Be Controlled Remotely through the Internet
Wireless implantable devices and IoT could manipulate the brains of animals from anywhere around the world due to their minimalistic hardware, low setup cost, ease of use, and customizable versatility
A new study shows that researchers can remotely control the brain circuits of numerous animals simultaneously and independently through the internet. The scientists believe this newly developed technology can speed up brain research and various neuroscience studies to uncover basic brain functions as well as the underpinnings of various neuropsychiatric and neurological disorders.
A multidisciplinary team of researchers at KAIST, Washington University in St. Louis, and the University of Colorado, Boulder, created a wireless ecosystem with its own wireless implantable devices and Internet of Things (IoT) infrastructure to enable high-throughput neuroscience experiments over the internet. This innovative technology could enable scientists to manipulate the brains of animals from anywhere around the world. The study was published in the journal Nature Biomedical Engineering on November 25
“This novel technology is highly versatile and adaptive. It can remotely control numerous neural implants and laboratory tools in real-time or in a scheduled way without direct human interactions,” said Professor Jae-Woong Jeong of the School of Electrical Engineering at KAIST and a senior author of the study. “These wireless neural devices and equipment integrated with IoT technology have enormous potential for science and medicine.”
The wireless ecosystem only requires a mini-computer that can be purchased for under $45, which connects to the internet and communicates with wireless multifunctional brain probes or other types of conventional laboratory equipment using IoT control modules. By optimally integrating the versatility and modular construction of both unique IoT hardware and software within a single ecosystem, this wireless technology offers new applications that have not been demonstrated before by a single standalone technology. This includes, but is not limited to minimalistic hardware, global remote access, selective and scheduled experiments, customizable automation, and high-throughput scalability.
“As long as researchers have internet access, they are able to trigger, customize, stop, validate, and store the outcomes of large experiments at any time and from anywhere in the world. They can remotely perform large-scale neuroscience experiments in animals deployed in multiple countries,” said one of the lead authors, Dr. Raza Qazi, a researcher with KAIST and the University of Colorado, Boulder. “The low cost of this system allows it to be easily adopted and can further fuel innovation across many laboratories,” Dr. Qazi added.
One of the significant advantages of this IoT neurotechnology is its ability to be mass deployed across the globe due to its minimalistic hardware, low setup cost, ease of use, and customizable versatility. Scientists across the world can quickly implement this technology within their existing laboratories with minimal budget concerns to achieve globally remote access, scalable experimental automation, or both, thus potentially reducing the time needed to unravel various neuroscientific challenges such as those associated with intractable neurological conditions.
Another senior author on the study, Professor Jordan McCall from the Department of Anesthesiology and Center for Clinical Pharmacology at Washington University in St. Louis, said this technology has the potential to change how basic neuroscience studies are performed. “One of the biggest limitations when trying to understand how the mammalian brain works is that we have to study these functions in unnatural conditions. This technology brings us one step closer to performing important studies without direct human interaction with the study subjects.”
The ability to remotely schedule experiments moves toward automating these types of experiments. Dr. Kyle Parker, an instructor at Washington University in St. Louis and another lead author on the study added, “This experimental automation can potentially help us reduce the number of animals used in biomedical research by reducing the variability introduced by various experimenters. This is especially important given our moral imperative to seek research designs that enable this reduction.”
The researchers believe this wireless technology may open new opportunities for many applications including brain research, pharmaceuticals, and telemedicine to treat diseases in the brain and other organs remotely. This remote automation technology could become even more valuable when many labs need to shut down, such as during the height of the COVID-19 pandemic.
This work was supported by grants from the KAIST Global Singularity Research Program, the National Research Foundation of Korea, the United States National Institute of Health, and Oak Ridge Associated Universities.
-PublicationRaza Qazi, Kyle Parker, Choong Yeon Kim, Jordan McCall, Jae-Woong Jeong et al. “Scalable and modular wireless-network infrastructure for large-scale behavioral neuroscience,” Nature Biomedical Engineering, November 25 2021 (doi.org/10.1038/s41551-021-00814-w)
-ProfileProfessor Jae-Woong JeongBio-Integrated Electronics and Systems LabSchool of Electrical EngineeringKAIST
2021.11.29 View 18663 -
Plasma Jets Stabilize Water to Splash Less
< High-speed shadowgraph movie of water surface deformations induced by plasma impingement. >
A study by KAIST researchers revealed that an ionized gas jet blowing onto water, also known as a ‘plasma jet’, produces a more stable interaction with the water’s surface compared to a neutral gas jet. This finding reported in the April 1 issue of Nature will help improve the scientific understanding of plasma-liquid interactions and their practical applications in a wide range of industrial fields in which fluid control technology is used, including biomedical engineering, chemical production, and agriculture and food engineering.
Gas jets can create dimple-like depressions in liquid surfaces, and this phenomenon is familiar to anyone who has seen the cavity produced by blowing air through a straw directly above a cup of juice. As the speed of the gas jet increases, the cavity becomes unstable and starts bubbling and splashing.
“Understanding the physical properties of interactions between gases and liquids is crucial for many natural and industrial processes, such as the wind blowing over the surface of the ocean, or steelmaking methods that involve blowing oxygen over the top of molten iron,” explained Professor Wonho Choe, a physicist from KAIST and the corresponding author of the study.
However, despite its scientific and practical importance, little is known about how gas-blown liquid cavities become deformed and destabilized.
In this study, a group of KAIST physicists led by Professor Choe and the team’s collaborators from Chonbuk National University in Korea and the Jožef Stefan Institute in Slovenia investigated what happens when an ionized gas jet, also known as a ‘plasma jet’, is blown over water. A plasma jet is created by applying high voltage to a nozzle as gas flows through it, which causes the gas to be weakly ionized and acquire freely-moving charged particles.
The research team used an optical technique combined with high-speed imaging to observe the profiles of the water surface cavities created by both neutral helium gas jets and weakly ionized helium gas jets. They also developed a computational model to mathematically explain the mechanisms behind their experimental discovery.
The researchers demonstrated for the first time that an ionized gas jet has a stabilizing effect on the water’s surface. They found that certain forces exerted by the plasma jet make the water surface cavity more stable, meaning there is less bubbling and splashing compared to the cavity created by a neutral gas jet.
Specifically, the study showed that the plasma jet consists of pulsed waves of gas ionization propagating along the water’s surface so-called ‘plasma bullets’ that exert more force than a neutral gas jet, making the cavity deeper without becoming destabilized.
“This is the first time that this phenomenon has been reported, and our group considers this as a critical step forward in our understanding of how plasma jets interact with liquid surfaces. We next plan to expand this finding through more case studies that involve diverse plasma and liquid characteristics,” said Professor Choe.
This work was supported by KAIST as part of the High-Risk and High-Return Project, the National Research Foundation of Korea (NRF), and the Slovenian Research Agency (ARRS).
Image Credit: Professor Wonho Choe, KAIST
Usage Restrictions: News organizations may use or redistribute these materials, with proper attribution, as part of news coverage of this paper only.
Publication: Park, S., et al. (2021) Stabilization of liquid instabilities with ionized gas jets. Nature, Vol. No. 592, Issue No. 7852, pp. 49-53. Available online at https://doi.org/10.1038/s41586-021-03359-9
Profile:
Wonho Choe, Ph.D.
Professor
wchoe@kaist.ac.kr
https://gdpl.kaist.ac.kr/
Gas Discharge Physics Laboratory (GDPL)
Department of Nuclear and Quantum Engineering
Department of Physics
Impurity and Edge Plasma Research Center (IERC)
http://kaist.ac.kr/en/
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
(END)
2021.04.01 View 12545 -
Professor Jong Chul Ye Appointed as Distinguished Lecturer of IEEE EMBS
Professor Jong Chul Ye from the Department of Bio and Brain Engineering was appointed as a distinguished lecturer by the International Association of Electrical and Electronic Engineers (IEEE) Engineering in Medicine and Biology Society (EMBS). Professor Ye was invited to deliver a lecture on his leading research on artificial intelligence (AI) technology in medical video restoration. He will serve a term of two years beginning in 2020.
IEEE EMBS's distinguished lecturer program is designed to educate researchers around the world on the latest trends and technology in biomedical engineering. Sponsored by IEEE, its members can attend lectures on the distinguished professor's research subject.
Professor Ye said, "We are at a time where the importance of AI in medical imaging is increasing.” He added, “I am proud to be appointed as a distinguished lecturer of the IEEE EMBS in recognition of my contributions to this field.”
(END)
2020.02.27 View 14039 -
Manipulating Brain Cells by Smartphone
Researchers have developed a soft neural implant that can be wirelessly controlled using a smartphone. It is the first wireless neural device capable of indefinitely delivering multiple drugs and multiple colour lights, which neuroscientists believe can speed up efforts to uncover brain diseases such as Parkinson’s, Alzheimer’s, addiction, depression, and pain.
A team under Professor Jae-Woong Jeong from the School of Electrical Engineering at KAIST and his collaborators have invented a device that can control neural circuits using a tiny brain implant controlled by a smartphone. The device, using Lego-like replaceable drug cartridges and powerful, low-energy Bluetooth, can target specific neurons of interest using drugs and light for prolonged periods. This study was published in Nature Biomedical Engineering.
“This novel device is the fruit of advanced electronics design and powerful micro and nanoscale engineering,” explained Professor Jeong. “We are interested in further developing this technology to make a brain implant for clinical applications.”
This technology significantly overshadows the conventional methods used by neuroscientists, which usually involve rigid metal tubes and optical fibers to deliver drugs and light. Apart from limiting the subject’s movement due to bulky equipment, their relatively rigid structure causes lesions in soft brain tissue over time, therefore making them not suitable for long-term implantation. Although some efforts have been made to partly mitigate adverse tissue response by incorporating soft probes and wireless platforms, the previous solutions were limited by their inability to deliver drugs for long periods of time as well as their bulky and complex control setups.
To achieve chronic wireless drug delivery, scientists had to solve the critical challenge of the exhaustion and evaporation of drugs. To combat this, the researchers invented a neural device with a replaceable drug cartridge, which could allow neuroscientists to study the same brain circuits for several months without worrying about running out of drugs.
These ‘plug-n-play’ drug cartridges were assembled into a brain implant for mice with a soft and ultrathin probe (with the thickness of a human hair), which consisted of microfluidic channels and tiny LEDs (smaller than a grain of salt), for unlimited drug doses and light delivery.
Controlled with an elegant and simple user interface on a smartphone, neuroscientists can easily trigger any specific combination or precise sequencing of light and drug delivery in any implanted target animal without the need to be physically inside the laboratory. Using these wireless neural devices, researchers can also easily setup fully automated animal studies where the behaviour of one animal could affect other animals by triggering light and/or drug delivery.
“The wireless neural device enables chronic chemical and optical neuromodulation that has never been achieved before,” said lead author Raza Qazi, a researcher with KAIST and the University of Colorado Boulder.
This work was supported by grants from the National Research Foundation of Korea, US National Institute of Health, National Institute on Drug Abuse, and Mallinckrodt Professorship.
(A neural implant with replaceable drug cartridges and Bluetooth low-energy can target specific neurons .)
(Micro LED controlling using smartphone application)
2019.08.07 View 35257 -
Effective Drug Delivery to Heart with Tannic Acid
(Professor Haeshin Lee from the Department of Chemistry) Typical methods of drug delivery to the heart require surgical procedures involving incisions in the chest wall and bones. To efficiently treat cardiovascular and related vascular diseases without surgery, a KAIST research team developed a heart-targeting drug delivery technology using tannin acid via intravenous systemic injection. This method can be applied to the development of a variety of new protein-based drugs.
Cardiovascular-circulatory disease is currently the second leading cause of death in Korea. A typical example of this disease is myocardial infarction caused by poor oxygen and nutrient supply due to narrowed coronary arteries and poor blood flow to the heart.
Although there have been numerous research projects to develop chemotherapeutic drugs and therapeutic proteins, clinics still rely on surgical procedures. Drug delivery can be an alternative, but it is quite challenging because ceaseless dynamic cycles of the heart and massive exchanges of blood mean administered therapeutics do not stay inside the heart very long.
Professor Haeshin Lee from the Department of Chemistry and his team employed tannic acid (TA), which is known for giving bitter taste to wines. It is one of the most abundant polyphenols and can be easily found in plants, such as fruits, vegetables, cacao, and others. TA has also been used as a multifunctional coating molecule.
Using these properties of TA, the team complexed protein and peptide therapeutics with tannic acid and succeeded in targeting protein and peptide therapeutics to the heart. TA, coated on the surface of a granulated protein complex, helps maintain cardiac function because it adheres to extracellular matrices, elastin, and collagens in heart tissues allowing the protein to stay attached to the heart tissue for a longer period.
The team confirmed that these Tannic-acid-modified proteins stay in blood vessels five days longer than with protein-only injections. Additionally they found that TA-protein complexes do not show any cardiac toxicity and do not cause noticeable pathology.
The team has been continuously developing biomaterials for medical applications by testing various polyphenolic materials that feature adhesive and coating properties, including tannic acid. They have injected a mixture of TA and fibroblast growth factors (FGF) into animal models with myocardial infarctions. After four weeks, they confirmed that the infarction was reduced and the left ventricular pressure and cardiac output were almost normalized.
Professor Lee said, “Although there have been numerous drugs related to heart disease, so far there has not been efficient drug delivery to the heart so this technology will be able to reformulate existing drugs into new and more efficient drugs.”
This research, jointly led by Dr. Ki-Suk Kim from the Predictive Model Research Center, was published in Nature Biomedical Engineering on April 30 ( http://www.nature.com/articles/s41551-018-0227-9 ).
Figure 1. Schematic for the heart-targeting mechanism of TANNylated protein nanocomplexes: (1) size-dependent permeation, (2) phenolic (that is, TA), and (3) internalization by internalization by myoblasts
Figure 2. Effect of TA based protein complexes on cardiac cell transport efficiency and viral gene expression efficiency and therapeutic function in animal models with myocardial infarction
2018.09.18 View 6154 -
KAIST-KU Sign MOU on 4th Industrial Technology Development
(President Shin(second from left) poses with Khalifa University President Tod Laursen after signing an MOU in the UAE on March 25. Far left is Chairman of the NST Kwangyun Wohn and far right is the UAE Minister of Educatiion Hussain Al Hammadi.)
KAIST President Sung-Chul Shin and Khalifa University Interim President Tod Laursen signed an MOU on the Fourth Industrial Technology Development on March 25 in the UAE.
They signed the MOU during the UAE-ROK Nuclear Friendship and KAIST Alumni Night at Khalifa University co-hosted by KAIST and the Korea Atomic Energy Research Institute (KAERI). The MOU will bring new opportunities to further expand bilateral cooperation in education and training in the relevant technologies called for the era of the Fourth Industrial Revolution.
More than 100 dignitaries including Chairman of National Research Council of Science and Technology (NST) in Korea Dr. Kwangyun Wohn, President of KAERI Jaejoo Ha, the UAE Minister of Education His Excellency Hussain Al Hammadi, Minister of State for Advanced Sciences Her Excellency Sarah bint Yousef Al Amiri, and His Excellency Federal Authority for Nuclear Regulation (FANR) Director General Christopher Viktorsson attended the event. In particular, a significant number of Emirati graduates of the KUSTAR-KAIST education program and many others who completed various KAIST training programs joined the event.
The Nuclear Friendship Night was celebrating the completion of the first nuclear power plant in Barakah exported by Korea. This is the first nuclear reactor in the Middle East, which is to start operation later this year. The event also coincided with Korean President Moon Jae-In’s state visit to the UAE.
KAIST and KAERI gathered distinguished leaders from the higher education and nuclear industries at the event in response to the UAE government’s top national agenda of fostering future talents and promoting the nuclear industry in order to ensure energy security.
KAIST and Khalifa University signed an initial agreement in education and research in 2009 when the governments of Korea and the UAE signed a contract to build four nuclear power plants in Barakah. Since then, the two universities have worked together closely in the areas of nuclear engineering, bio-medical engineering, robotics, mechanical engineering, chemical engineering, and materials science. With this signing on the new MOU, the partnership between the two institutions will mark the second phase of educating high-caliber human resources in science and technology of the two countries.
The KAIST Alumni Night also brought more opportunities to appreciate the achievements that the two countries have made through collaboration in education and research, mostly represented in the field of nuclear technology between KAIST and Khalifa University. During the event, KAIST graduates also shared their experiences from the education at KAIST, followed by the welcoming speeches from the UAE Minister of Education and the UAE Minister of State for Advanced Sciences.
KAIST President Shin, in his welcoming speech at the event, said, “I look forward to more students in the UAE having the opportunity to experience the world’s top-level education and global environment that KAIST offers. The collaboration with Khalifa University and the UAE is very important for building both countries’ future growth.”
KU President Laursen said, “This MOU on research cooperation focusing on technologies for the Fourth Industrial Revolution, nuclear engineering, and other technical areas will further consolidate our partnership with KAIST and support us in developing human capital suitable to take on future challenges in the science and technology sectors. We firmly believe the talent pool of experts created by this initiative will contribute to the overall economic growth of the UAE.”
2018.03.26 View 12418 -
Scientist of March, Professor Hee-Seung Lee
(Professor Hee-Seung Lee)
Professor Hee-Seung Lee from the Department of Chemistry at KAIST received the ‘Science and Technology Award of the Month’ awarded by the Ministry of ICT and Science, and the National Research Foundation of Korea for March 2018.
Professor Lee has been recognized for successfully producing peptide-based molecular machines, which used to be made of metals.
The methodology can be translated into magnetotactic behavior at the macroscopic scale, which is reminiscent of magnetosomes in magnetotactic bacteria.
The team employed foldectures, self-assembled molecular architectures of β-peptide foldamers, to develop the peptide-based molecular machines that uniformly align with respect to an applied static magnetic field.
Professor Lee said, “Molecular machines are widely used in the field of medical engineering or material science; however, there were limitations for developing the machines using magnetic fields. By developing peptide-based molecular machines, we were able to develop body-friendly molecular machines.”
Every month, the Ministry of ICT and Science and the National Research Foundation of Korea award a cash prize worth 10,000,000 KRW to a scientist who has contributed to science and technology with outstanding research and development performance.
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Professor Lee Co-chairs the Global Future Councils on Biotechnology of the WEF
The World Economic Forum (WEF) established a new global network of the world’s leading experts, “The Annual Meeting of the Global Future Councils,” to explore innovative solutions for the most pressing global challenges. The Councils’ first meeting took place on November 13-14, 2016, in Dubai, the United Arab Emirates (UAE). Some 25 nations joined as member states. The Councils have 35 committees.
Over 700 global leaders in business, government, civil society and academia gathered at the inaugural meeting to “develop ideas and strategies to prepare the world for the Fourth Industrial Revolution, with topics including smart cities, robotics, and the future of mobility,” according to a statement issued by the WEF.
Distinguished Professor Sang Yup Lee of Chemical and Biomolecular Engineering at KAIST was appointed to co-chair one of the Councils' committees, The Annual Meeting of the Global Future Councils on Biotechnology, for two years. The other chairperson is Dr. Feng Zhang, a professor of Biomedical Engineering at the Massachusetts Institute of Technology (MIT), who played a critical role in the development of optogenetics and CRISPR technologies.
The Biotechnology Committee consists of 24 globally recognized professionals in life sciences, law, ethics and policy including Thomas Connelly, the executive director of the American Chemical Society, Tina Fano, the executive vice president of Novozymes, and Mostafa Ronaghi, the chief technology officer of Illumina.
Professor Lee also serves as a committee member of The Annual Meeting of the Global Future Councils on the Fourth Industrial Revolution.
“Life sciences and engineering will receive more attention as a key element of the Fourth Industrial Revolution that the global society as a whole has been experiencing now. Together with thought leaders gathered worldwide, I will join the international community’s concerted efforts to address issues of importance that impact greatly on the future of humanity,” Professor Lee said.
In addition, Professor Lee received the James E. Bailey Award 2016 from The Society for Biological Engineering on November 15, 2016. He is the first Asian researcher to be recognized for his contributions to the field of biotechnology.
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KAIST and the University of Minnesota-Twin Cities Partner for Research and Education Collaboration
President Steve Kang of KAIST and President Eric W. Kaler of the University of Minnesota-Twin Cities (United States) signed a memorandum of understanding to create exchange programs for students and faculty and to conduct joint research in the field of health and food. The following is an excerpt from President Kaler’s blog (https://storify.com/UMNstory/globalumn-hksk#edaadf) on his visit of KAIST on November 18, 2015:
A visit to the Korea Advanced Institute of Science and Technology
About 90 miles from Seoul—and more than that two-and-a-half-hours of a bus ride through the rugged early-morning traffic of South Korea’s capital city—sits Daejeon, Korea’s sixth largest city and home to KAIST, the Korea Advanced Institute of Science and Technology. Today, President Kaler and the small University of Minnesota delegation accompanying him visited what’s considered Korea’s MIT, a place focused on research and known to push the limits toward the future.
Fingernail heart monitors? Wireless anesthetic-monitoring devices?
KAIST is working on them.
The overlap of interests—from biomedical engineering to nanotechnology to robotics—between KAIST (pronounced “Kyst”) and the U are remarkable. Smartphone apps to monitor human health and GPS-driven robots to serve military interests or deliver packages were among the developing inventions that KAIST scientists showed to Kaler.
And even the personal relationships seem to illustrate the cliché of a small world and the natural affinity of Minnesota and KAIST.
KAIST’s President Sang Mo Kang was once the head of the University of Illinois’ department of electrical and computer engineering, and he and Kaler—a renowned chemical engineer before becoming the U’s president—hit it off … despite disagreeing about the potential outcome of Saturday’s Illinois-Gophers football game.
Accompanying Kaler on the day’s journey, meetings, and signing of a Memorandum of Understanding between the two schools to advance collaborations was U Associate Professor Sang Hyun Oh. Oh happens to be a physics graduate of this very KAIST and is now a rising star in Minnesota’s Department of Electrical and Computer Engineering.
The two sides agreed to focus on matching scholars on their respective campuses to discuss the sorts of research the two institutions can partner on. The idea of “Grand Challenges,” at the core of the U’s Twin Cities campus Strategic Plan, has fascinated Korean higher education leaders during Kaler’s weeklong visit, and KAIST’s leadership was interested in the health and food research, two U strengths.
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2015.12.04 View 10378