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KAIST's Mathematician Reveals the Mechanism for Sustaining Biological Rhythms
Our bodies have a variety of biological clocks that follow rhythms or oscillations with periods ranging from seconds to days. For example, our hearts beat every second, and cells divide periodically. The circadian clock located in the hypothalamus generates twenty-four hour rhythms, timing our sleep and hormone release. How do these biological clocks or circuits generate and sustain the stable rhythms that are essential to life?
Jae Kyoung Kim, who is an assistant professor in the Department of Mathematical Sciences at KAIST, has predicted how these biological circuits generate rhythms and control their robustness, utilizing mathematical modeling based on differential equations and stochastic parameter sampling. Based on his prediction, using synthetic biology, a research team headed by Matthew Bennett of Rice University constructed a novel biological circuit that spans two genetically engineered strains of bacteria, one serves as an activator and the other as a repressor to regulate gene expression across multiple cell types, and found that the circuit generates surprisingly robust rhythms under various conditions.
The results of the research conducted in collaboration with KAIST (Korea Institute of Science and Technology), Rice University, and the University of Houston were published in Science (August 28, 2015 issue). The title of the paper is "Emergent Genetic Oscillations in a Synthetic Microbial Consortium" .
The top-down research approach, which focuses on identifying the components of biological circuits, limits our understanding of the mechanisms in which the circuits generate rhythms. Synthetic biology, a rapidly growing field at the interface of biosciences and engineering, however, uses a bottom-up approach.
Synthetic biologists can create complex circuits out of simpler components, and some of these new genetic circuits are capable of fluctuation to regulate gene production. In the same way that electrical engineers understand how an electrical circuit works as they construct batteries, resistors, and wires, synthetic biologists can understand better about biological circuits if they put them together using genes and proteins. However, due to the complexity of biological systems, both experiments and mathematical modeling need to be applied hand in hand to design these biological circuits and understand their function.
In this research, an interdisciplinary approach proved that a synthetic intercellular singling circuit generates robust rhythms to create a cooperative microbial system. Specifically, Kim's mathematical analysis suggested, and experiments confirmed, that the presence of negative feedback loops in addition to a core transcriptional negative feedback loop can explain the robustness of rhythms in this system. This result provides important clues about the fundamental mechanism of robust rhythm generation in biological systems.
Furthermore, rather than constructing the entire circuit inside a single bacterial strain, the circuit was split among two strains of Escherichia coli bacterium. When the strains were grown together, the bacteria exchanged information, completing the circuit. Thus, this research also shows how, by regulating individual cells within the system, complex biological systems can be controlled, which in turn influences each other (e.g., the gut microbiome in humans).
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Ye Chen, a graduate student in Bennett's laboratory at Rice University, and Jae Kyoung Kim, an assistant professor at KAIST and a former postdoctoral fellow at Ohio State University, are the lead authors of the paper. The co-authors are Rice graduate student Andrew Hirning and Krešimir Josic?, a professor of mathematics at the University of Houston. Bennett is the Assistant Professor of the Biochemistry and Cell Biology Department at Rice University.
About the researcher: While Jae Kyoung Kim is a mathematician, he has also solved various biological puzzles in collaboration with various experimental laboratories of Matthew Bennett at Rice University, David Virshup at Duke and the National University of Singapore, Carla Finkielstein at Virginia Polytechnic Institute and State University, Choo-Gon Lee at the Florida State University, Seung-Hee Yoo at the Medical School of the University of Texas, Toru Takumi at RIKEN Brain Science Institute, and Travis Wager at Pfizer Inc. He has used non-linear dynamics and stochastic analysis to understand the function of biochemical networks in biological systems. In particular, he is interested in mechanisms generating and regulating biological rhythms.
Picture 1: This schematic image is the design of a biological circuit between two strains of bacteria and the part of differential equations used to understand the function of the biological circuit.
Picture 2: The core transcriptional negative feedback loop and additional negative feedback loop in the biological circuit (picture 1) generate robust rhythms. The snapshots correspond the red dots in the time series graph.
2015.08.31 View 9054 -
KAIST and the Czech Academy of Sciences Agree to Cooperate
KAIST and the Czech Academy of Sciences (CAS) signed a memorandum of understanding in the office of KAIST’s president on August 11, 2015. Ten people from the two institutions, including President Steve Kang of KAIST and Chairman Jiří Drahoš of CAS participated in the signing ceremony.
Under the agreement, the two institutions will cooperate on establishing joint research programs, sharing up-to-date research outcomes, and medium-and long-term exchange of researchers.
Having more than 50 public laboratories all over the Czech Republic, the Czech Academy of Sciences is the largest research institution in the country. Its research body along with the staff has eight thousand members. The institution focuses on mathematics, physics, biotechnology, and social sciences while running its own Ph.D. program.
President Kang said, “I hope this signing will expand our cooperation with universities and research institutions in Eastern Europe.”
2015.08.18 View 4802 -
President Steve Kang of KAIST Receives the Outstanding Contribution Award from the Korean-American Scientists and Engineers Association
The Korean-American Scientists and Engineers Association (KSEA), a non-profit Korean professional organization based in the United States with over 6,000 registered members, bestowed upon President Steve Kang of KAIST the 2015 Outstanding Contribution Award.
The award is presented to a person who has made significant contributions to the development of KSEA.
The award ceremony took place during the 2015 US-Korea Conference on Science, Technology, and Entrepreneurship (UKC), which was held on July 30, 2015, at the Hyatt Regency Hotel in Atlanta, Georgia.
The UKC is the flagship conference of KSEA, which takes place every year, and covers science, engineering, technology, industry, entrepreneurship, and leadership. It attracts more than 1,200 participants from the US and Korea. The UKC 2015 was held on July 29-August 1, 2015.
President Kang has participated in UKC conferences over the past few years as a plenary speaker, addressing major issues in science and technology for both nations, and provided generous support for the activities of UKC and KSEA. He also promoted discussions and exchanges of professional knowledge in his field, microelectronics, by organizing fora and symposia.
He addressed the UKC 2015 as a plenary speaker with a speech entitled “Pursuing Excellence with a Servant’s Heart.” President Kang said that good leadership should bring out synergistic contributions from all constituents and achieve excellence under all circumstances. He mentioned one example of good leadership, known as humble leadership, and explained how such leadership played an important role in the development of scientific breakthroughs, such as the world’s premier high-end microprocessor chip sets first produced by his team under extremely high pressure.
2015.08.05 View 8114 -
KAIST Operates a Summer School with Imperial College London
KAIST and Imperial College London jointly hosted a summer school on the KAIST campus on July 14-17, 2015. Twenty-five students from both universities, 11 from KAIST and 14 from Imperial College, participated in the summer program.
KAIST and Imperial College agreed to hold academic and research exchange programs in 2013; this year’s summer school represented the first effort.
Participants were divided into a few cohorts of four or five students. They conducted a series of activities to implement joint research projects involving team building, networking, joint study, discussions, and presentations.
Among the projects the summer school ran, Professor Hoi-Jun Yoo of the Electrical Engineering Department at KAIST was invited to teach students about the mobile healthcare system, Dr. M, that he had developed.
Sung-Hyon Myaeng, Associate Vice President of the International Affairs Office, KAIST, said, “This summer school is yet another example of KAIST’s ongoing efforts to make the campus more global and to interact actively with members of the international community.”
2015.07.29 View 8598 -
KAIST Undergraduates Organize the Largest Interdisciplinary Conference in Asia
The largest interdisciplinary conference in Asia hosted by KAIST undergraduates for students around the world will be held in KAIST. The organizing committee of International Conference for the Integration of Science, Technology and Society (ICISTS) will hold the ICISTS-KAIST 2015 in KAIST and Hotel ICC from August 3-7, 2015, with around 300 Korean and international participants.
ICISTS-KAIST was established in 2005 to provide an annual platform for students to discuss the integration and the convergence of science, technology and society, regardless of their academic background.
This year’s theme is "Shaping the Future" and the topics for the conference are robotics, medicine, and science communication.
The keynote speakers are Vitalic Buterin, the winner of the World Technology Award in 2014 for the co-creation and invention of Ethereum and Alan Irwin, a well-known scholar of science, technology and society as well as the Dean of Research at the Copenhagen Business School in Denmark.
Other notable speakers include Adam Marcus, a professor of Hematology and Medical Oncology, Emory University School of Medicine; Stefan Lorenz Sorgner, the Director and co-founder of Beyond Humanism Network; Hideto Nakajima, a professor in the Department of History, Philosophy and Social Studies of Science and Technology at Tokyo Institute of Technology; Wendell Wallach, a lecturer at the Yale University Interdisciplinary Center for Bioethics; Jinil Lee, a professor in the Division of Biological Science and Technology at Yonsei University; and Sangwook Kim, an editor of APCTP web journal Crossroads and a professor in the Department of Physics Education, Pusan National University.
Last year, more than 300 students from 50 different countries attended the ICISTS-KAIST 2014 as delegates to exchange their thoughts and ideas on science, technology, and society.
To register for the event, please visit www.icists.org.
2015.07.14 View 8712 -
Dong-Young Lee, a Doctoral Candidate, Receives the Best Paper Award
Dong-Young Lee, a Ph.D. candidate in the Mechanical Engineering Department, KAIST, received the Best Paper Award at the 18th International Conference on Composite Structures (ICCS). The event was held in Lisbon, Portugal, on June 15-18, 2015. Mr. Lee’s adviser is Professor Dai-Gil Lee of the same department.
The ICCS is held every other year, and is one of the largest and long-established conferences on composite materials and structures in the world. At this year’s conference, a total of 680 papers were presented, among which, two papers were chosen for the Best Paper Award, including Mr. Lee’s.
The paper, entitled “Gasket-integrated Carbon and Silicon Elastomer Composite Bipolar Plate for High-temperature PEMFC,” will be published in the September issue of Composite Structures which is one of the top journals in mechanical engineering as judged by the Google Scholar Metrics rankings.
Mr. Lee dropped the conventional method of PEMFC (Proton Exchange Membrane Fuel Cells) assembly and instead developed a gasket-integrated carbon and silicone elastomer composite bipolar plate. This technology significantly increased the energy efficiency of fuel cells and their productivity.
Mr. Lee said, “I would like to thank the many people who supported me, especially my Ph.D. adviser, Professor Dai-Gil Lee. Without their encouragement, I would have not won this award. I hope my research will contribute to solving energy problems in the future.”
In addition, Professor Joon-Woo Im from Chonbuk National University, Senior Researcher Il-Bum Choi from the Agency for Defense Development, and a fellow doctoral candidate Soo-Hyun Nam from KAIST participated in this research project.
2015.07.09 View 10336 -
Science and Technology Policy Professor Chihyung Jeon Awarded Rachel Carson Fellowship
KAIST Graduate School of Science and Technology Policy Professor Chihyung Jeon has been awarded the Rachel Carson Fellowship 2015-2016.
Rachel Carson Center for Environment and Society is a research center for environmental humanities and social sciences, supported by the German Federal Ministry of Education and Research. It was founded by Ludwig-Maximilians-Universität, Munich, Germany and the Deutsches Museum as a joint initiative in 2009.
Rachel Carson Center supports researches in humanities and social sciences on the interactions between the environment and the society, following the footsteps of Rachel Cason, who raised awareness on the chemical environmental damage and started global environmental movement through her published book “Silent Spring” in 1962.
The center is awarding Rachel Carson Fellowships to established researchers to fund their writing and promote exchange of research. This year, 31 fellowships were awarded.
Professor Jeon will conduct research on "A Dredged Nation: The Four Rivers Restoration Project and the Envirotechnical Transformation of South Korea" and will also hold an additional post of International Curatorial Fellow at the Deutsches Museum.
2015.06.11 View 10582 -
KAIST to Kick-Start the Exchange of Young Researchers with Northern European Universities
KAIST promotes research exchange and cooperation with three universities in Northern Europe.
KAIST has signed a letter of intent (LOI) for the mutual exchange of young researchers and cooperation to collaborate with KTH Royal Institute of Technology and Lund University, both based in Sweden on June 2, 2015, and with Aalto University in Finland on June 4, 2015.
This LOI was the result of the cooperative projects of Korea-Sweden and Korea-Finland Joint Committees on Science and Technology supervised by the Ministry of Science, ICT and Future Planning of Korea.
As agreed in the LOI, KAIST will conduct joint research projects with the three universities by providing students and researchers with opportunities to visit each other through internship programs and workshops and by sharing information on education and research.
Sung-Hyon Mayeng, the Associate Vice President of the International Relations Office at KAIST, said, “It’s an encouraging sign that universities and governments recognize the importance of increasing exchanges among academic and research communities. Expecting more vibrant relationships to be formed between KAIST and the three northern European universities in coming years, I hope that today’s agreement becomes a good basis to spur technological innovations that will not only benefit the regions but also the world.”
Established in 1827, the KTH Royal Institute of Technology is the largest and oldest technical university in Sweden, accounting for one-third of the nation’s technical research and engineering education capacity at university level. The university offers education and research programs from natural sciences to all branches of engineering including architecture, industrial management, and urban planning. According to the QS World University Rankings in 2014, KTH Royal Institute of Technology ranked 27th in engineering and 1st in Northern Europe.
Lund University, Sweden, is one of the oldest and most prestigious universities in northern Europe, consistently ranking among the world’s top 100 universities. In particular, its biological sciences and engineering have shown great strength, placing within the top 60 universities by the Times Higher Education (THE) World University Rankings. The university also receives the largest amount of research funding from the Swedish government.
Aalto University in Finland was created as a merger of three leading Finnish universities: the Helsinki University of Technology (established 1849), the Helsinki School of Economics (established 1904), and the University of Art and Design Helsinki (established 1871). The university nurtures the close collaborations across science, business, and arts to foster multi-disciplinary education and research.
2015.06.04 View 9135 -
World Renowned Wireless Technology Experts Gathered in KAIST
KAIST hosted the 2015 IEEE WoW from June 5 to 6, 2015
Wireless power transfer technologies, such as wireless electric vehicles, trains and batteries, are increasingly in use. A conference, The 2015 IEEE WoW (Workshop on Wireless Power), was held in KI Building for two days starting June 5, 2015 to exchange ideas on the new trends and issues of the world wireless power technology.
The wireless power conference hosted by Institute of Electrical and Electronics Engineers (IEEE), IEEE WoW, was sponsored by its societies, PELS, IAS, IES, VTS, MAG, and PES.
This year’s conference took place in Korea for the first time and was titled “IEEE PELS Workshop on Emerging Technologies: Wireless Power.” The event was attended by around 200 experts in wireless power from 15 countries to discuss the international standards and current trends.
Keynote speakers were President Don Tan of IEEE; Professor Grant Covic of the University of Auckland; Andrew Daga, the CEO at Momentum Dynamics Corporation; Professor Ron Hui of the City University of Hong Kong; and Jung Goo Cho, the CEO of Green Power Technologies.
The forum included plenary speaking sessions on “The Futures of EV and Power Electronics,” “Development of IPT at the University of Auckland,” “Interoperable Solution for Wireless EV Charging,” “Development of IPT for Factory Automation,” “Commercialization of High Power WPT,” and “WPT: From Directional Power to Omni-directional Power.”
Notably, KAIST Professor Dong-Ho Cho, responsible for KAIST’s On-Line Electric Vehicle (OLEV) development, spoke on “The Development of Shaped Magnetic Field Systems for EVs and Trains” to introduce the KAIST OLEV bus and OLEV trains developed in cooperation with Korea Railroad Research Institute.
The Dialog Sessions on “The Futures of Wireless Electric Vehicles” were led by John M. Miller of JNJ Miller and “Road Charged EV and WPT Regulation and Standard for EV in Japan” by Yoichi Hori of University of Tokyo.
The General Chair of this year’s IEEE WoW, KAIST Professor Chun T. Rim said, “This forum serves a great assistance to the industry using wireless power technology in areas such as smartphones, home appliances, Internet of Things, and wearable devices.”
2015.05.29 View 10035 -
KAIST International Food Festival
The KAIST International Students Association (KISA) hosted the 2015 International Food Festival in front of Creative Learning Building, KAIST, on May 22, 2015.
This was the 11th International Food Festival for KAIST where international students introduced food from their home countries to strengthen cultural exchanges with Korean students. This year’s festival was the biggest international festival in Daejeon in which around 500 students and staff from KAIST, Chungnam National University (CNU), the University of Science & Technology (UST), and the public participated.
KAIST’s President Steve Kang opened the festival with a welcoming speech, followed by congratulatory speeches by CNU President Sang-Chul Jung and UST President Un-Woo Lee.
The first section of the event was the food festival where around 40 kinds of food from ten countries including Kenya, Kazakhstan, India, and Turkey were presented. Students from each country offered cooking demonstrations in booths, and participants purchased the food.
Cheryl Wanderi, a Kenyan student who recently received a Master’s degree from KAIST’s Department of Bio and Brain Engineering last February said, “I am delighted to introduce Mandazi, a Kenyan donut, to not only Korean students but also other international students.”
The second half of the event consisted of cultural performances from different countries. There were eight teams performing including an Indonesian traditional Saman dance team, a Kazakh group that performed on traditional instruments, and an Azerbaijani K-POP dance team.
Sung-Hyon Myaeng, the Associate Vice President of KAIST’s International Office, said, “Despite their busy lives, students from three different universities planned this event to get to know each other. I hope international students and Korean students can come together and enjoy the festival.”
Edrick Kwek, the President of KISA, said, “This food festival is an event showing the cultural diversity of KAIST in the most splendid way.”
2015.05.27 View 10424 -
KAIST Connects CNU with Pedestrian Walkway
KAIST and Chungnam National University (CNU) built a pedestrian walkway ("pedway") that physically brings them closer than ever. Opened on April 13, 2015, the KAIST-CNU Pedway now offers members of the two universities a quick and scenic road to walk or bike for their campus visit.
The 180-meter-strip, with a width of four meters, starts from KAIST’s student dormitories, Narae and Mir Halls, and arrives at the backyard of the College of Agriculture and Life Sciences building at CNU. For security and safety precaution, emergency alarms, CCTVs and security lights are installed along the path.
A commemorative event celebrating the opening of the pedway was held on April 15, 2015 at the KAIST campus. Along with senior administrators of the two universities, In-Sik Kim, Chairman of Daejeon City Assembly, Choon-Hee Baek, Deputy Mayor for Political Affairs of Daejeon, President Steve Kang of KAIST, and President Sang-Chul Jung of CNU will attend the event.
CNU is located just a twenty-minute walk from KAIST, but the two universities have had little interaction. To promote more collaboration and exchange, KAIST and CNU signed a memorandum of understanding on the cooperation of education, research, and medicine in June 2014.
With the KAIST-CNU Pedway as the stepping stone, the two universities will strengthen their cooperation in academic information exchange allowing access to their libraries and establishing the Graduate School of Integrated Medical Science in Sejong.
President Kang said, “Universities should not be isolated islands from the local community, but should act as bridges between different districts.” He continued, “I hope this pedway can be the starting point.”
President Jung said, “I hope this road can remove the wall between KAIST and Chungnam National University, in terms of knowledge, information, and people. I further hope that it will become the symbol and token of unity of the two universities.”
2015.04.13 View 7787 -
KAIST and Hancom Sign for Development of Mobile Healthcare
KAIST signed a memorandum of understanding with Hancom, Inc., an office suite developer in Korea, to foster mobile healthcare software programs. President Steve Kang and Chairman Sang-Chul Kim of Hancom held a signing ceremony on March 13, 2015 at the KAIST campus.
Based on the agreement, KAIST and Hancom will exchange research personnel to build Dr. M, a smart healthcare platform developed by the university, collaborate in research and development, and cooperate in the transfer of research developments from the university to the software industry including Hancom.
KAIST and Hancom also signed a memorandum of understanding on the development of software in April 2014. The Hancom-KAIST Research Center opened on campus last October.
2015.03.20 View 9844