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Professor Jae Kyoung Kim Receives the 2017 HSFP Award
The Human Frontier Science Program (HSFP), one of the most competitive research grants in life sciences, has funded researchers worldwide across and beyond the field since 1990. Each year, the program selects a handful of recipients who push the envelope of basic research in biology to bring breakthroughs from novel approaches. Among its 7,000 recipients thus far, 26 scientists have received the Nobel Prize. For that reason, HSFP grants are often referred to as “Nobel Prize Grants.”
Professor Jae Kyoung Kim of the Mathematical Sciences Department at KAIST and his international collaborators, Professor Robert Havekes from the University of Groningen, the Netherlands, Professor Sara Aton from the University of Michigan in Ann Arbor, the United States, and Professor Matias Zurbriggen from the University of Düsseldorf, Germany, won the Young Investigator Grants of the 2017 HSFP.
The 30 winning teams of the 2017 competition (in 9 Young Investigator Grants and 21 Program Grants) went through a rigorous year-long review process from a total of 1,073 applications submitted from more than 60 countries around the world. Each winning team will receive financial support averaging 110,000-125,000 USD per year for three years.
Although Professor Kim was trained as a mathematician, he has extended his research focus into biological sciences and attempted to solve some of the most difficult problems in biology by employing mathematical theories and applications including nonlinear dynamics, stochastic process, singular perturbation, and parameter estimation.
The project that won the Young Investigator Grants was a study on how a molecular circadian clock may affect sleep-regulated neurophysiology in mammals. Physiological and metabolic processes such as sleep, blood pressure, and hormone secretion exhibit circadian rhythms in mammals. Professor Kim used mathematical modeling and analysis to explain that the mammalian circadian clock is a hierarchical system, in which the master clock in the superchiasmatic nucleus, a tiny region in the brain that controls circadian rhythms, functions as a pacemaker and synchronizer of peripheral clocks to generate coherent systematic rhythms throughout the body.
Professor Kim said, “The mechanisms of our neuronal and hormonal activities regulating many of our bodily functions over a 24-hour cycle are not yet fully known. We go to sleep every night, but do not really know how it affects our brain functions. I hope my experience in mathematics, along with insights from biologists, can find meaningful answers to some of today’s puzzling problems in biological sciences, for example, revealing the complexities of our brains and showing how they work.”
“In the meantime, I hope collaborations between the fields of mathematics and biology, as yet a rare phenomenon in the Korean scientific community, will become more popular in the near future.”
Professor Kim received his doctoral degree in Applied and Interdisciplinary Mathematics in 2013 from the University of Michigan and joined KAIST in 2015. He has published numerous articles in reputable science journals such as Science, Molecular Cell, Proceedings of the National Academy of Sciences, and Nature Communications.
Both the Program Grants and Young Investigator Grants support international teams with members from at least two countries for innovative and creative research. This year, the Program Grants were awarded to research topics ranging from the evolution of counting and the role of extracellular vesicles in breast cancer bone metastasis to the examination of obesity from a mechanobiological point of view.
The Young Investigator Grants are limited to teams that established their independent research within the last five years and received their doctoral degrees within the last decade. Besides Professor Kim’s study, such topics as the use of infrasound for navigation by seabirds and protein formation in photochemistry and photophysics were awarded in 2017.
Full lists of the 2017 HFSP winners are available at: http://www.hfsp.org/awardees/newly-awarded.
About the Human Frontier Science Program (HFSP):
The HFSP is a research funding program implemented by the International Human Frontier Science Program (HFSPO) based in Strasbourg, France. It promotes intercontinental collaboration and training in cutting-edge, interdisciplinary research specializing in life sciences. Founded in 1989, the HFSPO consists of the European Union and 14 other countries including the G7 nations and South Korea.
2017.03.21 View 13041 -
A KAIST Alumnus Receives the Marie Sklodowska-Curie Individual Fellowships
Dr. Je-Kyung Ryu, a graduate of the Physics Department at KAIST in 2014, received the 2017 Marie Sklodowska-Curie Individual Fellowship.
Established in 1996, the Marie Sklodowska-Curie Individual Fellowships support young scientists in or outside Europe to help them grow as independent researchers. The recipients are recognized to have the highest potential to make a difference in science and technology and work on research and innovation.
Dr. Ryu is currently working as a postdoctoral researcher at the Cees Dekker Lab in the Department of Bionanoscience at the Kavli Institute of Nanoscience at Delft University of Technology (TU Delft), Netherlands.
He was among six international researchers at TU Delft who were awarded this research grant.
The grant of 177,000 euros will be offered for two years from March 2017 to February 2019 to cover his salary and research expenses.
For a news article published by TU Delft on the award, please click below:
QN and BN Successfully Attract Young Scientific Talent
February 1, 2017
2017.02.22 View 7800 -
Dr. Sung-Chul Shin Selected 16th President of KAIST
(President Sung-Chul Shin)
The KAIST Board of Trustees elected Professor Sung-Chul Shin of the Department of Physics the 16th president of KAIST on February 21. Professor Shin succeeds President Sung-Mo Kang whose four-year term will end on February 23. He is the first KAIST alumnus to serve as its president.
The Board of Trustees announced, “We believe that Professor Shin’s scientific achievement, outstanding leadership, and clear vision will serve KAIST faculty, students, and staff very well. He will be the best person to help KAIST leap forward in the four years ahead.”
The newly-elected president said, “I am humbled and honored to have been elected to lead such a prestigious institute of Korea. Aiming to be one of the top ten global universities, KAIST will continue to innovate its systems.” Previously, Dr. Shin led the Daegu Gyeongbuk Institute of Science and Technology (DGIST) for six years as president since 2011.
Professor Shin joined the KAIST faculty in 1989. He graduated from Seoul National University and then earned his MS degree in condensed matter physics at KAIST in 1977. After earning his Ph.D. in material physics at Northwestern University in 1984, he worked at Eastman Kodak Research Labs as a senior research scientist for five years.
Before heading to DGIST, President Shin held key administrative positions at KAIST from the early 1990s including dean of planning, dean of the international office, and vice-dean of student affairs. During President Robert Laughlin’s tenure, the first foreign president at KAIST, he served as vice-president for two years from 2004. He also served on the Presidential Advisory Council on Science and Technology of the Korean government as vice chairperson from 2015 to 2016.
A renowned scholar in the field of nanoscience, President Shin’s research focuses on the artificial synthesis and characterization of nonmagnetic materials, magnetic anisotropy, and magneto-optical phenomena. He leads the Laboratory for Nanospinics of Spintronic Materials at KAIST and has published in 290 journals while holding 37 patents.
A fellow in the American Physical Society (APS) since 2008, he was the president of the Korean Physical Society from 2011 to 2012. He has been on the editorial board of J. Magnetism and Magnetic Materials from 2009 and was the first Korean recipient of the Asian Union of Magnetics Societies (AUMS) Award, which recognizes outstanding scientists in the field of magnetics.
President Shin envisions making KAIST’s research and education more competitive through continuing innovation. His innovation efforts will extend to the five key areas of education, research, technology commercialization, globalization, and future planning.
Among his priorities, he emphasizes multidisciplinary studies and leadership training for students. He plans to focus on undeclared major courses for undergraduates to help them expand their experience and exposure to diverse disciplines. This approach will help create well-rounded engineers, scientists, and entrepreneurs by enabling them to develop skills while leveraging a strong connection to the arts, humanities, and social sciences.
To better respond to Industry 4.0, which calls for convergence studies and collaborative work, he proposed establishing a ‘Convergence Innovation System’ by strategically selecting 10 flagship convergence research groups. In order to accelerate the technology commercialization and ecosystem of start-ups, he will strengthen entrepreneurship education, making it a prerequisite requirement for students. President Shin said he will spare no effort to incubate and spin-off ventures in which KAIST technology is being transferred. For globalization efforts, he plans to increase the ratio of foreign faculty from 9 percent to 15 percent, while doubling the current foreign student enrollment ratio of 5 percent. For future strategic innovation, he will implement a long-term innovation strategic plan dubbed ‘Vision 2031.’
2017.02.22 View 14177 -
KAISTian of the Year 2016: Professor Hee-Sung Park
Professor Hee-Sung Park of the Department of Chemistry has been named the KAISTian of 2016. President Sung-Mo Kang awarded him at the New Year ceremony on January 2, 2017.
The KAISTian of the Year recognizes the most outstanding professor whose research and scholarship made significant achievements for the year. The Selection Committee announced that Professor Park was chosen as the 16th awardee in recognition of his developing new methods to incorporate unnatural amino acids into proteins.
Earning his Ph.D. in chemical engineering at KAIST in 2000, Professor Park has been a professor at KAIST since 2009. His research focuses on the production of synthetic proteins and the generation of diverse protein functions as well as the designing and engineering of new translation machinery for genetic code expansion, and the application of synthetic biology techniques for basic cell biology and applied medical science.
He developed a tool to engineer designer proteins via diverse chemical modifications, providing a novel platform for investigating numerous diseases such as cancer and dementia. Post-translational modifications (PTMs) are constantly taking place during or after protein biosynthesis. PTMs play a vital role in expanding protein functional diversity and, as a result, critically affect numerous biological processes. Abnormal PTMs have been known to trigger various diseases including cancer and dementia. Therefore, this technology, that enables proteins to reproduce with specific modifications at selected residues, will significantly help establish experimental strategies to investigate fundamental biological mechanisms including the development of targeted cancer therapies.
Professor Park’s research results appeared in the September 28, 2016 edition of Science. For more on Professor Park's research, please visit:
http://kaistcompass.kaist.ac.kr/?issues=fall-2016&magazine=a-chemical-biology-route-to-site-specific-authentic-protein-modifications
http://science.sciencemag.org/content/early/2016/09/28/science.aah4428
http://www.kaist.ac.kr/html/en/news/podcast.html (Podcast: Season 6 Episode 7: When good proteins go bad )
2017.01.10 View 9405 -
Nobel Laureate Dr. John Michael Kosterlitz Speaks at KAIST
KAIST’s Department of Physics will invite one of three co-recipients of the Nobel Prize in Physics 2016, Professor John Michael Kosterlitz of Brown University, on January 9, 2017, to speak about the exotic states of matter, which is entitled “Topological Defects and Phase Transitions.”
Professor Kosterlitz shares the Nobel award with two other researchers, David Thouless and Duncan Haldane. He is considered one of the pioneers in the field of topological phases. In the early 1970s, along with Thouless, he demonstrated that superconductivity could occur at low temperatures and explained the mechanism behind, phase transition, that makes superconductivity disappear at higher temperatures.
Over the last decade, topological materials and their applications have been widely studied with the hope of using them in new generations of electronics and superconductors, or in future quantum computers. Details of the lecture follow below:
Distinguished Lecture Series by KAIST’s Physics Department
· Speaker: Professor John Michael Kosterlitz of the Physics Department,
Brown University
· Topic: “Topological Defects and Phase Transitions”
· Date: January 9, 2017, 4:00 PM
· Place: Lecture Hall (#1501), College of Natural Sciences (E6-2)
2017.01.06 View 9405 -
Key Interaction between the Circadian Clock and Cancer Identified
Professor Jae Kyoung Kim and his research team from the Department of Mathematical Sciences at KAIST found that the circadian clock drives changes in circadian rhythms of p53 which functions as a tumor suppressor. Using a differential equation, he applied a model-driven mathematical approach to learn the mechanism and role of p53.
Kim’s mathematical modeling has been validated by experimental studies conducted by a research team at Virginia Polytechnic Institute and State University (Virginia Tech) in the United State, which is led by Professor Carla Finkielstein. As a result, the researchers revealed that there is an important link existed between the circadian clock and cancer.
The findings of this research were published online in Proceedings of the National Academy of Sciences of the United States of the America (PNAS) on November 9, 2016.
The circadian clock in our brain controls behavioral and physiological processes within a period of 24 hours, including making us fall asleep at a certain time by triggering the release of the sleep hormone melatonin in our brain, for example, around 9 pm. The clock is also involved in various physiological processes such as cell division, movement, and development.
Disruptions caused by the mismatch of the circadian clock and real time due to chronic late night work, shiftwork, and other similar issues may lead to various diseases such as diabetes, cancer, and heart disease.
In 2014, when Kim met with Finkielstein, her research team succeeded in observing the changes of p53 over a period of 24 hours, but could not understand how the circadian clock controls the 24-hour rhythm of p53. It was difficult to determine p53’s mechanism since its cell regulation system is far more complex than other cells
To solve the problem, Kim set up a computer simulation using mathematical modeling and ran millions of simulations. Instead of the traditional method based on trial and error experiments, mathematical modeling allowed to save a great deal of time, cost, and manpower.
During this process, Kim proved that the biorhythm of p53 and Period2, an important protein in the circadian clock, are closely related. Cells usually consist of a cell nucleus and cytoplasm. While p53 exists in both nucleus and cytoplasm, it becomes more stable and its degradation slows down when it is in the nucleus.
Kim predicted that the Period2 protein, which plays a key role in the functioning of the circadian clock, could influence the nucleus entry of the p53 protein.
Kim’s predictions based on mathematical modeling have been validated by the Virginia team, thereby revealing a strong connection between the circadian clock and cancer.
Researchers said that this research will help explain the cause of different results from numerous anticancer drugs, which are used to normalize the level of p53, when they are administrated at different times and find the most effective dosing times for the drugs.
They also believe that this study will play an important role in identifying the cause of increasing cancer rates in shift-workers whose circadian clocks are unstable and will contribute to the development of more effective treatments for cancer.
Professor Kim said, “This is an exciting thing that my research can contribute to improving the healthy lives of nurses, police officers, firefighters, and the like, who work in shifts against their circadian rhythms. Taking these findings as an opportunity, I hope to see more active interchanges of ideas between biological sciences and mathematical science in Korea.”
This research has been jointly conducted between KAIST and Virginia Tech and supported by the T. J. Park Science Fellowship of POSCO, the National Science Foundation of the United States, and the Young Researcher Program of the National Research Foundation of Korea.
Picture 1. The complex interaction between tumor antigen p53 and Period2 (Per2) which plays a major role in the circadian clock as revealed by mathematical simulations and experiments
Picture 2. A portion of the mathematical model used in the research
Picture 3. Professor Jae Kyoung Kim (third from left) and the Virginia Tech Research Team
2016.11.17 View 8871 -
Professor Seyun Kim Identifies a Neuron Signal Controlling Molecule
A research team led by Professor Seyun Kim of the Department of Biological Sciences at KAIST has identified inositol pyrophosphates as the molecule that strongly controls neuron signaling via synaptotagmin.
Professors Tae-Young Yoon of Yonsei University’s Y-IBS and Sung-Hyun Kim of Kyung Hee University’s Department of Biomedical Science also joined the team.
The results were published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on June 30, 2016.
This interdisciplinary research project was conducted by six research teams from four different countries and covered a wide scope of academic fields, from neurobiology to super resolution optic imaging.
Inositol pyrophosphates such as 5-diphosphoinositol pentakisphos-phate (5-IP7), which naturally occur in corns and beans, are essential metabolites in the body. In particular, inositol hexakisphosphate (IP6) has anti-cancer properties and is thought to have an important role in cell signaling.
Inositol pentakisphosphate (IP7) differs from IP6 by having an additional phosphate group, which was first discovered 20 years ago. IP7 has recently been identified as playing a key role in diabetes and obesity.
Psychopathy and neurodegenerative diseases are known to result from the disrupted balance of inositol pyrophosphates. However, the role and the mechanism of action of IP7 in brain neurons and nerve transmission remained unknown.
Professor Kim’s team has worked on inositol pyrophosphates for several years and discovered that very small quantities of IP7 control cell-signaling transduction. Professor Yoon of Yonsei University identified IP7 as a much stronger inhibitor of neuron signaling compared to IP6. In particular, IP7 directly suppresses synaptotagmin, one of the key proteins in neuron signaling. Moreover, Professor Kim of Kyung Hee University observed IP7 inhibition in sea horse neurons.
Together, the joint research team identified inositol pyrophosphates as the key switch metabolite of brain-signaling transduction.
The researchers hope that future research on synaptotagmin and IP7 will reveal the mechanism of neuron-signal transduction and thus enable the treatment of neurological disorders.
These research findings were the result of cooperation of various science and technology institutes: KAIST, Yonsei-IBS (Institute for Basic Science), Kyung Hee University, Sungkyunkwan University, KIST, University of Zurich in Switzerland, and Albert-Ludwigs-University Freiburg in Germany.
Schematic Image of Controlling the Synaptic Exocytotic Pathway by 5-IP7 , Helping the Understanding of the Signaling Mechanisms of Inositol Pyrophosphates
2016.07.21 View 13596 -
Public Lectures on the Korean Language and Alphabet
The School of Humanities and Social Sciences at KAIST will offer public lectures on the Korean language and alphabet, Hangul, from March 22, 2016 to April 26, 2016.
The lectures, which are entitled “The Riddle of Hangul,” will take place on campus in Daejeon.
A total of six lectures will be held on such topics as the origin of Korean, the grammar of ancient Korean in the Chosun Dynasty (1392-1897), and subsequent developments in contemporary Korean.
Professor Jung-Hoon Kim, who is responsible for organizing the public lecture program, said, “The audience will have an interesting opportunity to understand the history of Korean and its mechanism, while reviewing the unique spelling system of Hangul. I hope many people will show up for these wonderful classes.”
For further information and registration, please visit: http://hss.kaist.ac.kr. All lectures, available only in Korean, are free and open to the public.
2016.03.15 View 10758 -
Dr. Ryu of KAIST Receives the S-Oil Outstanding Paper Award
Dr. Je-Kyung Ryu of KAIST’s Department of Physics has been awarded the S-Oil Outstanding Paper Award for his doctoral dissertation’s originality and applicability.
Professor Tae-Young Yoon of Physics is his doctoral advisor.
The award ceremony took place on November 25, 2015 at the Press Center in Seoul.
This S-Oil Outstanding Paper Award, jointly sponsored by the Korean Academy of Science and Technology (KAST) and the Scholastic University Presidential Association, was established to foster young talented scientists in basic science and to advance the field.
The award is given every other year for each of the fields of physics, chemistry, mathematics, biology, and earth sciences.
With the award, Dr. Ryu received a research grant of USD 8,600.
He discovered, for the first time in the world, how NSF (N-ethylmaleimide-sensitive factor), a protein involved in a vesicular transport in cellular activities, disassembles a SNARE (soluble NSF attachment protein receptor) complex, using a unimolecular biophysics method.
Unlike the existing studies, he proposed a model in which NSF disassembles SNARE complexes at one step, and as a result, provided evidence of how the SNARE complex influenced the fusion of biological membranes.
His research was published in the scientific journal Science issued on March 27, 2015. The title of the paper is “Spring-loaded Unraveling of a Single SNARE Complex by NSF in One Round of ATP Turnover.”
2015.11.27 View 12091 -
Public Lectures by KAIST's Humanities and Social Sciences Research Center
The Humanities and Social Sciences Research Center at KAIST offers public lectures at the International Seminar Hall of the Humanities and Social Sciences building on campus from November 12, 2015 to December 10, 2015. There will be four lectures, all of which will be available in Korean only.
The theme of the lectures is “social issues and strategic solutions.” Experts in various fields including women’s studies, criminal psychology, Go (a Chinese board game) and its philosophy, and Korean studies will participate, offering multifaceted analysis and solutions for social issues in Korea.
Joo-Hee Kim, a researcher at the Korean Women’s Institute of Ewha Women’s University, will lecture on “Problems of Loan Products Exclusively for Women” and discuss the background of "micro-loans" which are often targeted at women, while evaluating the logic of financial corporations behind marketing such products.
Lectures by Professor Ji-Sun Park from the Department of Social Psychology at Ewha Women’s University on “Understanding of Criminal Psychology from Letters,” Professor Soo-Hyun Jeong from the Department of Go at Myeongji University on “Life Lessons and Strategies from Playing Go,” and Professor Seung-Taek Ahn from Kyujanggak Institute for Korean Studies of Seoul National University on “Community Problems in Folk Culture” will follow.
The organizer of the lectures, Professor Jung-Hoon Kim of the Department of Humanities and Social Sciences at KAIST said,
“These lectures will provide local citizens and the KAIST family a wonderful opportunity to understand important social issues from the perspective of social science. It will also serve as a valuable time to think about how our social conflicts could differ from those of other countries, helping us to find solutions.”
To register for these free lectures, go to http://hss.kaist.ac.kr by November 9, 2015.
2015.11.06 View 8446 -
Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award.
Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years.
Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years.
Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells.
Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23 View 15331 -
Nikon Instruments Korea Donates a Fund to KAIST's Department of Biological Sciences
Representatives from Nikon Instruments Korea Co., Ltd., a producer of microscopes and measuring instruments, visited the KAIST campus on September 25, 2015, and donated USD 9,000 to the Department of Biological Sciences at KAIST.
A small ceremony to mark the donation took place at the department’s conference room.
In the picture from left to right were Professor Won-Do Heo, Department Head Byung-Ha Oh, Professor Sangyong Jon, President Sam-Sup Jang of Korea Instech, and Director Ik-Soo Yoo of Nikon Instruments Korea.
The department announced that the fund would be used to build its new research center to house the state-of-the-art research equipment and tools for the development of new medicine.
2015.10.03 View 6341