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Twelve Years Later, KAIST’s Undergraduate Research Program Demonstrates Its Lasting Impact on Developing World-Class Talent
KAIST’s undergraduate research programs have helped launch the careers of professors at world-leading universities and experts in global industry in just over a decade. Three students featured as undergraduate researchers in 2014 have since built distinguished careers: two are now professors at leading universities in the United States, while the third works as an open innovation expert at a global pharmaceutical company. Their career paths demonstrate the lasting impact of KAIST’s Undergraduate Research Participation Program (URP) on talent development.
KAIST (President Choongsik Bae) announced on Aug 9 that its Undergraduate Research Participation Program (URP), which enables undergraduate students to formulate their own research questions and experience the entire research process in faculty laboratories, has become a cornerstone of the Institute’s efforts to develop world-class researchers and science and technology professionals.
URP is one of KAIST’s flagship research education programs. It allows undergraduate students to conduct actual research projects in faculty laboratories and directly experience the entire research process, from developing research ideas to conducting experiments, analyzing data, and writing papers. Operated with support from the Ministry of Science and ICT, the program has conducted a total of 679 research projects over the past five years. Through these projects, students have generated a wide range of research outcomes, including publications in international academic journals, patent applications, and awards at international conferences.
“KAIST has steadily expanded research-centered education so that undergraduate students can formulate their own questions and create new knowledge in a world-class research environment,” said President Choongsik Bae. “We will continue to provide strong support through URP and other research programs enabling students to take on challenges without fear of failure and grow into science and technology leaders who drive innovation at universities and in industry around the world.”
A notable example can be found in the laboratory of Professor YongKeun Park in the Department of Physics. In 2014, KAIST highlighted the achievements of undergraduate researchers in Professor Park’s laboratory in an article titled “Professor YongKeun Park Produces Undergraduate Students with International Achievements.” The three students featured at the time have since grown into world-class researchers and professionals, each pursuing a different career in academia or industry.
Sangyeon Cho began working in a laboratory during his first year at KAIST and completed more than 30 credits of research courses by the time he graduated. One of the two first-author papers he published as an undergraduate, his review article on optical imaging techniques for malaria was featured on the cover of Trends in Biotechnology in 2012. He later earned his Ph.D. through the Harvard-MIT Health Sciences and Technology program and served as an assistant professor at Harvard Medical School before joining Rice University as an assistant professor in July 2026. He currently studies technologies that use the world’s smallest nanolasers to track individual cancer cells and therapeutic cells over extended periods.
YoungJu Jo began conducting research combining microscopy and artificial intelligence as an undergraduate, building an interdisciplinary foundation early in his career. His research at the time on virtual staining and diagnosis was published in journals including Nature Cell Biology and Science Advances. He later conducted neuroscience research at Stanford University and published a first-author paper that was featured on the cover of Cell in 2022. In July 2026, Jo joined UC Berkeley as an assistant professor, where he is developing next-generation brain-computer interface (BCI) technologies capable of delivering complex information to the brain.
Seoeun Lee carried the research mindset she developed as an undergraduate into a career in industry. After earning her Ph.D. from Columbia University and working at Boston Consulting Group, she joined global pharmaceutical company Eli Lilly. She currently leads External Innovation activities in the company’s neuroscience division, identifying and pursuing collaborations with promising biotechnology companies through mergers and acquisitions, licensing, partnerships, and other arrangements. Her career demonstrates that undergraduate research experience can lead not only to traditional research careers but also to roles in strategy and collaboration within science- and technology-based industries.
Although the three alumni ultimately pursued careers in different settings—universities and industry—their journeys began in much the same way. During their first or second year as undergraduates, they independently sought out opportunities in laboratories and experienced research that began with questions they were personally curious about rather than merely executing assigned experiments. As an undergraduate, Sangyeon Cho conceived an idea for a super-resolution microscope after seeing a streetlight turn on while walking back to his dormitory late at night. Together with Professor Park, he developed this initial curiosity into a scientific question and ultimately into a research paper.
This undergraduate research culture continues at KAIST today. In 2023, research on GOBI, a methodology for estimating causal relationships in time-series data, involving undergraduate Seho Park as first author, was published in Nature Communications.
In 2024, undergraduate Taesik Youn, serving as first author, conducted the world’s first total synthesis of the natural product securinine G, which has potential applications in cancer treatment and drug development. In 2025, two studies involving undergraduate Minjae Kim were published. His co-first-authored research on a wearable carbon dioxide sensor for real-time breath monitoring appeared in Device, a Cell Press journal, while his lead-author study on OLED displays was published in Nature Communications. Undergraduate Jaehong Cho received both the Best Paper Award and the Distinguished Artifact Award at an IEEE international conference based on his URP research. Through URP, undergraduate-led, world-class research achievements continue to emerge across diverse fields, including drug development, wearable devices, displays, and artificial intelligence. These students are not only publishing in internationally recognized journals and receiving awards at international conferences but also developing advanced research capabilities early in their academic careers.
“These students did not become outstanding researchers through mentorship alone,” said Professor YongKeun Park. “I am grateful that KAIST has created an environment in which faculty members can conduct research alongside such exceptional students. A professor’s role, I believe, is to help students further develop the tremendous potential they already possess.”
“Research is about discovering something new, which means that undergraduate and graduate students begin from the same starting point,” he added. “What ultimately shapes a researcher is the depth of their engagement, their persistence in the face of setbacks, and their ability to formulate questions independently and seek out answers.”Questions first explored in undergraduate laboratories 12 years ago are now driving new research and innovation at universities and companies around the world. KAIST will continue to expand research opportunities through URP so that students can pursue their own questions and create new knowledge.
2026.08.10 View 401 -
KAIST-NVIDIA Establish Asia's First AI Joint Research Lab, Accelerating Korea's AI Innovation
KAIST and NVIDIA establish Asia's first AI joint research lab between NVIDIA and a university to advance next-generation agentic AI tailored to the Korean language and domestic industries.
KAIST (President Choongsik Bae) announced on July 24 that it will establish the NVIDIA-KAIST Joint AI Research Lab at the Kim Jaechul Graduate School of AI with the global AI computing giant NVIDIA. The two organizations will conduct joint research on next-generation core AI technologies.
"This collaboration marks the starting point of a strategic partnership between KAIST and NVIDIA that combines world-class AI research talent with cutting-edge AI infrastructure," said President Choongsik Bae. “We will build Korea's leading global AI research hub and lead the way in developing next-generation foundational AI technologies and cultivating world-class AI talent."
Through this partnership, KAIST and NVIDIA will build a joint research framework covering agentic AI models and systems specialized for the Korean language and Korean industries. The two organizations will build a long-term research collaboration framework to develop foundational AI technologies for Korea, cultivate global talent, and strengthen industrial competitiveness.
The NVIDIA-KAIST AI Joint Research Lab, to be established at the Kim Jaechul Graduate School of AI, will operate as a global research hub developing agentic AI models and AI agent systems tailored to Korea's language and industrial needs.
The two organizations plan to combine NVIDIA’s full-stack AI technologies and Nemotron open models, and the computing infrastructure of local NVIDIA Cloud Partners with the world-class scientific talent at KAIST.
The $300 million collaboration will proceed over an initial five-year period, including $50 million per year in compute contributions. Researchers participating in the joint lab will gain access to the latest NVIDIA AI computing infrastructure through local NVIDIA Cloud Partners.
The joint lab will fund at least 10 KAIST researchers annually and provide each with internship opportunities at NVIDIA. In addition, NVIDIA plans to hire exceptional Korean researchers for full-time positions. Together, these efforts will create stronger pathways for Korea's top AI talent to pursue ambitious research, build long-term careers, and deepen global collaboration between academia and industry.
The joint lab will be led by Dr. Hyunwoo Kim, currently at NVIDIA, who will join the Kim Jaechul Graduate School of AI as a professor next month. Dr. Kim will set the lab's research direction and oversee collaboration between local and international researchers.
"Korea is home to leading AI researchers and has one of the world's most advanced technology ecosystems," said Bill Dally, chief scientist and senior vice president of research at NVIDIA. "The NVIDIA-KAIST AI Joint Research Lab will provide a foundation for pioneering the next frontier of AI research and accelerating the development of AI models and agent systems for Korea’s industries, language, and future"
Dr. Hyunwoo Kim, incoming faculty member at the KAIST Kim Jaechul Graduate School of AI, who will serve as head of the joint NVIDIA-KAIST lab upon joining KAIST, said,
“AI research is entering a new era — one that requires frontier talent, large-scale infrastructure and deep collaboration across academia and industry.” He added, “Together, NVIDIA and KAIST Kim Jaechul Graduate School of AI will pursue ambitious work that helps Korea attract and retain top AI scientists while building lasting ties with NVIDIA's global research organization.”
Song Chong, Head of the KAIST Kim Jaechul Graduate School of AI, said, "This joint lab is a new industry-academia collaboration model that combines world-class research talent, AI infrastructure, and the research capabilities of a global company." He added, "We will develop core agentic AI technologies specialized for the Korean language and Korean industries and build an ecosystem where outstanding researchers can carry out world-class research from within Korea."
Check out NVIDIA's official blog post on this historic partnership here.
2026.07.24 View 3722 -
KAIST: Dementia-Causing Substance Turns On a Therapeutic “Switch”
A substance that worsens dementia has become a “switch” that initiates treatment. KAIST researchers have developed a new therapeutic approach that uses hydrogen peroxide (H₂O₂), a reactive oxygen species that damages cells and increases in the brains of patients with Alzheimer’s disease, to activate a drug selectively in diseased brain tissue. The team also confirmed improvements in cognitive function through animal experiments, presenting a new possibility for next-generation dementia treatment.
KAIST announced on the 2nd that a research team led by Professor Mi Hee Lim of the Department of Chemistry, in collaboration with Professor Mingeun Kim of Chonnam National University, Dr. Chul-Ho Lee and Dr. Kyoung-Shim Kim of the Korea Research Institute of Bioscience and Biotechnology, and Dr. Young-Ho Lee of the Korea Basic Science Institute, has developed a prodrug that is activated selectively in the diseased brain in Alzheimer’s disease and confirmed its therapeutic effects through animal experiments.
A prodrug is a drug that initially has minimal therapeutic effect but is converted into an active therapeutic agent only under specific conditions inside the body. In this study, the prodrug was designed to be activated only when it encounters hydrogen peroxide, which increases in the brains of patients with Alzheimer’s disease, allowing it to function as a “smart therapeutic agent” that selectively acts in diseased brain tissue.
In the brains of Alzheimer’s disease patients, hydrogen peroxide, which damages cells, is elevated above normal levels. Until now, it has generally been regarded only as a harmful substance that should be removed. However, the research team devised a method to use it instead as a signal that activates a drug.
The prodrugs developed by the research team, BE-1 and BE-2, are designed to remain minimally reactive in a healthy brain. However, when they encounter hydrogen peroxide in a brain affected by dementia, they are converted into active therapeutic compounds, AP-1 and AP-2. Through this process, they reduce reactive oxygen species, including hydrogen peroxide, while also preventing amyloid beta (Aβ) peptides — peptides known as a major cause of dementia that accumulate in the brain and damage nerve cells — from aggregating into highly toxic clumps.
Using advanced analytical techniques, the research team confirmed that the activated drug alters the morphology of amyloid beta aggregates and suppresses their growth into large aggregates.
These effects were also confirmed in Alzheimer’s disease mouse models. The drug crossed the blood-brain barrier (BBB), a protective barrier that controls whether substances in the blood can enter the brain, and was converted into the therapeutic compound inside the diseased brain. In mice that received long-term drug administration, oxidative stress in the hippocampus, which is responsible for memory, was reduced, and amyloid beta accumulation in the brain also decreased. In behavioral experiments assessing the ability to recognize new objects and navigate mazes, cognitive function was also found to improve.
This study is significant in that the drug was designed to operate only where needed by using the environment of the diseased brain itself. This approach presents a new strategy for dementia treatment that can enhance therapeutic efficacy while reducing side effects, and it is expected to be applicable to the treatment of other neurodegenerative diseases, such as Parkinson’s disease.
Professor Mi Hee Lim of KAIST’s Department of Chemistry said, “This study is meaningful in that hydrogen peroxide, which had previously been regarded only as something to be eliminated, was used as a signal to activate a drug. We expect this strategy, which activates drugs in diseased tissue, to become a new platform for treating complex diseases such as Alzheimer’s disease more safely and effectively.”
This study was co-first-authored by Jimin Lee and Eunseo Hong, Ph.D. candidates in KAIST’s Department of Chemistry, and was published online on May 31, 2026, in the international journal Small (Impact Factor: 12.1, top 10% in the field of chemistry).
※ Paper title: A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer’s Disease
DOI: 10.1002/smll.74013
This research was supported by the National Research Foundation of Korea’s Leader Researcher Program, Global Leading Research Center Program, Sejong Science Fellowship, Graduate Student Research Encouragement Program, and institutional programs of KRIBB and KBSI.
2026.07.03 View 1702 -
KAIST Study Provides First Large-Scale Empirical Analysis of Dual-Use Research and Security Oversight
<Professor Seokbeom Kwon>
A new analysis of approximately 600,000 research papers reveals structural limits to single-country security oversight of dual-use research and identifies trade-offs that policymakers face when strengthening such oversight.
KAIST (President Kwang Hyung Lee) announced today that Professor Seokbeom Kwon of the School of Business and Technology Management has published a large-scale empirical analysis examining the structural limitations of tightening security oversight on dual-use research and its potential cost to scientific progress. The study appears in Science on June 5, 2026.
Dual-use research (DUR) refers to scientific research that has both legitimate civilian applications—such as vaccine and treatment development—and potential security-sensitive applications, such as biological weapons or bioterrorism. Examples include research on viral transmission mechanisms or pathogen behavior.
< Research Image (AI-Generated) >
The United States has been strengthening security oversight of dual-use research. Most recently, Executive Order 14292, signed in May 2025, intensified federal oversight of biological research with potential security implications, including dangerous gain-of-function research. The U.S. government also has extended the policy definition of the dual-use research to include broader categories in addition to the gain-of-function research. However, existing policy dialogues have relied primarily on anecdotal evidence and historical case studies.
U.S. ex-ante security oversight institutions are based on National Security Decision Directive 189 (NSDD-189) and apply when the federal government is involved in research. Therefore, research conducted without federal government involvement effectively falls outside the jurisdiction of this oversight.
Professor Seokbeom Kwon developed a new analytical methodology combining the U.S. Patent and Trademark Office’s multi-stage security review process with patent-paper citation data, and analyzed approximately 600,000 research papers. The work has been recognized in academia for shifting discussions of dual-use research, which had previously relied largely on case-based analysis, toward large-scale empirical analysis.
The analysis showed that dual-use research consistently has greater scientific impact than comparable research. This means that research subject to the security oversight tends to play an important role in scientific progress and technological innovation.
In addition, the share of dual-use research directly involving the U.S. federal government decreased from about 41% in 1981 to about 22% in 2005, while the share involving foreign institutions increased from 35% to 54% over the same period. This shows that while U.S. security oversight mechanisms based on NSDD-189 have been applied to domestic research, the share of overseas dual-use research has continued to expand.
< Comparison of the Scientific Significance of Dual-Use Research >
Professor Seokbeom Kwon explained, “Strengthening security oversight on dual-use research by a single country alone may impose disproportionate costs on domestic science, while having structural limits in preventing the development of equally important research conducted overseas,” adding, “To achieve both scientific progress and national security, international cooperation and balanced policy design could contribute to mitigating these structural tensions.”
This study provides data-based evidence for international policy discussions surrounding dual-use research. In particular, it is expected to serve as an important reference for future discussions on research security regulation and global cooperation systems not only in biotechnology, but also in advanced technology fields that may be connected to security concerns, such as artificial intelligence (AI) and quantum technology.
This study was published as a sole-author paper by Professor Seokbeom Kwon in Science on June 5, 2026.
※ Paper title: “Dual-use research under scrutiny,” DOI: 10.1126/science.aee2479
This research was supported by the National Research Foundation of Korea’s Humanities and Social Sciences Young Researcher Support Program (2025S1A5A8009362).
2026.06.05 View 1155 -
Distinguished Professor Sang Yup Lee Receives the AIBN Translational Research Award from the University of Queensland, Australia
<Distinguished Professor Sang Yup Lee immediately after receiving the AIBN Medal (AIBN Translational Research Award)>
KAIST announced on February 9th that Sang Yup Lee, Distinguished Professor of Chemical and Biomolecular Engineering (and Vice President for Research), was presented with the AIBN Medal (AIBN Translational Research Award) on February 3rd (local time) at the Australian Institute for Bioengineering and Nanotechnology (AIBN), located at the University of Queensland (UQ) in Brisbane, Australia.
The AIBN Medal is awarded to recognize translational research achievements that extend biotechnological research into industrial and social value. It is often described as an award for "achievements that do not let research end in the laboratory." Rather than focusing solely on the number of papers or citations, the award prioritizes industrial applicability, technology dissemination, international cooperation, and social impact. It is a symbolic global award in the field of translational research presented by AIBN, a world-class research hub for synthetic biology, metabolic engineering, and biomanufacturing. The medal was personally presented by Professor Sue Harrison, Deputy Vice-Chancellor (Research) at the University of Queensland.
<Professor Sue Harrison, Deputy Vice-Chancellor of UQ, personally presenting the medal>
During his commemorative lecture, Distinguished Professor Sang Yup Lee spoke on the topic of "Systems Metabolic Engineering for Chemical Production," presenting a future vision for sustainable biomanufacturing and synthetic biology technologies.
<Vice President for Research giving the award lecture on Systems Metabolic Engineering for Chemical Production>
For approximately 32 years at KAIST, Distinguished Professor Sang Yup Lee has pioneered research in metabolic engineering, synthetic biology, and systems biotechnology. To date, he has accumulated world-class research achievements, including 798 papers in international journals, 868 patents (registered and filed), over 3,000 presentations at domestic and international conferences, and approximately 690 keynote and invited lectures.
Furthermore, he has contributed to establishing the academic framework of the field through numerous publications, such as Metabolic Engineering, Systems Biology and Biotechnology of Escherichia coli, and Systems Metabolic Engineering.
In its official announcement, AIBN stated the background for the award: "Distinguished Professor Sang Yup Lee is a world-renowned scholar in the field of systems metabolic engineering who has made continuous and meaningful contributions not only to academic influence but also to the University of Queensland and the Australian research ecosystem." Notably, Professor Lee played a key role in establishing research strategies during the early days of AIBN (2006–2007). His collaboration has since expanded from sugar-based biomanufacturing to synthetic aviation fuels and waste-gas fermentation-based bioprocessing.
This collaboration led to global joint research with entities such as Amyris (a US-based bio-chemical and fuel company), UC Berkeley, LanzaTech (a global leader in waste-gas fermentation), and SkyNRG (a Dutch company leading the development of Sustainable Aviation Fuel, SAF). These efforts served as a vital foundation for the University of Queensland to become Australia’s representative research hub in synthetic biology and systems metabolic engineering.
Professor Lee is an International Member of the National Academy of Sciences (NAS) and the National Academy of Engineering (NAE) in the US, a Foreign Member of The Royal Society in the UK, and a Foreign Member of the Chinese Academy of Engineering. He also serves as the Co-Chair of the Global Future Council on Biotechnology for the World Economic Forum (WEF), continuing his international activities across academia, policy, and industry.
In his acceptance speech, Vice President Sang Yup Lee remarked, "I believe this AIBN Medal is not just an individual achievement, but the fruit of long-standing cooperation between researchers from KAIST, UQ, and Korea and Australia. It is a meaningful award that demonstrates how research in systems metabolic engineering and synthetic biology can lead to solutions for sustainable industry and social issues." He added, "Moving forward, I will continue to strengthen global research cooperation and translational research to ensure that biotechnology provides tangible value to human life."
KAIST President Kwang Hyung Lee commented, "This award goes beyond the personal excellence of Distinguished Professor Sang Yup Lee; it is a case where KAIST’s research capabilities and international cooperation strategies have been recognized globally. KAIST will continue to lead translational research where results spread to industry and society, contributing to the sustainable bio-industry and the resolution of global challenges through cooperation with global partners."
Meanwhile, Distinguished Professor Sang Yup Lee was originally named the inaugural recipient of the 1st AIBN Medal in 2016. However, the official ceremony was delayed due to scheduling conflicts and the COVID-19 pandemic, leading to his attendance and formal receipt of the award nearly 10 years later.
2026.02.09 View 2734 -
KAIST Proposes a Multinational AI Cooperation Strategy Beyond U.S.–China Dominance
2026.01.19 View 3195 -
Chairman Jae-Chul Kim of Dongwon Group Donates a Total of 60.3 Billion Won to KAIST
<Jae-Chul Kim, Honorary Chairman of Dongwon Group>
"In the era of AI, a new future lies within the sea of data. I ask that KAIST leaps forward to become the world's No. 1 AI research group." — Jae-Chul Kim, Honorary Chairman of Dongwon Group
KAIST announced on January 16th that Honorary Chairman Jae-Chul Kim of Dongwon Group has pledged an additional 5.9 billion KRW in development funds to foster Artificial Intelligence (AI) talent and strengthen research infrastructure, bringing his total contribution to 60.3 billion KRW. This marks his second additional donation since 2020, continuing his steadfast support for strengthening South Korea's national competitiveness in the field of AI.
Through his initial donation in 2020, Chairman Kim established the 'Kim Jaechul Graduate School of AI' at KAIST, urging the university to secure world-class capabilities. Upon hearing that KAIST’s AI research level ranked 5th among global universities over the past five years (2020–2024), Chairman Kim requested that the university strive to reach the No. 1 spot in the world.
In response, President Kwang Hyung Lee explained, "To surpass Carnegie Mellon University (CMU), which is currently evaluated as the world’s best with an AI faculty of about 45, the KAIST Graduate School of AI needs to expand its faculty to over 50 and construct a dedicated research building." Chairman Kim responded by saying, "I will build the building," and this latest donation is a fulfillment of that promise.
This third pledge of 5.9 billion KRW was decided to cover the projected budget shortfall as the design of the AI Education and Research Building enters full-scale development.
The AI Education and Research Building will be a facility with 8 floors above ground and 1 basement level, covering a total floor area of 18,182 m² (approx. 5,500 pyeong). It is scheduled for completion in February 2028. Once finished, it will serve as a global AI research hub housing 50 faculty members and 1,000 students.
Since the 2021 academic year, KAIST has been selecting 60 Master’s and 10 Doctoral students annually as 'Dongwon Scholars' outside of the regular quota for a period of 10 years. While the tuition and research incentives for the first three years were supported by the donation, KAIST has been utilizing its own budget since the 2024 academic year to ensure students can focus entirely on their research.
Moving forward, the Kim Jaechul Graduate School of AI plans to build a world-class faculty and operate systematic Master's and Doctoral programs to cultivate global AI leaders. In addition to technical expertise, the school will offer educational programs focused on character and holistic development, leading the charge in strengthening Korea's AI competitiveness.
Honorary Chairman Jae-Chul Kim stated, "I hope this donation serves as a small 'priming water' for South Korea to leap forward as an AI powerhouse. I look forward to seeing global core talents grow here and contribute to our national strength."
President Kwang Hyung Lee expressed his gratitude, saying, "Chairman Kim’s unwavering support is the greatest driving force for KAIST to secure global AI sovereignty. We will ensure the Kim Jaechul Graduate School of AI becomes a mecca where the world's best AI minds gather to innovate, honoring the Chairman’s vision."
2026.01.16 View 3285 -
KAIST Proposes AI-Driven Strategy to Solve Long-Standing Mystery of Gene Function
<(From Left) Distinguisehd Professor Sang Yup Lee, Dr. Gi Bae Kim, Professor Bernhard O. Palsson>
“We know the genes, but not their functions.” To resolve this long-standing bottleneck in microbial research, a joint research team has proposed a cutting-edge research strategy that leverages Artificial Intelligence (AI) to drastically accelerate the discovery of microbial gene functions.
KAIST announced on January 12th that a research team led by Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering, in collaboration with Professor Bernhard Palsson from the Department of Bioengineering at UCSD, has published a comprehensive review paper. The study systematically analyzes and organizes the latest AI-based research approaches aimed at revolutionizing the speed of gene function discovery.
Since the early 2000s, when whole-genome sequencing became a reality, there were high expectations that the genetic blueprint of life would be fully decoded. However, even twenty years later, the roles of a significant portion of genes within microbial genomes remain unknown.
While various experimental methods—such as gene deletion, analysis of gene expression profiles, and in vitro activity assays—have been employed, discovering gene functions remains a time-consuming and costly endeavor. This is primarily due to the limitations of large-scale experimentation, complex biological interactions, and the discrepancy between laboratory results and actual in vivo responses.
To overcome these hurdles, the research team emphasized that an AI-driven approach combining computational biology with experimental biology is essential.
In this paper, the team provides a comprehensive overview of computational biology approaches that have facilitated gene function discovery, ranging from traditional sequence similarity analysis to the latest deep-learning-based AI models.
Notably, 3D protein structure prediction technologies such as AlphaFold (developed by Google DeepMind) and RoseTTAFold (developed by the University of Washington) have opened new doors. These tools go beyond simple functional estimation, offering the potential to understand the underlying mechanisms of how gene functions operate. Furthermore, generative AI is now extending research boundaries toward designing proteins with specifically desired functions.
Focusing on transcription factors (proteins that act as genetic switches) and enzymes (proteins that catalyze chemical reactions), the team presented various application cases and future research directions that integrate gene sequence analysis, protein structure prediction, and diverse metagenomic analyses.
<Schematic illustration of computational biology methods for enzyme function prediction>
2026.01.12 View 3559 -
KAIST–Daekyo, Opening of the Cognitive Enhancement Research Center Lounge
< Group photo of officials at the opening ceremony of the KAIST–Daekyo Cognitive Enhancement Research Center Lounge >
KAIST held the opening ceremony for the ‘KAIST–Daekyo Cognitive Enhancement Research Center Lounge,’ jointly established with Daekyo, at the Meta-Convergence Hall on the Daejeon main campus last Saturday, the 10th.
This lounge was established through an in-kind donation by Daekyo for space creation as part of research cooperation. It was designed as a base space to more systematically operate brain development and cognitive function enhancement research that KAIST and Daekyo have been jointly promoting, and to share research results with society. Through this event, KAIST introduced the achievements of its research cooperation to date and provided a forum to explore the future directions of education and brain science.
Key KAIST officials, including Kyun Min Lee, Vice President for Provost and Academic Affairs, and Dae-Soo Kim, Dean of the College of Life Science and Bioengineering, as well as officials from both organizations, including Ho-joon Kang, CEO of Daekyo, attended the event to celebrate the opening of the lounge.
Since signing a Memorandum of Understanding (MOU) for industry-academic research cooperation with Daekyo in 2023, our university has been jointly conducting research on cognitive function enhancement and mental health across the entire life cycle—from infants to adults and seniors—based on brain and cognitive science. The cooperation continues to expand these research results into educational content and solutions.
An official from Daekyo stated, "The Cognitive Enhancement Research Center Lounge is a symbolic space for the research cooperation accumulated by both organizations, and it is highly meaningful to be able to communicate directly with customers and share research results here. Moving forward, Daekyo will continue to expand its cooperation with KAIST to prove the value of scientific and systematic education."
Kyun Min Lee, Vice President for Provost and Academic Affairs, said, "The opening of this lounge is significant in that a space for industry-academic cooperation research was created through Daekyo’s donation. Based on this space, KAIST will strive to share the achievements of brain and cognitive science research with society and contribute to the field of education."
2026.01.12 View 1680 -
KAIST Drives National Competitiveness with a Dual-Impact Model for AI Research and Regional Innovation
<Photo of KAIST Students>
KAIST announced on December 9th that it will accelerate the nurturing of world-class scientific talent and regional balanced development. This follows the government's recent announcement on 'Leaping to a Science and Technology Powerhouse, the Republic of Korea, Where People Dream of Becoming Science and Technology Professionals Again (Nov. 7),' which explicitly named the four major science and technology institutes, including KAIST, as AX (AI Transformation) innovation hubs and key leading institutions for regional innovation.
This move aligns with the policy direction of President Jae-myung Lee. On November 4th, President Jae-myung Lee stated in a Cabinet meeting, "STEM talent is the core of national competitiveness," adding that "the increase in applicants for early admissions to the four major science and technology institutes is a very desirable phenomenon for the nation's future." In particular, the President requested that the government "actively seek concrete policies, such as expanding the allowance for transfers between STEM fields, increasing budget support, securing excellent faculty, and upgrading research and education infrastructure, because science and technology institutes can also significantly contribute to regional balanced development."
KAIST President Kwang Hyung Lee stated, "Strengthening AI research capabilities and regional balanced development is a Dual-Impact Model for AI Research and Regional Innovation that boosts national competitiveness." He confirmed that through the government's policy direction, the innovation philosophy KAIST has pursued—that 'the region is national competitiveness'—has been established as a core national direction.
In reality, KAIST continues to firmly play a central role in nurturing the talent that sustains South Korea's science and technology sector, even amid the deepening phenomenon of students flocking to medical schools. The increase in early admission applicants to the four science and technology institutes proves the successful establishment of education and research foundations where students can choose the dream of becoming science and technology professionals instead of doctors. To accelerate this trend, KAIST is focusing on establishing a National AI Research Lab and pioneering the next-generation AI research paradigm with the goal of becoming one of the top three AI powerhouses (G3) globally.
Our university was selected not only to lead the development of the next-generation bio-AI model 'K-Fold'—which surpasses Google DeepMind—and as a key participating institution in the Lunit consortium, but also as a core research team in the national AI flagship project, the 'Generative AI Leading Talent Cultivation Program.' Through discovering research topics that reflect diverse technological demands from industries, nurturing advanced AI talent, and demonstrating research outcomes in industrial settings, KAIST is being reborn as a field-ready leader guiding the AI Transformation (AX) across all of South Korea's industries.
KAIST's AI research competitiveness has also been officially recognized overseas. NVIDIA CEO Jensen Huang personally introduced KAIST as an "Amazing University" during his keynote speech at the 2025 APEC CEO Summit (Oct. 31), highly evaluating KAIST's world-class research capabilities and global collaboration potential.
Regional innovation is also gaining momentum. Our university is expanding physical AI-based research infrastructure in regions like Jeonbuk and Gyeongnam, centered around its main campus in Daejeon. Through the AI and robot-based 'Robot Valley Project' and the 'Global Innovation Startup Growth Hub Project,' in cooperation with Daejeon City, KAIST is supporting the advancement of local industries and the growth and global expansion of startups.
<ANGEL SUIT, a gait-training robot>
In particular, Sovagen—a bio-company founded on the technology of Professor Jeong Ho Lee of the KAIST Graduate School of Medical Science—recently succeeded in an overseas technology transfer of an RNA new drug for epilepsy valued at 750 billion KRW, proving a virtuous cycle model of innovation where university research translates into actual industry success.
Furthermore, the foundation for future talent development is being strengthened through efforts like promoting a culture of challenging research via the 'Failure Lab,' and early nurturing of outstanding talent through the 'Junior KAIST' and '3+4 TUBE Programs.' While setting the direction for regional university innovation through the specialized and performance-centric 'KAIST Model,' the university is also taking the lead in popularizing science and fulfilling its social responsibilities.
President Kwang Hyung Lee emphasized, "We will continue to pursue the expansion of the AI research budget and the establishment of international joint research infrastructure through close cooperation with the government." He concluded, "We will cultivate young talents who have chosen the future to be the main players in South Korean science and technology, fulfilling our central role in the 'AI Powerhouse Republic of Korea,' where the nation and the regions grow together."
2025.12.09 View 4087 -
KAIST, National Quantum Fab Research Institute Opening Ceremony and Research Building Groundbreaking Ceremony Held
<Groundbreaking Ceremony Shovel Scene for the KAIST National Quantum Fab Research Building>
KAIST announced on December 3rd that it held the opening ceremony for the National Quantum Fab Research Institute and the groundbreaking ceremony for the Quantum Fab Research Building at the KAIST main campus in Daejeon, officially commencing the construction of the nation's core infrastructure to enhance South Korea's quantum technology competitiveness.
The event began with a progress report and introduction of the institute by Yong Hoon Cho, Director of the Quantum Fab Research Institute, followed by a groundbreaking ceremony to mark the official start of the Quantum Fab Research Building's construction and an unveiling of the plaque. Approximately 50 officials attended the event, including Jang-woo Lee, Mayor of Daejeon, Kwang Hyung Lee, President of KAIST, and the presidents of the National Nanofab Center and the Korea Research Institute of Standards and Science, representing government, local government, and collaborating organizations.
<Plaque-Unveiling Scene at the Opening of the KAIST National Quantum Fab Research Institute>
Since being selected as the lead institution for the Quantum Fab in a competition held by the Ministry of Science and ICT and the Institute for Information & Communications Technology Planning & Evaluation last year, our university secured a commitment of 20 billion KRW from the Daejeon Metropolitan City for construction costs and completed the institute's establishment and design. The new Quantum Fab Research Building, with a total floor area of 2,498 ㎡, is targeted for completion in 2027.
The new building will house South Korea's largest specialized, open-access cleanroom fab for quantum devices. A total of 45 billion KRW or more will be invested by 2031, including national funds, local government funds, and KAIST's budget. Over 37 units of advanced equipment will be installed in the 1st and 3rd-floor FAB cleanrooms in stages, along with stability facilities such as Class 100-1,000 cleanliness standards, constant temperature/humidity, and emergency power supply.
The KAIST Quantum Fab operates on a fully open-access system allowing researchers to directly carry out processes. It will support processing technologies for various quantum platforms, including photons, point defects, and neutral atoms, and will also enhance user programs such as training and workshops. Phase 1 service began in July of this year, and Phase 2 full-scale operation, based on the newly installed equipment, will start in 2028.
Jang-woo Lee, Mayor of Daejeon, stated, "The KAIST open-access Quantum Fab is a core platform that will lead the industrialization of quantum technology in South Korea," adding, "Especially since the US and South Korea have designated quantum computing as a strategic field in their $350 billion technology cooperation package, Daejeon's role is becoming even more crucial."
Director Yong-Hoon Cho said, "Through a user-centric process support system, we will play a central role in the national quantum research ecosystem," adding, "Based on our research capabilities and support system, we will expand industry-academia-research cooperation and aim to leap forward as a pilot quantum fab."
President Kwang Hyung Lee remarked, "Quantum science and technology is a core strategic area that will determine the future technological hegemony," and "We will take this opening and groundbreaking ceremony as an opportunity for industry, academia, research, and government to join forces and strengthen the competitiveness of the national quantum ecosystem."
KAIST plans to focus on establishing a self-sustainable virtuous cycle system centered around the Quantum Fab, and will further dedicate efforts to enhancing national strategic technology competitiveness through the nurturing of specialized talent and the development of processing technologies for each platform.
<Bird’s Eye View of the KAIST National Quantum Fab Research Building>
2025.12.04 View 4305 -
Imdang Scholarship and Culture Foundation Donates 500 Million Won to Modernize KAIST's Space Research Infrastructure
< Photo of the Chung Mong-Hun Uri-Star Research Building at the Satellite Research Center >
KAIST announced on the Novemnber 21st that it received a donation of 500 million won from the Imdang Scholarship and Culture Foundation and will proceed with an environmental improvement project for the 'Chung Mong-Hun Uri-Star Research Building' at the Satellite Research Center on the main campus in Daejeon.
The Imdang Scholarship and Culture Foundation is a non-profit scholarship foundation established in 2005 by Chairwoman Moon-Hee Kim, the mother of Hyundai Group Chairwoman Jeong-Eun Hyun. Currently, Executive Director Ji-Yi Chung of Hyundai Movex, Chairwoman Hyun's eldest daughter, serves as the Chairwoman of the Foundation. The foundation has been carrying out various projects over three generations to promote education, culture, arts, sports, and nurture talent.
This donation from the Imdang Scholarship and Culture Foundation once again brings the special and long-standing relationship between KAIST and the Hyundai Group into the spotlight.
The 'Chung Mong-Hun Uri-Star Research Building,' located on the main KAIST campus in Daejeon, was established with a donation from the late Mong-Hun Chung, former Chairman of the Hyundai Group and husband of Chairwoman Hyun, to foster the development of domestic space research. This enabled the launch of the nation's first dedicated university-affiliated space research organization. Following this, Chairwoman Hyun also continued to show special interest and affection for research support projects. The research building was named its current name in 2008 to commemorate the 5th anniversary of the passing of the late Chairman Mong-Hun Chung. In this way, the partnership between Hyundai and KAIST is regarded as a healthy example of corporate social contribution, where a company participates in the development of the knowledge ecosystem and the nurturing of talent.
The KAIST Satellite Research Center, housed in the 'Chung Mong-Hun Uri-Star Research Building,' was established in 1989 as the nation's first dedicated university-affiliated space research organization. Starting with 'Uribyol-1,' which signaled the start of South Korea's space development, it has led the development of various satellites, including next-generation small satellites and ultra-small satellite constellations, based on independent domestic technology, growing into a world-class small satellite research institution.
Currently, about 80 researchers are stationed at the research building, dedicated to developing cutting-edge small satellite technology. However, the inconvenience of transporting research equipment due to the absence of an elevator and the lack of accessibility for mobility-impaired individuals have been persistent issues.
KAIST plans to use this donation to install an elevator connecting the basement floor to the 4th floor above ground. This will increase the efficiency of transporting research equipment while providing a convenient movement environment for both visitors and researchers.
Furthermore, the public relations hall, which has been operating since 2008, will be renovated into an experiential exhibition space, applying the latest digital display techniques to allow visitors to see KAIST's space research achievements and history at a glance. Visited by over 1,000 people annually, including domestic and international students, the general public, research institutions, businesses, and government officials, this space is expected to become a place for experiencing and sharing KAIST's space technology development process and future vision.
To commemorate this project and express gratitude for the sponsorship, our university will hold a plaque of appreciation ceremony at the KAIST Seoul Campus President's Office on Friday, November 21st, at 3:00 PM. Chairwoman Jeong-Eun Hyun of the Hyundai Group, President Kwang Hyung Lee of KAIST, and Director Jaeheung Han of the KAIST Space Science Research Institute attended the event to exchange expressions of mutual cooperation and gratitude.
Hyundai Group Chairwoman Jeong-Eun Hyun stated, "The late Chairman Mong-Hun Chung supported the development of the KAIST Satellite Research Center with his deep passion for science and space," and "I hope this environmental improvement project will carry on his legacy, contribute to the development of Korean space technology, and serve as an opportunity for more young talents to foster their dreams."
KAIST President Kwang Hyung Lee stated, "The Chung Mong-Hun Uri-Star Research Building is a symbolic space for the development of South Korea's space technology, and this environmental improvement project will serve as an opportunity to enhance both research efficiency and the value of public experience," adding, "The meaningful sponsorship from the Imdang Scholarship and Culture Foundation will be a great source of strength for KAIST's future space research development."
2025.11.21 View 2874