Candida
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KAIST Develops Novel Candidiasis Treatment Overcoming Side Effects and Resistance
<(From left) Ph. D Candidate Ju Yeon Chung, Prof.Hyun Jung Chung, Ph.D candidate Seungju Yang, Ph.D candidate Ayoung Park, Dr. Yoon-Kyoung Hong from Asan Medical Center, Prof. Yong Pil Chong, Dr. Eunhee Jeon>
Candida, a type of fungus, which can spread throughout the body via the bloodstream, leading to organ damage and sepsis. Recently, the incidence of candidiasis has surged due to the increase in immunosuppressive therapies, medical implants, and transplantation. Korean researchers have successfully developed a next-generation treatment that, unlike existing antifungals, selectively acts only on Candida, achieving both high therapeutic efficacy and low side effects simultaneously.
KAIST (President Kwang Hyung Lee) announced on the 8th that a research team led by Professor Hyun-Jung Chung of the Department of Biological Sciences, in collaboration with Professor Yong Pil Jeong's team at Asan Medical Center, developed a gene-based nanotherapy (FTNx) that simultaneously inhibits two key enzymes in the Candida cell wall.
Current antifungal drugs for Candida have low target selectivity, which can affect human cells. Furthermore, their therapeutic efficacy is gradually decreasing due to the emergence of new resistant strains. Especially for immunocompromised patients, the infection progresses rapidly and has a poor prognosis, making the development of new treatments to overcome the limitations of existing therapies urgent.
The developed treatment can be administered systemically, and by combining gene suppression technology with nanomaterial technology, it effectively overcomes the structural limitations of existing compound-based drugs and successfully achieves selective treatment against only Candida.
The research team created a gold nanoparticle-based complex loaded with short DNA fragments called antisense oligonucleotides (ASO), which simultaneously target two crucial enzymes—β-1,3-glucan synthase (FKS1) and chitin synthase (CHS3)—important for forming the cell wall of the Candida fungus.
By applying a surface coating technology that binds to a specific glycolipid structure (a structure combining sugar and fat) on the Candida cell wall, a targeted delivery device was implemented. This successfully achieved a precise targeting effect, ensuring the complex is not delivered to human cells at all but acts selectively only on Candida.
<Figure 1: Overview of antifungal therapy design and experimental approach>
This complex, after entering Candida cells, cleaves the mRNA produced by the FKS1 and CHS3 genes, thereby inhibiting translation and simultaneously blocking the synthesis of cell wall components β-1,3-glucan and chitin. As a result, the
Candida cell wall loses its structural stability and collapses, suppressing bacterial survival and proliferation.
In fact, experiments using a systemic candidiasis model in mice confirmed the therapeutic effect: a significant reduction in
Candida count in the organs, normalization of immune responses, and a notable increase in survival rates were observed in the treated group.
Professor Hyun-Jung Chung, who led the research, stated, "This study presents a method to overcome the issues of human toxicity and drug resistance spread with existing treatments, marking an important turning point by demonstrating the applicability of gene therapy for systemic infections". She added, "We plan to continue research on optimizing administration methods and verifying toxicity for future clinical application."
This research involved Ju Yeon Chung and Yoon-Kyoung Hong as co-first authors , and was published in the international journal 'Nature Communications' on July 1st.
Paper Title: Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis
DOI: 10.1038/s41467-025-60684-7
This research was supported by the Ministry of Health and Welfare and the National Research Foundation of Korea.
2025.07.08 View 111 -
Repurposed Drugs Present New Strategy for Treating COVID-19
Virtual screening of 6,218 drugs and cell-based assays identifies best therapeutic medication candidates
A joint research group from KAIST and Institut Pasteur Korea has identified repurposed drugs for COVID-19 treatment through virtual screening and cell-based assays. The research team suggested the strategy for virtual screening with greatly reduced false positives by incorporating pre-docking filtering based on shape similarity and post-docking filtering based on interaction similarity. This strategy will help develop therapeutic medications for COVID-19 and other antiviral diseases more rapidly. This study was reported at the Proceedings of the National Academy of Sciences of the United States of America (PNAS).
Researchers screened 6,218 drugs from a collection of FDA-approved drugs or those under clinical trial and identified 38 potential repurposed drugs for COVID-19 with this strategy. Among them, seven compounds inhibited SARS-CoV-2 replication in Vero cells. Three of these drugs, emodin, omipalisib, and tipifarnib, showed anti-SARS-CoV-2 activity in human lung cells, Calu-3.
Drug repurposing is a practical strategy for developing antiviral drugs in a short period of time, especially during a global pandemic. In many instances, drug repurposing starts with the virtual screening of approved drugs. However, the actual hit rate of virtual screening is low and most of the predicted drug candidates are false positives.
The research group developed effective filtering algorithms before and after the docking simulations to improve the hit rates. In the pre-docking filtering process, compounds with similar shapes to the known active compounds for each target protein were selected and used for docking simulations. In the post-docking filtering process, the chemicals identified through their docking simulations were evaluated considering the docking energy and the similarity of the protein-ligand interactions with the known active compounds.
The experimental results showed that the virtual screening strategy reached a high hit rate of 18.4%, leading to the identification of seven potential drugs out of the 38 drugs initially selected.
“We plan to conduct further preclinical trials for optimizing drug concentrations as one of the three candidates didn’t resolve the toxicity issues in preclinical trials,” said Woo Dae Jang, one of the researchers from KAIST.
“The most important part of this research is that we developed a platform technology that can rapidly identify novel compounds for COVID-19 treatment. If we use this technology, we will be able to quickly respond to new infectious diseases as well as variants of the coronavirus,” said Distinguished Professor Sang Yup Lee.
This work was supported by the KAIST Mobile Clinic Module Project funded by the Ministry of Science and ICT (MSIT) and the National Research Foundation of Korea (NRF). The National Culture Collection for Pathogens in Korea provided the SARS-CoV-2 (NCCP43326).
-PublicationWoo Dae Jang, Sangeun Jeon, Seungtaek Kim, and Sang Yup Lee. Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay. Proc. Natl. Acad. Sci. U.S.A. (https://doi/org/10.1073/pnas.2024302118)
-ProfileDistinguished Professor Sang Yup LeeMetabolic &Biomolecular Engineering National Research Laboratoryhttp://mbel.kaist.ac.kr
Department of Chemical and Biomolecular EngineeringKAIST
2021.07.08 View 16539 -
Venture Startup by Middle School Students Makes Donation to KAIST
Korean middle school students who
participated in a venture program made donations to KAIST. “Mending”, a startup founded by Korean
middle school students, donated 10 million won and the education supplier “Edubox”
contributed 100 million won to the IP Education Center for Young Venture Candidates
at KAIST. The donations were made at the IP
Education Center’s 3rd graduation ceremony on February 14th
at KAIST. Mending was started by three students in
the IP Education Center in 2013. This startup
features volunteering through talent sharing and other educational endeavors. It
received voluntary donations from supporters of the programs. Hee-Yon Yon, the co-president of
Mending, said, “We have developed a new concept of business and showed profit
can be made through donations and sharing”. Edubox responded to the visions of
Mending and added to the donation for additional development of the IP
Education Center. The KAIST IP Education Center for
Young Venture Candidates was founded with the support of KIPO (Korean
Intellectual Property Office) and KIPA (Korea Invention Promotion Association)
in 2009. The curriculum consists of Intellectual Property, Entrepreneurship, Future
Technology and Humanities. Eighty students are selected for the program every
year and 200 students have successfully completed the program.
2014.02.18 View 8439 -
A graduate-level education for working professionals in science programs and exhibitions will be available from mid-August this year.
The Graduate School of Culture Technology (GSCT), KAIST, has created a new course for professionals who purse their career in science programs and exhibitions, which will start on August 19 and continue through the end of November 2010. The course will be held at Digital Media City in Seoul.
The course, also co-sponsored by National Science Museum, will offer students tuition-free opportunities to brush up their knowledge on the administration, policy, culture, technology, planning, contents development, and technology & design development, of science programs and exhibitions. Such subjects as science contents, interaction exhibitions, and utilization of new media will be studied and discussed during the course. Students will also have a class that is interactive, engaging, and visual, as well as provides hands-on learning activities.
A total of 30 candidates will be chosen for the course. Eligible applicants are graduates with a B.S. degree in the relevant filed, science program designers and exhibitors, curators for science and engineering museums, and policy planners for public and private science development programs.
2010.08.12 View 14848 -
S&T Policy Agenda of Major Presidential Candidates
Science and Technology Policy Agenda of Major Presidential Candidates
The KAIST TIMES recently reviewed science and technology policy suggestions made by five major presidential candidates. Below is a summary of the information assembled based on written interviews conducted by The KAIST TIMES, gatherings on science and technology policies, and press conferences.
Chung Dong-young of the United New Democratic Party
The UNDP’s Chung Dong-young presented a vision to join the world’s top seven aerospace leaders in an effort to transform Korea into a science-technology powerhouse.
In order to achieve this goal, he suggested five policy strategies: support research and development of creative, innovative science and technology, ; expand resources for the innovation of science and technology, ; promote academia and business partnerships, ; strengthen infrastructure to innovate scientific and technological fields, ; boost the morale of scientists and engineers, ; and promote the dissemination of scientific culture.
The most noticeable striking part element of his vision is to make add Korea to join the list of the world’s top seven aerospace powerhouses. Chung included the this vision in his 20 key 20 pledges, underscoring his commitment to the aerospace industry. He said that the aerospace industry can produce simultaneous growth of various high-tech industries.
Chung also vowed that he would extensively foster high-value added assembly industry in conjunction with a scheme to nurture parts and material industries.
As detailed action plans to achieve his vision, he cited development of small and medium-sized aircraft carriers and upgrading air control systems as part of the efforts to make Korea as a stronghold of popular aviation of in Northeast Asia. He also revealed plans to embark on a project to explore the Moon and send an unmanned probe there by 2020.
To implement aerospace development plans systematically, he suggested inaugurating the envisioned Korean Aeronautics and Space Administration, modeled after the NASA of the United States and JAXA of Japan.
Lee Myung-bak of the National Grand Party
Presidential candidate Lee pointed out basic sciences and open-source technologies as crucial prerequisites to achieve economic growth. As five implementation strategies to promote the development of these areas, he called for the fostering of more scientific and technological talents; a drastic increase in investment in science and technology; creation of new fusion industries that will serve as future growth engines; promotion of autonomy and creativity; and popularization of science and technology.
He also pledged to carry out two large-scale projects, the creation of “an international scientific-corporate city belt” and the technological development of new renewable energy.
Among them, drawing the largest attention is the creation of an “international scientific-corporate city belt” connecting several technological complexes located in Chungcheong Provinces. The city belt is envisioned to connect the Daedok Innopolis in Daejeon, the proposed Bio-Health Science Technopolis in Osong, Sceintific Industrial Complex in Ochang, and the new administrative town under construction in Yeongi-Gongju. At a lecture hosted by the Science and Technology Forum and the Korean Engineers Club, Lee said that the project has been motivated by the idea of locating research and corporate complexes in close proximity to bring about maximum efficiency of commercializing research results.
Kwon Young-ghil of the Democratic Labor Party
In a written interview with The KAIST TIMES, Kwon summed up his vision for science and technology as shifting from “science-technology for the rich and privileged” to “science and technology to promote public interest and participation.”
As action plans to realize his vision, he suggested increasing investment into public-interest research and development projects and building the necessary infrastructure as well as boosting relevance between science-technology policies and various welfare sectors including environment, health, and medicare. He also wishes to pay greater attention to improving the treatment of young engineers and scientists.
Moon Kook-hyun of the Creative Korea Party
Moon Kook-hyun’s science and technology policy proposals focus on nurturing more experts in the fields of science and technology. As specific action plans to ease the tendency among high-school graduates to shun the fields engineering and science as their majors, he revealed a plan to appoint a Prime Minister with an engineering or scientific background and positively expand social participation of engineering or science graduates.
He also expressed strong commitment to making Korea a technological power house, focusing on convergence of various high-tech industries including BT and IT. He would also build infrastructure to increase cooperation for technological development among large and mid and small-sized companies, and among Korea and many other countries.
Independent Candidate Lee Hoi-chang
Lee Hoi-chang’s vision for science and technology can be highlighted by his strong commitment to greatly increasing R& D investment in this area. He said that the move is aimed at expanding science and technology capital, which will serve as a fundamental infrastructure for corporate activities.
In particular, he said that he would concentrate on fostering eight core technologies based on individual knowledge and creativity: IT, BT, NT, ST, ET (Environment Technology), CT, MT(Marine Technology), and FT (Fusion Technology).
2007.12.17 View 18564
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Information on Notification of Student Numbers and Input of Personnel Information for Successful Candidates of the 2nd round of Undergraduate Student Collection
Information on Notification of Student Numbers and Input of Personnel Information for Successful Candidates of the 2nd round of Undergraduate Student Collection 2007
Successful candidates are asked to input their own personnel information by February 4 (Sun), 2007.
(Information can be input on holidays)
▶▶▶ Click here to see student numbers
▶▶▶ Click here to input personnel information
2007.01.26 View 12560
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List of successful candidates of the documentary examination for the second round of student collection for undergraduate courses 2007
List of successful candidates of the documentary examination for the second round of student collection for undergraduate courses 2007
List of successful candidates
※ Matters to be attended to
- Interviewees are asked to be with basic interview data (attached file), admission ticket for examination, and writing instruments.
- Please, admit basic interview data to interviewers directly at interview.
- Please, use the data attached to this information as basic interview data.
- Interviewees are asked to come to Classroom No. 304 of Creative Learning Building (E11).
2007.01.15 View 12253
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Nobel Laureate Applies for KAIST President
Korea Times / 2004.5.17By Kim Tae-gyu / Staff Reporter
A Nobel laureate has applied to become president of the Korea Advanced Institute of Science and Technology (KAIST), with the final decision scheduled for late this month.
The state-financed institute said on Sunday Robert Laughlin had thrown in his hat for the candidacy of the 15th president, along with a couple of Korean competitors.
Laughlin, who was born in California in 1950, made his name after being co-awarded the 1998 Nobel Prize in Physics with Horst Stoermer and Daniel Tsui for the discovery of a new form of quantum fluid.
The findings, which explained the fractional quantum hall effect for the first time, have been recognized as a significant breakthrough in the understanding of quantum physics.
The American physicist had maintained a special connection with Korea even before he received the prestigious prize and has visited Korea several times.
Early last month, he was appointed to head the Asia Pacific Center for Theoretical Physics (APCTP), the international research institute headquartered inside Pohang University of Science and Technology in North Kyongsang Province.
According to a KAIST official, Laughlin said during his latest visit to Korea this month that he would develop the KAIST as a research-oriented model and would limit involvement in management to encourage scientists to focus on creating value.
The KAIST board will select the next president May 28. Among other candidates are KAIST professors Shin Seong-cheol and Park Seong-ju.
voc200@koreatimes.co.kr
2004.05.21 View 16873