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Longevity mediated by suppressing age-associated circRNA
< (Back row from left) Prof. Yoon Ki Kim, Prof. Seung-Jae V. Lee, and Gwangrog Lee; (Front row from left) Dr. Sung Ho Boo, Sieun S. Kim, Seokjin Ham, and (top) Donghun Lee >
Cells in our bodies produce RNA based on genetic information stored in DNA, and RNA serves as a blueprint for making proteins. Researchers at our university have discovered a new phenomenon: removing 'circular RNA' that accumulates in cells as we age can slow down aging and extend lifespan. This study provides crucial clues for uncovering the principles of aging and developing treatment strategies for related diseases.
Professor Seung-Jae V. Lee’s research team (RNA-Mediated Healthspan and Longevity Research Center) from the Department of Biological Sciences, in collaboration with research teams led by Professors Yoon Ki Kim and Gwangrog Lee, announced on the 18th that they discovered the RNASEK protein—an enzyme that degrades circular RNA—plays a vital role in slowing aging and extending lifespan.
Until now, circular RNA has been regarded mainly as an aging marker because of its stability, which allows it to accumulate over time. However, the molecular mechanism for removing this RNA and its direct link to aging had not been clearly identified. The research team conducted this study to determine how the accumulation of circular RNA affects aging and whether an intracellular management system exists to regulate it.
Using Caenorhabditis elegans (C. elegans), a short-lived roundworm widely used in aging research, the team first confirmed that the circular RNA-degrading enzyme RNASEK is essential for longevity. They also discovered that as aging progresses, the amount of RNASEK decreases, resulting in an abnormal accumulation of circular RNA within cells.
Conversely, artificially increasing the levels of RNASEK (overexpression) extended the lifespan and allowed the organisms to survive longer in a healthy state. This implies that the process of appropriately removing cellular circular RNA is critical for maintaining health and longevity.
The research team also found that RNASEK prevents the toxic aggregation of circular RNAs in aged organisms. . When RNASEK is deficient and circular RNA accumulates, "stress granules" form abnormally inside the cell, which can impair cellular functions and accelerate aging.
RNASEK works alongside the chaperone protein HSP90 (which helps proteins avoid misfolding or clumping) to inhibit the formation of these stress granules and help cells maintain a normal state. Notably, this phenomenon was observed not only in C. elegans but also in human cells. In mammals, RNASEK also functions to directly degrade circular RNA; a deficiency of RNASEK in human cells and mouse models led to premature aging.
< Diagram showing progress toward longevity or aging depending on circular RNA and the removal enzyme RNASEK >
The researchers explained that this study is significant as it identifies a mechanism for regulating aging at the RNA level. They suggested that research using RNASEK to control circular RNA could lead to the development of treatment strategies for human aging and degenerative diseases.
Professor Seung-Jae V. Lee of KAIST, who led the study, explained, "Until now, circular RNA was merely regarded as a marker of aging that accumulates over time due to its stability. This study proves that circular RNA accumulated during aging actually induces aging, and that RNASEK, which removes it, is a key regulator that slows aging and induces healthy longevity."
< (AI-generated image) Longevity induced by the circular RNA-removing enzyme RNASEK >
Drs. Sieun S. Kim, Seokjin Ham, Sung Ho Boo, and Donghun Lee from the KAIST Department of Biological Sciences participated as joint first authors. The research results were published on February 24 in the world-renowned scientific journal Molecular Cell.
Paper Title: Ribonuclease $\kappa$ promotes longevity by preventing age-associated accumulation of circular RNA in stress granules
DOI: 10.1016/j.molcel.2026.01.031
This research was conducted with support from the Leader Researcher Program of the National Research Foundation of Korea.
2026.03.18 View 1871 -
Professor Jihyeon Yeom Selected as Early Career Advisory Board Member for Top Chemistry and Materials Journal
< Professor Jihyeon Yeom >
KAIST announced on the 13th that Professor Jihyeon Yeom from the Department of Materials Science and Engineering has been selected as a member of the Early Career Advisory Board (ECAB) for Chemical Reviews, widely considered the world's most prestigious academic journal in the field of chemistry.
Published by the American Chemical Society (ACS), Chemical Reviews is a flagship review journal that comprehensively organizes and surveys the most influential research achievements across all areas of chemistry and materials science. It is evaluated as a top-tier international journal in the field.
The journal boasts an Impact Factor (IF) of 56, ranking it among the highest of all scientific journals worldwide. Its authority is particularly significant because it is a review journal that analyzes global research trends to suggest future academic directions, rather than simply publishing individual experimental data.
The ECAB, which began its term in January 2026, consists of 10 researchers selected from among rising global science leaders. Candidates are evaluated based on academic originality, research impact, and contributions to the scientific community. Members provide advisory roles for the journal's academic direction and strategic planning, contributing to the discovery of next-generation research trends and the expansion of global research networks.
This selection highlights that Professor Yeom’s research achievements are receiving high international acclaim.
Professor Yeom is conducting research on applying "chirality"—a property where objects, like DNA or proteins, are mirror images of each other but cannot be perfectly superimposed—to nanomaterials. Her core work involves precisely controlling atomic arrangements to realize artificial materials that can interact naturally with biological signals.
In particular, she is gaining attention for developing next-generation smart healthcare technology that combines light-responsive chiral materials with Artificial Intelligence (AI) to detect and analyze minute changes in the human body in real time. Professor Yeom explained that these chiral characteristics offer new possibilities for expanding information transmission and processing capabilities beyond simple structural properties.
Building on this foundation, she plans to expand her research into various fields, including precision medical diagnostic technology, next-generation optoelectronic devices utilizing circularly polarized light, and AI-based platforms.
Professor Yeom has established herself as a global leader in chiral materials research, recently publishing results in world-renowned journals such as Nature Communications, Advanced Materials, ACS Nano, and Accounts of Chemical Research.
"Chirality is not just a structural characteristic, but a new degree of freedom that expands the functional and information-processing capabilities of matter," said Professor Yeom. "I plan to expand my research into chiral-based electronic and optical devices, bio-diagnostic technologies, and AI-based spectroscopic platforms in the future."
This ECAB selection once again demonstrates the research competitiveness and international standing of the KAIST Department of Materials Science and Engineering. It is expected to further strengthen KAIST's role as a global research hub in the field of next-generation materials research.
2026.03.13 View 1293 -
KAIST NYU Host AI Governance Summit in New York
< KAIST Professor Kyung Ryul Park delivering a keynote speech >
KAIST announced on February 9th that the KAIST-NYU AI and Digital Governance Summit, co-hosted with New York University (NYU), was held at NYU in New York from February 6 to 7 (local time). Amid the rapidly expanding impact of Artificial Intelligence (AI) across society, this summit was designed to combine private consensus meetings with public discussions to seek practical AI governance solutions that harmonize technological innovation with safety and ethical responsibility.
The summit was attended by 60 global AI governance leaders representing academia, industry, and civil society, including NYU professors Matthew Liao and David Chalmers, Victoria Nash (Director of the Oxford Internet Institute), Professor Vincent Conitzer (Carnegie Mellon University), Iason Gabriel (Principal Scientist at Google DeepMind), and Philip Goldberg (former U.S. Ambassador to South Korea). In particular, the public discussion on the second day drew high interest, with approximately 450 audience members in attendance.
< Brad Carson, U.S. Representative for Responsible Innovation and former U.S. Congressman, delivering a keynote speech >
This event garnered attention as an 'experimental consensus model' aimed at deriving an actionable AI governance framework beyond a simple forum. KAIST’s Global Center for Open Development with Evidence-based Strategies (G-CODEs) and the NYU Center for Bioethics had formed three working groups—Governance Requirements, Institutional Architecture, and Implementation Pathways—since last December to conduct preliminary discussions. At the New York site, practice-oriented recommendations were derived through intensive consensus-style discussions and voting.
In the Governance Requirements session, the need for enhanced oversight and monitoring of high-risk AI systems was discussed. In the ‘Institutional Architecture’ session, principles for designing AI oversight bodies were reviewed, referencing existing high-risk technology oversight models such as the FDA, IRB, and FAA. In the Implementation Pathways session, short-term governance tools and corporate responsibility standards that could be applied even during the current gap in international regulation were addressed as key issues.
Major global Big Tech experts from Meta, Google DeepMind, IBM, Amazon, Anthropic, TikTok and Hugging Face participated in the summit. From KAIST, researchers including Prof. So Young Kim , Prof. Kyung Ryul Park, and Prof. Hyungjun Kim shared Korea’s research achievements in AI governance.his event was conducted with support from the Korea Foundation’s (KF) international collaborative research program.
Professor Kyung Ryul Park of KAIST stated, “This summit was a meaningful attempt to expand AI governance beyond technical regulation into a matter of international cooperation and institutional design. Through the cooperation between KAIST and NYU, we will build a foundation for Korea to lead global AI governance discussions.”
KAIST President Kwang Hyung Lee remarked, “The importance of governance discussions for responsible AI innovation is growing. KAIST will continue to lead interdisciplinary research and policy discussions in the field of AI governance through international partnerships.”
< Sebastien Krier, AI Policy Lead at Google DeepMind, speaking >
2026.02.09 View 2153 -
KAIST Proposes a Multinational AI Cooperation Strategy Beyond U.S.–China Dominance
2026.01.19 View 2005 -
KAIST Suppresses Side Effects of mRNA Therapeutics, Broadly Applicable Platform for Safer, Personalized Treatments
<(From Left) Professor Yong Woong Jun, Ph.D candidate Tae Ung Jeong, Ph.D candidate Jihun Choi>
mRNA, widely known from the COVID-19 vaccine, is not actually a “therapeutic agent,” but a technology that delivers the blueprint for functional proteins into the body so that induces therapeutic effects. Recently, its application has expanded to cancer and genetic disease treatments, but mRNA therapeutics have caused serious side effects such as pulmonary embolism, stroke, thrombosis, and autoimmune diseases because proteins are excessively produced all at once immediately after administration. Although technology to control the endogenous protein factory has been continuously needed, there had been no suitable solution.
KAIST (President Kwang Hyung Lee) announced on the 1st of December that Professor Yong Woong Jun’s research team in the Department of Chemistry has proposed a new strategy that can control the initiation timing and rate at which mRNA produces proteins. By using this method, the rate of protein production can be adjusted/personalized according to a patient’s condition, enabling safer treatment.
This technology is expected to serve as an important turning point in next-generation mRNA therapeutics, not only fundamentally reducing side effects of mRNA treatments but also enabling application to treatment areas requiring precise protein regulation such as stroke, cancer, and immune diseases.
For a protein to be produced, the cell’s “protein production machinery (ribosomes and initiation factors)” must attach to the mRNA blueprint and begin working. The research team focused on the fact that delaying this process even slightly can prevent the sudden surge of protein production.
Therefore, instead of using complex technologies, they developed a simple method in which intentionally slightly damaged DNA fragments are attached to mRNA. These DNA fragments act like a small “shield,” preventing the protein production machinery from immediately attaching to the mRNA and thereby gently slowing the initiation speed of protein production.
The damaged DNA used here is a safe biological material naturally recycled in the body and is very inexpensive. Because it only needs to be mixed with mRNA right before injection, it is suitable for real-world medical use.
As time passes, the body’s natural “repair enzymes” partially degrade the damaged DNA, and during this process, the structure attached to the mRNA is released, smoothly transitioning the protein production speed back to normal mode. As a result, the previous risk of proteins being explosively produced all at once is greatly reduced.
The research team confirmed that by adjusting the length and degree of damage of the DNA, they could precisely design when and how slowly protein production would begin. They also found that even when multiple types of mRNA are administered at once, the proteins can be produced sequentially in the desired order, meaning this method could innovate existing approaches that required multiple separate injections for complex treatments.
This technology was selected by KAIST as one of its “Future Promising Core Technologies” and was also introduced at the “2025 KAIST Techfair Technology Transfer Session.”
<A translation-control strategy based on DNA–mRNA hybrids. The damaged base (in red) is removed by a repair enzyme, after which the DNA and mRNA dissociate, allowing translation factors and ribosomes to bind and initiate protein translation>
Professor Yong Woong Jun said, “Biological phenomena are ultimately chemistry, so we were able to precisely control the protein production process through a chemical approach,” and added that “this technology not only enhances the safety of mRNA therapeutics but also provides a foundation for expanding into precision treatments tailored to various diseases such as cancer and genetic disorders.”
The results of this research, with Jihun Choi (KAIST, 3rd-year PhD student) and Tae Ung Jeong (KAIST, 1st-year PhD student) participating as co–first authors, were published on November 6 in Angewandte Chemie International Edition, one of the most prestigious journals in the field of chemistry.
※ Paper title: “Harnessing Deaminated DNA to Modulate mRNA Translation for Controlled and Sequential Protein Expression,” Authors: Jihun Choi (KAIST, co–first author), Tae Ung Jeong (KAIST, co–first author), and Yong Woong Jun (KAIST, corresponding author), among a total of 10 authors, DOI: 10.1002/anie.202516389
This study was supported by the National Research Foundation of Korea (NRF) through the Excellent Young Researcher Program.
2025.12.02 View 2361 -
Professor Sang Yup Lee Selected as IETI 'Laureate Distinguished Fellow'
<Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering>
Professor Sang Yup Lee of KAIST Department of Chemical and Biomolecular Engineering has been selected as a 'Laureate Distinguished Fellow,' the highest rank of fellow, by the International Engineering and Technology Institute (IETI).
Professor Lee is a globally renowned biotechnologist who has been leading research on the sustainable production of bio-based chemicals, and he received the 'ENI Award' in 2018. With this selection, he stands shoulder-to-shoulder with the world's top scholars, including recipients of the Nobel, Fields, and Turing Prizes.
IETI is an international academic organization established in Hong Kong in 2015 to promote innovation and international cooperation in the fields of engineering, technology, and science. Each year, the institute selects researchers with significant academic influence worldwide and appoints them into three grades: Laureate Distinguished Fellow, Distinguished Fellow, and Fellow. Professor Lee has been named to the most prestigious grade among these.
<IETI 2025 Fellow Selection Photo>
A total of 70 new fellows were selected in 2025. Among them, 14 individuals were named Laureate Distinguished Fellows, which includes recipients of top honors such as the Nobel, Fields, and Turing Prizes. Besides Professor Lee, this group includes Dudley Herschbach of Harvard University (Nobel Prize in Chemistry), Vint Cerf of Google (Turing Award), and Shigefumi Mori of Kyoto University (Fields Medal).
IETI stated that the selection process involved a rigorous five-step procedure: nomination, qualification review, document screening, expert voting, and final evaluation. It also expressed hope that the newly appointed fellows will demonstrate academic leadership in their respective research fields and contribute to global scientific and technological innovation and the promotion of international cooperation.
2025.11.10 View 2398 -
AI Nüshu Wins International Award
< (From left) Dr. Yuqian Sun, Professor Chang-Hee Lee of the Department of Industrial Design, and Ali Asadipour, Director of CSRC at the Royal College of Art >
'Nüshu (女書)' is the world's only women's script, a unique writing system created autonomously by women in Hunan Province, China, starting around the 19th century. These women, excluded from Hanzi education, used it to record their lives and communicate with each other. A research team from KAIST participated in the 'AI Nüshu (女书)' project, which combines the script's significance (creation amidst oppression, female solidarity, linguistic experimentation) with modern technology, winning a prestigious international award often called the 'Academy Award of the media art world.'
KAIST announced on the 10th that the 'AI Nüshu' project, jointly conducted by Professor Chang-Hee Lee's research team from the Department of Industrial Design and Ali Asadipour, Director of the Computer Science Research Center at the Royal College of Art (RCA), was selected for the Honorary Mention in the Digital Humanity category at the 'Prix Ars Electronica 2025,' the world's highest-level media art festival.
< Installation image of 'AI Nüshu' >
The 'Prix Ars Electronica,' known as the 'Academy Award of the media art world,' is the premier international media art competition held annually in Linz, Austria. This competition, which discovers innovative works spanning the boundaries of art and science, saw 3,987 submissions from 98 countries this year, with only two works receiving the honor in the Digital Humanity category.
The award-winning work, 'AI Nüshu (女书),' is based on 'Nüshu,' the world's only women's script created by Chinese women who were excluded from literacy education to record and communicate their lives.
The KAIST research team and collaborators combined this script with Computational Linguistics to create an installation that visitors can directly experience.
The artificial intelligence within the artwork learns the communication methods of pre-modern Chinese women and generates its own new language. This is regarded as a symbol of resistance against the patriarchal order and a feminist endeavor that moves beyond Western-centric views on language.
< Example of the same sentence expressed in English, Chinese, Nüshu, and AI Nüshu >
It also received high praise for artistically presenting the possibility of machines creating new languages, going beyond the preconception that 'only humans create language.'
Dr. Yuqian Sun of the Royal College of Art expressed her feelings, saying, "Although there were many difficulties in my life and research process, I feel great reward and emotion through this award."
Professor Chang-Hee Lee of the KAIST Department of Industrial Design stated, "It is very meaningful that this contemplative art, born from the intersection of history, humanities, art, and technology, has led to such a globally prestigious award."
Detailed information about the project can be found on the official Prix Ars Electronica website (https://ars.electronica.art/prix/en/digitalhumanity/).
2025.10.13 View 4505 -
MICCAI 2025 Eve KAIST Day Successfully Held
< Scene of the KAIST Day Symposium Lectures >
KAIST announced on the September 23rd that the 'KAIST Day' special symposium, held on the eve of 'MICCAI 2025' at the Jeong Geun-mo Conference Hall of the KAIST Academic and Cultural Center on September 22, was successfully held with the attendance of more than 30 overseas scholars and 200 domestic researchers and students.
This event was a special program prepared to commemorate the hosting of MICCAI 2025 (The 28th International Conference on Medical Image Computing and Computer Assisted Intervention, Conference Chair: Professor Jina Park of KAIST School of Computing), the world's largest medical imaging conference. It was sponsored by the KAIST College of Engineering and Daejeon City, and was held under the theme of "From Insight to Intervention: Intelligent Imaging in Biomedicine."
KAIST and world-class scholars gathered to share the latest research results combining medical imaging and artificial intelligence, and to have an in-depth discussion on the future direction of next-generation medical technology, encompassing diagnosis and treatment.
Seven world-renowned scholars from the Americas, Europe, and Asia introduced their latest research, and about 30 overseas scholars toured KAIST's advanced medical imaging infrastructure and sought possibilities for collaboration by interacting with domestic researchers. In addition, attending domestic researchers and students had the opportunity for collaboration and international joint research through a networking session.
< A group photo from KAIST Day with President Kwang Hyung Lee and Conference Chair Jina Park >
This event provided an opportunity for domestic researchers to meet world-class scholars ahead of the opening of MICCAI 2025 and served as a starting point and symbolic place for KAIST and Daejeon City to foster Korea as a global hub for medical AI research. The event was planned and moderated by Professor Seungryong Cho and Associate Vice President Hyunju Lee, and was composed of four sessions. First, Professor Hyunwook Park introduced the history and development of medical imaging research at KAIST. Following this, in the "AI for Diagnosis & Disease Understanding" session, Professors Anne Martel, Kenji Suzuki, Hayit Greenspan, and Dimitris Metaxas presented their latest research on AI-based medical imaging, including cancer diagnosis, early detection, rare disease analysis, and multi-modal fusion.
In the next "Imaging Intelligence for Intervention" session, Professors Nasir Navab, Yongkwan Park, James Ji, Leo Joskowicz, and Hyunmin Bae shared clinical application cases such as AR/VR surgical assistance, ultra-high-resolution imaging, atlas-based analysis, surgical planning support, and personalized treatment with neuroimaging.
Each presentation demonstrated the possibilities of future medical imaging expanding beyond diagnosis to treatment and personalized medicine, and active exchanges continued through discussions and Q&A. After the lectures, overseas researchers toured KAIST's advanced infrastructure and conducted in-depth discussions with domestic researchers.
In addition, with the support of NVIDIA, the "NVIDIA Isaac for Healthcare Hands-on Lab" was held, allowing researchers and students to directly experience the latest AI medical platform.
< Invited speakers and attendees of the symposium >
Professor Jina Park of the KAIST School of Computing and Conference Chair of MICCAI 2025 said, "MICCAI is the world's top-level medical AI conference with a focus on clinical application. We organized this event to introduce KAIST's challenging research to the international community and to create new synergy through academic exchange. We expect MICCAI 2025, which will be held from the 23rd to the 27th at the Daejeon Convention Center, to become a representative international academic event for Daejeon, with more than 3,200 people registered."
KAIST President Kwang Hyung Lee said, "The hosting of MICCAI 2025 is an achievement that shows the international status of Korean science and technology. In particular, this pre-conference symposium held at KAIST was a meaningful event where world-class scholars gathered to discuss the future of medical imaging and AI, and it was an opportunity to once again confirm KAIST's status. KAIST will continue to take the lead in research and education that contributes to the promotion of human health by expanding global cooperation."
※ MICCAI 2025 Website: https://conferences.miccai.org/2025/en/
2025.09.23 View 2679 -
Semiconductor Leadership Spotlighted in Nature Sister Journal
<(From Left) Prof. Shinhyun Choi, Prof. Young Gyu Yoon, Prof.Seunghyub Yoo from the School of Electrical Engineering, Prof. Kyung Min Kim from Materials Science and Engineering>
KAIST (President Kwang Hyung Lee) announced on the 5th of September that its semiconductor research and education achievements were highlighted on August 18 in Nature Reviews Electrical Engineering, a sister journal of the world-renowned scientific journal Nature.
Title: Semiconductor-related research and education at KAIST DOI: 10.1038/s44287-025-00204-3
This special "Focus" article provides a detailed look at KAIST's leadership in next-generation semiconductor research, talent development, and global industry-academia collaboration, presenting a future blueprint for Korea's semiconductor industry. Editor Silvia Conti personally conducted the interviews, with KAIST professors including Kyung Min Kim from the Department of Materials Science and Engineering, and Young Gyu Yoon, Shinhyun Choi, Sung-Yool Choi, and Seunghyub Yoo from the School of Electrical Engineering, participating.
KAIST operates educational programs such as the School of Electrical Engineering, the Department of Semiconductor Systems Engineering, and the Graduate School of Semiconductor Engineering. It is leading next-generation semiconductor research in areas like neuromorphic computing, in-memory computing, and 2D new material-based devices. Building on this foundation, researchers are developing new architectures and devices that transcend the limitations of existing silicon, driving innovation in various application fields such as artificial intelligence, robotics, and medicine.
Notably, research on implementing biological functions like synapses and neurons into hardware platforms using new types of memory such as RRAM and PRAM is gaining international attention. This work opens up possibilities for applications in robots, edge computing, and on-sensor AI systems.
Furthermore, KAIST has operated EPSS (Samsung Advanced Human Resources Training Program) and KEPSI (SK Hynix Semiconductor Advanced Human Resources Training Program) based on long-standing partnerships with Samsung Electronics and SK Hynix. Graduate students in these programs receive full scholarships and are guaranteed employment after graduation. The Department of Semiconductor Systems Engineering, newly established in 2022, selects 100 undergraduate students each year to provide systematic education. Additionally, the KAIST–Samsung Electronics Industry-Academia Cooperation Center, which involves more than 70 labs annually, serves as a long-term hub for joint industry-academia research, contributing to solving critical issues within the industry.
The article emphasizes KAIST's growth beyond a simple research institution into an international research hub. KAIST is enhancing diversity and inclusivity by expanding the hiring of female faculty and establishing a Global Talent Visa Center to support foreign professors and students, attracting outstanding talent from around the world. As a core university within the Daedeok Research Complex (Daedeok Innopolis), it serves as the heart of "Korea's Silicon Valley."
KAIST researchers predict that the future of semiconductor technology is not in simple device miniaturization but in a convergent approach involving neuromorphic technology, 3D packaging technology, and AI applications. This article shows that KAIST's strategic research direction and leadership are gaining attention from both the global academic and industrial communities.
Professor Kyung Min Kim stated, "I am very pleased that KAIST's next-generation semiconductor research and talent development strategy has been widely publicized to domestic and international academia and industry through this article, and we will continue to contribute to the development of future semiconductor technology with innovative convergence research."
KAIST President Kwang Hyung Lee remarked, "Being highlighted for our semiconductor research and education achievements in a world-renowned science journal is a testament to the dedication and pioneering spirit of our university members. I am delighted that KAIST's growth as a global research hub is gaining recognition, and we will continue to expand industry-academia collaboration to lead next-generation semiconductor innovation and play a key role in helping Korea become a future semiconductor powerhouse."
2025.09.05 View 5569 -
“Why are we depressed?” KAIST is identifying the cause of depression and uncovering clues for treatment
Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes* have still not been clearly identified. A domestic research team has discovered that depression may not simply be caused by neuronal damage, but can also arise from the dysregulation of specific neural signaling pathways. In particular, they identified the molecular reason why elderly patients with depression do not respond to conventional antidepressants. This study suggests the possibility of therapeutic approaches using optogenetic technology to regulate neural signaling, and it provides clues for the development of new treatment strategies targeting the protein ‘Numb’ protein for elderly patients with depression.
*Molecular causes: explanations for the origin of a disease at the level of molecules, proteins, or genes in the brain.
KAIST (President Kwang Hyung Lee) announced on the 19th of August that a research team led by Distinguished Professor Won Do Heo of the Department of Biological Sciences at KAIST, in collaboration with forensic pathologist Minju Lee of the National Forensic Service (Director Bong Woo Lee) and Professor Seokhwi Kim of the Department of Pathology at Ajou University Medical Center (Director Sangwook Han), identified a new molecular mechanism for depression through RNA sequencing and the immunohistochemical analysis of brain tissue from patients who had committed suicide. Furthermore, they demonstrated in animal models that antidepressant effects can be restored by regulating the signaling pathway that induces neural recovery using optogenetic technology.
The research team focused on the hippocampus, the brain region responsible for memory and emotion, and in particular on the dentate gyrus (DG). The DG is the entry point of information into the hippocampus, playing a role in new memory formation, neurogenesis, and emotional regulation, and is closely linked with depression.
Using two representative mouse models for depression (the corticosterone stress model and the chronic unpredictable stress model), the team found that stress induced a striking increase in the signaling receptor FGFR1 (Fibroblast Growth Factor Receptor 1) in the DG. FGFR1 receives growth factor (FGF) signals and transmits growth and differentiation commands within cells.
Subsequently, using conditional knockout (cKO) mice in which the FGFR1 gene was deleted, the researchers revealed that the absence of FGFR1 made mice more vulnerable to stress and led them to exhibit depressive symptoms more quickly. This indicates that FGFR1 plays a critical role in proper neural regulation and stress resistance.
The team then developed an ‘optoFGFR1 system’ using optogenetics, enabling FGFR1 —essential for stress resistance—to be activated by light. They observed that activating FGFR1 in depression mouse models lacking FGFR1 restored antidepressant effects. In other words, they experimentally demonstrated that the activation of FGFR1 signaling alone could improve depressive behavior.
Surprisingly, however, in aged depression mouse models, the activation of FGFR1 signaling through the optoFGFR1 system did not yield antidepressant effects. Investigating further, the researchers found that in the aged brains, a protein called ‘Numb’ was excessively expressed and interfered with FGFR1 signaling.
Indeed, analysis of postmortem human brain tissue also showed the specific overexpression of Numb protein only in elderly patients with depression. When the researchers suppressed Numb using a gene regulatory tool (shRNA) while simultaneously activating FGFR1 signaling in mouse models, neurogenesis and behavior—previously unrecoverable—returned to normal even in aged depression models. This shows that the Numb protein acts as a “blocker” of FGFR1 signaling and is a key factor preventing the hippocampus from executing antidepressant mechanisms.
Distinguished Professor Won Do Heo of KAIST said, “This study is meaningful in that it revealed that depression may not only result from simple neuronal damage, but can also arise from the dysregulation of specific neural signaling pathways. In particular, we identified the molecular reason why antidepressants are less effective in elderly patients, and we expect this to provide a clue for the development of new therapeutic strategies targeting the Numb protein.”
He added, “Moreover, this interdisciplinary study, which combined KAIST’s expertise in neuroscience with the National Forensic Service’s forensic brain analysis technologies, is expected to serve as a bridge between basic research on psychiatric disorders and clinical applications.”
This study, led by first author Jongpil Shin, a PhD student in the Department of Biological Sciences at KAIST, was published on August 15, 2025, in the international journal Experimental & Molecular Medicine.
Paper title: “Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorder”
DOI: https://doi.org/10.1038/s12276-025-01519-9
This research was supported by the Ministry of Science and ICT’s National Research Foundation of Korea through the ASTRA program and the Bio-Medical Technology Development project.
2025.08.19 View 3662 -
KAIST Identifies Key to Slowing Aging via RNA Regulation... Unlocks Mechanism for Longevity
As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases. However, the connection between aging and RNA has remained largely unexplored. Now, a Korean research team has discovered that a ribosome-associated quality control factor—PELOTA, a protein essential for eliminating abnormal mRNA—plays a central role in slowing aging and promoting longevity. This breakthrough is expected to provide a new direction for future therapeutic strategies targeting human aging and neurodegenerative diseases.
KAIST (President Kwang Hyung Lee) announced that a joint research team—led by Professor Seung-Jae V. Lee of the Department of Biological Sciences at KAIST and the Research Center for RNA-mediated Healthy Longevity, Professor Jinsoo Seo of Yonsei University (President Dong-Sup Yoon), and Professor Kwang-Pyo Lee of the Korea Research Institute of Bioscience and Biotechnology (KRIBB, President Suk Yoon Kwon) under the National Research Council of Science & Technology (NST, Chairman Yeung-Shik Kim—has discovered that the protein ‘PELOTA*’, which plays a key role in ribosome-associated quality control, regulates the pace of aging.
*PELOTA: A key protein in maintaining cellular translational homeostasis, responsible for detecting and resolving errors during mRNA translation by ribosomes.
Until now, RNA—particularly mRNA—has generally been regarded as a transient intermediary in protein synthesis. Its instability made it difficult to study quantitatively or track over time, leaving its physiological and functional roles relatively understudied compared to DNA.
Using C. elegans (a nematode widely used in aging research due to its short lifespan), the researchers first discovered that the ribosome-associated quality control factor PELOTA is essential for longevity. In particular, when PELOTA was overexpressed in normal nematodes, their lifespan was extended, suggesting that ribosome-associated quality control mechanisms involved in removing abnormal mRNA are necessary for promoting longevity.
The study also revealed that the ribosome-associated quality control system simultaneously regulates both the mTOR signaling pathway—which senses nutrient status or growth signals to control cell growth, protein synthesis, and autophagy, and plays a key role in aging and energy metabolism—and the autophagy pathway, the cellular cleanup and recycling system through which cells break down and reuse unnecessary or damaged components.
When PELOTA was deficient, the mTOR pathway became abnormally activated, and autophagy was suppressed—accelerating aging. Conversely, activation of PELOTA inhibited mTOR and induced autophagy, thereby maintaining cellular homeostasis and extending lifespan.
Notably, this mechanism was found to be conserved in both mice and humans. The study also showed that the loss of PELOTA could contribute to muscle aging and Alzheimer’s disease, suggesting its relevance to age-related disorders.
These findings indicate that the study of PELOTA and ribosome-associated quality control could play an important role in developing therapeutic strategies for human aging and neurodegenerative diseases.
Professor Seung-Jae V. Lee of KAIST, who led the research, stated, “While the connection between quality control and aging has been well established at the DNA and protein levels, molecular evidence showing that RNA quality control also functionally contributes to lifespan regulation has been very limited.” He emphasized that the “study provides strong evidence that the removal of abnormal RNA is a central axis in the aging regulatory network.”
The study was published on August 5th in the prestigious journal PNAS (Proceedings of the National Academy of Sciences), with Dr. Jongsun Lee and Dr. Eun Ji Kim of KAIST, Dr. Bora Lee of KRIBB, and Dr. Hyein Lee of Yonsei University as co-first authors.
※ Title: Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species ※ DOI: https://doi.org/10.1073/pnas.2505217122
This research was supported by the Global Leader Research Project of the National Research Foundation of Korea.
2025.08.18 View 4804 -
KAIST Takes the Lead in Developing Core Technologies for Generative AI National R&D Project
KAIST announced on the 15th of August that Professor Sanghoo Park of the Department of Nuclear and Quantum Engineering has won two consecutive awards for early-career researchers at two of the world's most prestigious plasma academic conferences.
Professor Park was selected as a recipient of the Early Career Award (ECA) at the Gaseous Electronics Conference (GEC), hosted by the American Physical Society, on August 4. He was also honored with the Young Investigator Award, presented by the International Plasma Chemistry Society (IPCS), on June 19.
The American Physical Society's GEC Early Career Award is given to only one person worldwide every two years, based on a comprehensive evaluation of research excellence, academic influence, and contributions to the field of plasma. The award will be presented at GEC 2025, which will be held at COEX in Seoul from October 13 to 17.
Established in 1948, the GEC is a leading academic conference in the plasma field with a 77-year history of showcasing key research achievements in all areas of plasma, including physics, chemistry, diagnostics, and application technologies. Recently, advanced application research such as eco-friendly chemical processes, next-generation semiconductors, and atomic layer and ultra-low-temperature etching technology for HBM processes have been gaining attention.
To commemorate the award, Professor Park will give an invited lecture at GEC 2025 on the topic of "Deep-Learning-Based Spectroscopic Data Analysis for Advancing Plasma Spectroscopy." In his lecture, he will use case studies to demonstrate a method that allows even non-specialists to easily and quickly perform spectroscopic data analysis—which is essential for spectroscopy, a key analytical method in modern science including plasma diagnostics—by using deep learning technology.
Professor Park also won the Young Investigator Award from the IPCS at the 26th International Symposium on Plasma Chemistry (ISPC 26), which was held in Minneapolis, USA, from June 15 to 20.
First held in 1973, the ISPC (International Symposium on Plasma Chemistry) is a representative international conference in the field of plasma chemistry, held biennially. It covers a wide range of topics, from basic plasma chemical reaction principles to applications in semiconductor processes, green energy, environmental science, and biotechnology. Researchers from industry, academia, and research institutions worldwide share their latest findings at each event. The Young Investigator Award is given to a scientist who has obtained their doctorate within the last 10 years and has demonstrated outstanding achievements in the field.
Professor Park was recognized for his leading research achievements in using plasma-liquid interactions and real-time optical diagnostic technology to environmentally fix nitrogen from the air and precisely control the quantity and types of reactive chemical species that are beneficial to the human body and the environment.
Professor Sanghoo Park stated, "It is very meaningful to receive the Young Investigator Award representing Korea at the GEC event, which is being held in Korea for the first time in its history." He added, "I am happy that my consistent interest in and achievements in fundamental plasma science have been recognized, and it is even more significant that the efforts of the KAIST research team have been acknowledged by the world's top conferences."
2025.08.16 View 4061