Sukbok+Chang
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Distinguished Professor Sukbok Chang Named the 2022 Ho-Am Laureate
Distinguished Professor Sukbok Chang from the Department of Chemistry was named the awardee of the Ho-Am Prize in the fields of chemistry and life sciences. The award has recognized the most distinguished scholars, individuals, and organizations in physics and mathematics, chemistry and life sciences, engineering, medicine, arts, and community service in honor of the late founder of Samsung Group Byong-Chul Lee, whose penname is Ho-Am. The awards ceremony will be held on May 31 and awardees will receive 300 million KRW in prize money.
Professor Chang became the fourth KAIST Ho-Am laureate following Distinguished Professor Sang Yup Lee in engineering in 2014, Distinguished Professor Jun Ho Oh in engineering in 2016, and Distinguished Professor Gou Young Koh in medicine in 2018.
Professor Chang is a renowned chemist who has made pioneering research in the area of transition metal catalysis for organic transformations. Professor Chang is also one of the Highly Cited Researchers who rank in the top 1% of citations by field and publication year in the Web of Science citation index. He has made the list seven years in a row from 2016.
Professor Chang has developed a range of new and impactful C-H bond functionalization reactions. By using his approaches, value-added molecules can be readily produced from chemical feedstocks, representatively hydrocarbons and (hetero)arenes. His research team elucidated fundamental key mechanistic aspects in the course of the essential C-H bond activation process of unreactive starting materials. He was able to utilize the obtained mechanistic understanding for the subsequent catalyst design to develop more efficient and highly (stereo)selective catalytic reactions.
Among the numerous contributions he made, the design of new mechanistic approaches toward metal nitrenoid transfers are of especially high impact to the chemical community. Indeed, a series of important transition metal catalyst systems were developed by Professor Chang to enable the direct and selective C-H amidation of unreactive organic compounds, thereby producing aminated compounds that have important applicability in synthetic, medicinal, and materials science. He has also pioneered in the area of asymmetric C-H amination chemistry by creatively devising various types of chiral transition metal catalyst systems, and his team proved for the first time that chiral lactam compounds can be obtained at an excellent level of stereoselectivity.
Another significant contribution of Professor. Chang was the introduction of dioxazolones as a robust but highly reactive source of acyl nitrenoids for the catalytic C-H amidation reactions, and this reagent is now broadly utilized in synthetic chemistry worldwide.
Professor Chang also leads a research group in the Center for Catalytic Hydrocarbon Functionalizations at the Institute for Basic Science.
2022.04.06 View 7780 -
KAA Recognizes 4 Distinguished Alumni of the Year
The KAIST Alumni Association (KAA) recognized four distinguished alumni of the year during a ceremony on February 25 in Seoul. The four Distinguished Alumni Awardees are Distinguished Professor Sukbok Chang from the KAIST Department of Chemistry, Hyunshil Ahn, head of the AI Economy Institute and an editorial writer at The Korea Economic Daily, CEO Hwan-ho Sung of PSTech, and President Hark Kyu Park of Samsung Electronics.
Distinguished Professor Sukbok Chang who received his MS from the Department of Chemistry in 1985 has been a pioneer in the novel field of ‘carbon-hydrogen bond activation reactions’. He has significantly contributed to raising Korea’s international reputation in natural sciences and received the Kyungam Academic Award in 2013, the 14th Korea Science Award in 2015, the 1st Science and Technology Prize of Korea Toray in 2018, and the Best Scientist/Engineer Award Korea in 2019. Furthermore, he was named as a Highly Cited Researcher who ranked in the top 1% of citations by field and publication year in the Web of Science citation index for seven consecutive years from 2015 to 2021, demonstrating his leadership as a global scholar.
Hyunshil Ahn, a graduate of the School of Business and Technology Management with an MS in 1985 and a PhD in 1987, was appointed as the first head of the AI Economy Institute when The Korea Economic Daily was the first Korean media outlet to establish an AI economy lab. He has contributed to creating new roles for the press and media in the 4th industrial revolution, and added to the popularization of AI technology through regulation reform and consulting on industrial policies.
PSTech CEO Hwan-ho Sung is a graduate of the School of Electrical Engineering where he received an MS in 1988 and a PhD in EMBA in 2008. He has run the electronics company PSTech for over 20 years and successfully localized the production of power equipment, which previously depended on foreign technology. His development of the world’s first power equipment that can be applied to new industries including semiconductors and displays was recognized through this award.
Samsung Electronics President Hark Kyu Park graduated from the School of Business and Technology Management with an MS in 1986. He not only enhanced Korea’s national competitiveness by expanding the semiconductor industry, but also established contract-based semiconductor departments at Korean universities including KAIST, Sungkyunkwan University, Yonsei University, and Postech, and semiconductor track courses at KAIST, Sogang University, Seoul National University, and Postech to nurture professional talents. He also led the national semiconductor coexistence system by leading private sector-government-academia collaborations to strengthen competence in semiconductors, and continues to make unconditional investments in strong small businesses.
KAA President Chilhee Chung said, “Thanks to our alumni contributing at the highest levels of our society, the name of our alma mater shines brighter. As role models for our younger alumni, I hope greater honours will follow our awardees in the future.”
2022.03.03 View 7738 -
Three Professors Named to Highly Cited Researchers 2020 List
Distinguished Professor Sukbok Chang from the Department of Chemistry, Distinguished Professor Sang-Yup Lee from the Department of Chemical & Biomolecular Engineering, and Professor Jiyong Eom from the College of Business were named to Clarivate’s Highly Cited Researchers 2020 list.
Clarivate announced the researchers who rank in the top 1% of citations by field and publication year in the Web of Science citation index. A total of 6,167 researchers from more than 60 countries were listed this year and 37 Korean scholars made the list.
The methodology that determines the “Who’s Who” of influential researchers draws on data and analyses performed by bibliometric experts and data scientists at the Institute for Scientific Information at Clarivate. It also uses the tallies to identify the countries and research institutions where these scientific elite are based. More than 6,000 researchers from 21 fields in the sciences, social sciences, and cross field categories were selected based on the number of highly cited papers they produced over an 11-year period from January 2009 to December 2019.
Professor Chang made the list six years in a row, while Professor Lee made it for four consecutive years, and Professor Eom for the last two years. Professor Chang’s group (http://sbchang.kaist.ac.kr) investigates catalytic hydrocarbon functionalization. Professor Lee (http://mbel.kaist.ac.kr) is a pioneering scholar in the field of metabolic engineering, systems, and synthetic biology. Professor Eom’s (https://kaistceps.quv.kr) research extends to energy and environmental economics and management, energy big data, and green information systems.
2020.11.30 View 9671 -
Distinguished Professor Sukbok Chang Donates His Prize Money
The honoree of the 2019 Korea Best Scientist and Technologist Award, Distinguished Professor Sukbok Chang donated his prize money of one hundred million KRW to the Chemistry Department Scholarship Fund and the Lyu Keun-Chul Sports Complex Management Fund during a donation ceremony last week.
Professor Chang won the award last month in recognition of his pioneering achievements and lifetime contributions to the development of carbon-hydrogen activation strategies, especially for carbon-carbon, carbon-nitrogen, and carbon-oxygen formations. Professor Chang, a world renowned chemist, has been recognized for his highly selective catalytic systems, allowing the controlled defunctionalization of bio-derived platform substrates under mild conditions and opening a new avenue for the utilization of biomass-derived platform chemicals.
“All my achievements are the results of my students’ hard work and dedication. I feel very fortunate to have such talented team members. I want to express my sincere gratitude for such a great research environment that we have worked together in so far,” said Professor Chang at the ceremony.
KAIST President Sung-Chul Shin said, “Not only will Professor Chang’s donation make a significant contribution to the Department of Chemistry, but also to the improvement of the Lyu Keun-Chul Sports Complex’s management, which directly links to the health and welfare of the KAIST community.”
Professor Chang currently holds the position of distinguished professor at KAIST and director of the Center for Catalytic Hydrocarbon Functionalizations in the Institute for Basic Science (IBS). He previously received the Kyung-Ahm Academic Award in 2013 and the Korea Toray Science Award in 2018. All these prize money also went to the school.
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2019.08.26 View 8449 -
Two Alumni Win the Korea Best Scientist and Technologist Awards
Vice Chairman Ki-Nam Kim (Left) and Distinguished Professor Sukbok Chang (Right)
<ⓒ Photo by MSIT and KOFST>
Distinguished KAIST Professor Sukbok Chang from the Department of Chemistry and Vice Chairman Ki-Nam Kim of Samsung Electronics were selected as the winners of the “2019 Korea Best Scientist and Technologist Awards” by the Ministry of Science and ICT (MSIT) and the Korean Federation of Science and Technology Societies (KOFST). The awards, which were first handed out in 2003, are the highest honor bestowed to the two most outstanding scientists in Korea every year, and this year’s awardees are of greater significance as they are both KAIST alumni.
Professor Chang was recognized for his pioneering achievements and lifetime contributions to the development of carbon-hydrogen activation strategies, especially for carbon-carbon, carbon-nitrogen, and carbon-oxygen formations. His research group has also been actively involved in the development of highly selective catalytic systems allowing the controlled defunctionalization of bio-derived platform substrates under mild conditions, and opening a new avenue for the utilization of biomass-derived platform chemicals. The results of his study have been introduced worldwide through many prestigious journals including Science, Nature Chemistry, and Nature Catalysis, making him one of the world's top 1% researchers by the number of references made to his papers by his peers over four consecutive years from 2015 to 2018.
Vice Chairman Kim, who received his M.E. degree from KAIST’s School of Electrical Engineering in 1983, has been credited with playing a leading role in the development of system semiconductors.
The awards were conferred on July 4 at the opening ceremony of the 2019 Korea Science and Technology Annual Meeting.
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2019.07.09 View 12337 -
New Catalyst for Synthesizing Chiral Molecules Selectively
(from left: Dr. Yoonsu Park and Professor Sukbok Chang from the Department of Chemistry)
Molecules in nature often have “twin” molecules that look identical. In particular, the twin molecules that look like mirror images to each other are called enantiomers. However, even though they have the same type and number of elements, these twin molecules exhibit completely different properties.
Professor Sukbok Chang and Dr. Yoonsu Park from the Department of Chemistry developed a new catalyst capable of selectively synthesizing only one of the two enantiomers. Using this catalyst, the have succeeded in manufacturing the chiral lactam, an essential ingredient in pharmaceuticals, from a hydrocarbon compound.
Enantiomerism or chirality is considered very important for drug development. Biomaterials, such as DNAs and proteins also have chiral properties, but they exhibit different physiological activities depending on the types of drugs. One type of the enantiomer could be useful while the other is toxic. Hence, the technology for selective synthesizing (i.e. asymmetric synthesis) is required, but it is still regarded as a great challenge faced by modern chemistry to date.
The researchers solved this problem by developing a new catalyst. Earlier they presented their research on developing an iridium catalyst that converts hydrocarbons into high value γ-lactam compounds, and published it in Science in March 2018. However, the developed catalyst still had a limitation that both types of enantiomers are obtained without selectivity.
In this study, they found that among dozens of other catalyst candidates, iridium catalysts with chiral diamine scaffolds were able to select the correct enantiomer with a selectivity of 99% or more. This novel catalyst can be used to synthesize the various chiral γ-lactam as required. A left-handed γ-lactam and a right-handed γ-lactam can be produced using a left-handed iridium catalyst and a right-handed iridium catalyst, respectively.
They analyzed the reason for the high selectivity through computational chemistry simulations. They identified that temporal hydrogen bonding occurred between the chiral diamine catalysts and the hydrocarbon compound during the reaction. As a result of the hydrogen bonding, the formation of the left-handed lactam was boosted.
With their new catalyst, they also succeeded in synthesizing chiral lactam compounds with different structures. By using inexpensive and readily available feedstock hydrocarbons, the researchers produced a group of chiral lactams in different shapes. As their chirality and diverse structures enable lactams to function as an active compound in the body for antibiotic, anti-inflammatory, or anti-tumoral functions, this study may facilitate the development of potential drugs in a more efficient and cheaper way.
Professor Chang said, “We hope that our research on selectively producing core units of effective drugs will lead to developing new drugs that demonstrate fewer side-effects and higher efficacy. There are also economic advantages of this research because it uses hydrocarbon compounds, which can be abundantly found in nature, to produce high-value raw materials.
This research was published in Nature Catalysis(10.1038/s41929-019-0230-x) on February 19, 2019.
Figure 1. Asymmetric formation of chiral γ-lactam
Figure 2. Outline of research outcome
2019.03.05 View 7611 -
The 1st Korea Toray Science and Technology Awardee, Prof. Sukbok Chang
(Distinguished Professor Sukbok Chang from the Department of Chemistry)
The Korea Toray Science Foundation (KTSF) awarded the first Korea Toray Science Technology Award in basic science to Distinguished Professor Sukbok Chang from the Department of Chemistry on September 19.
KTSF was established in January 2018, and its award goes to researchers who have significantly contributed to the development of chemistry and materials research with funds to support research projects.
Distinguished Professor Chang has devoted himself in organocatalysis research; in particular, his work on catalysts for effective lactam formation, which was an intricate problem, received great attention.
The award ceremony will take place in The Federation of Korean Industries Hall on October 31. KTFS board members, judges, and the CEO of Toray Industries Akihiro Nikkaku will attend the ceremony. Also, Dr. Ryoji Noyori, the Nobel Laureate in Chemistry, will give a talk on the role of chemistry and creative challenges as a researcher.
2018.10.04 View 8834 -
New Arylation Inducing Reaction Developed
(Professor Chang(left) and Professor Baik)
KAIST researchers have identified a reaction mechanism that selectively introduces aryl groups at the desired position of a molecule at room temperature. A team, co-led by Professor Sukbok Chang and Mu-Hyun Baik of the Department of Chemistry, used an iridium catalyst for the reaction. The team also proved that the reaction proceeds by an unusual mechanism by employing computer simulations that were substantiated with targeted experimental probes.
Hydrocarbon is an omnipresent material in nature. But its low reactivity makes it difficult to process to value-added products at the room temperature. Thus, designing catalysts that can accelerate the reaction remains an important challenge in chemistry.
In particular, since most chemicals used in medicine, pharmacy, or material chemistry contain aryl groups, an effective reaction to selectively introduce the aryl group has been an area of intensive research in organic chemistry.
In order to introduce an aryl group into stable carbon-hydrogen (C-H) bond, activation of the C-H bond with a halogen atom or organic metal is required prior to the introduction of the aryl group, or C-H functionalization directly on C-H bond is needed. Direct functionalization is more effective and economical, but most reactions require harsh reaction conditions such as high temperature or excess additives. And adding the aryl fragment selectively to only one among the many possible sites in the molecule is difficult. The new catalyst developed by these KAIST researchers is highly selective.
This work is the latest example of a successful teamwork between experimental and theoretical research groups: Computer simulations revealed that traditional approaches to arylation required high energies because the intermediates produced during the reaction are too low in energy. Based on this insight, the researchers thought of changing the character of the intermediate by oxidizing it, which was predicted to be a great way of increasing the reactivity of the catalyst. Subsequent experimental work showed that this design strategy is highly effective resulting in unprecedented chemical transformations.
Professor Chang said, “We have been able to carry out location-selective arylation at room temperature, as well as identifying a new reaction pathway, different from the conventionally suggested mechanism.” He continued, “This research is significant for identifying the reaction pathway and developing a novel selective reaction method that does not require high temperature or additives based on the mechanistic understanding. This work is a triumph of rational design, rather than fortuitous discovery.” The research findings were published online in Nature Chemistry on December 11, 2017.
(Figure 1: X-ray crystal structure transmetallation intermediate)
(Figure 2: Correlation between oxidation state of intermediate and energy barrier required for reductive elimination of intermediate as calculated using density function from computational chemistry )
(Figure 3: Arylation mechanism using iridium catalyst as suggested by the research team)
2018.01.11 View 6048 -
2016 KAIST EEWS Workshop
The Energy, Environment, Water and Sustainability (EEWS) Graduate School of KAIST hosted a workshop entitled “Progress and Perspectives of Energy Science and Technology” on October 20, 2016. The workshop took place at the Fusion Hall of the KAIST Institute on campus.
About 400 experts in energy science and engineering participated in the event. Eight globally recognized scientists introduced the latest research trends in nanomaterials, energy theory, catalysts, and photocatalysts and led discussions on the current status and prospects of EEWS.
Professors Yi Cui of Stanford University, an expert in nanomaterials, and William A. Goddard of California Institute of Technology presented their research experiments on materials design and recent results on the direction of theory under the topics of energy and environment.
Dr. Miquel Salmeron, a former head of the Material Science Division of Lawrence Berkeley National Laboratory, and Professor Yuichi Ikuhara of Tokyo University introduced their analysis of catalysts and energy matters at an atomic scale.
Professor Sukbok Chang of the Chemistry Department at KAIST, a deputy editor of ACS Catalysis and the head of the Center for Catalytic Hydrocarbon Functionalizations at the Institute of Basic Science, and Professor Yang-Kook Sun of Energy Engineering at Hanyang University, who is also a deputy editor of ACS Energy Letters, presented their latest research results on new catalytic reaction development and energy storage.
The workshop consisted of three sections which addressed the design of energy and environment materials; analysis of energy and catalytic materials; and energy conversion and catalysts.
The EEWS Graduate School was established in 2008 with the sponsorship of the Korean government’s World Class University (WCU) project to support science education in Korea. Professor J. Fraser Stoddart, the winner of the 2016 Nobel Prize in Chemistry, was previously worked at the KAIST EEWS Graduate School as a WCU visiting professor for two years, from 2011 to 2013. Professor Ali Coskun, who was a postdoctoral researcher in the laboratory of Professor Stoddart, now teaches and conducts research as a full-time professor at the graduate school.
Dean Yousung Jung of the EEWS Graduate School said:
“This workshop has provided us with a meaningful opportunity to engage in discussions on energy science and technology with world-class scholars from all around the world. It is also a good venue for our graduate school to share with them what we have been doing in research and education.”
2016.10.20 View 12991 -
Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award.
Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years.
Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years.
Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells.
Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23 View 12397