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2017 KAIST Research Day Honors Professor Hoon Sohn
The 2017 KAIST Research Day recognized Professor Hoon Sohn of the Department of Civil and Environmental Engineering as Research Grand Prize Awardee in addition to the 10 most distinguished research achievements of the past year. The Research Grand Prize recognizes the professor whose comprehensive research performance evaluation indicator is the highest over the past five years. The indicator combines the factors of the number of research contracts, IPR, royalty income, as well as research overhead cost inclusion. During the ceremony, which was held on May 23, Professor Jun-Ho Oh of the Department of Mechanical Engineering and Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering also won the Best Research Award. The two professors had the best scores when evaluating their research performance for one-year periods. Meanwhile, the Research Innovation Award went to Professor YongKeun Park of the Department of Physics. The Research Innovation Award scores the factors of foreign patent registration, contracts of technological transfer and income from technology fees, technology consultations, and startups and selected Professor Park as the top winner. Professors Yong Hee Lee of the Department of Physics and Jonghwa Shin of the Department of Material Science won the Convergence Research Award. The Convergence Research Award recognizes the most outstanding research team who created innovative research results for a year. After the ceremony, President Chen Shiyi of the Southern University of Science and Technology gave a distinguished lecture on the “Global & Entrepreneurial Universities for the Age of the Fourth Industrial Revolution.” the Research Day ceremony, KAIST also presented the ten most distinguished research achievements made by KAIST professors during the last year as follows (Click): ▲ Commercialization of 3D Holographic Microscopy by Professor YongKeun Park of the Department of Physics ▲ Designer Proteins with Chemical Modifications by Professor Hee-Sung Park of the Department of Chemistry ▲ Lanthanum-Catalyzed Synthesis of Microporous 3D Graphene-Like Carbons in a Zeolite Template by Professor Ryong Ryoo of the Department of Chemistry ▲ Complete Prevention of Blood Loss by Self-Sealing Hemostatic Needles by Professor Haeshin Lee of the Department of Chemistry ▲ An Immunological Mechanism for the Contribution of Commensal Microbiota Against Herpes Simplex Virus Infection in Genital Mucosa by Heung Kyu Lee of the Graduate School of Medical Science and Engineering ▲ Development of a Pulse-Echo Laser Ultrasonic Propagation Imaging System by Professor Jung-Ryul Lee of the Department of Aerospace Engineering ▲ Bi-refractive Stereo Imaging for Single-Shot Depth Acquisition by Professor Min H. Kim of the School of Computing ▲ Development of Environment Friendly Geotechnical Construction Material Using Biopolymer by Professor Gye-Chun Cho of the Department of Civil and Environmental Engineering ▲ Protein Delivery Via Engineered Exosomes by Professor Chulhee Choi of the Department of Bio and Brain Engineering ▲ Hot Electron Detection Under Catalytic Reactions by Professor Jeong Young Park of the Graduate School of EEWS. After the ceremony, President Chen Shiyi of the Southern University of Science and Technology gave a distinguished lecture on the “Global & Entrepreneurial Universities for the Age of the Fourth Industrial Revolution.” (Photo:President Shin poses with the 2017 KAIST Research Grand Prize Winner Professor Hoon Sohn on May 23.)
2017.05.23
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Prof. Sang-Min Bae Receives 2017 iF Design Award
Prof. Sang-Min Bae and his research team from the Industrial Design Department of KAIST submitted a winning entry to the 2017 iF Design Award named ‘Culture BOXCHOOL’. The iF Design Award is an internationally renowned design contest that is recognized as one of the top three design awards in the world along with the Red Dot Design Award and the IDEA Design Award. It has been held annually by iF International Forum Design since 1953. A total of 5,575 entries from 59 countries entered the last competition. Culture BOXCHOOL is a modular container space platform designed for culture sharing in isolated areas. It is delivered as a standard shipping container along with its subsidiary modular parts and it transforms into a gallery, office, or classroom. These modular parts build the interior and exterior by attaching them to the corner castings, which are standard parts on all shipping containers. Two Cultural BOXCHOOL containers can be transformed into three different types of layouts. The containers can generate their own energy using solar panels that provide sustainable energy to equipment inside. Additionally, hot humid air can flow out through the attic vent, doors, and windows. “With Culture BOXCHOOL, you can easily and quickly create spaces such as offices and classrooms, or you can easily disassemble and move them to another location. Thus, it can provide everyone with equal educational opportunities and cultural enjoyment regardless of their geographical location. In addition, because it produces its own energy, it is expected to create a cultural space in a relatively harsh environment such as in developing countries. These social and economic values of Culture BOXCHOOL seem to be what led to us winning the contest. I will continue to strive to create the world’s best designs for needy people.” Professor Bae said. The ID+IM design laboratory, a research team led by Professor Bae, has been studying philanthropy design since 2005, working on solving various problems throughout society through innovative design. They have received more than 50 awards from the most prestigious design competitions in the world.
2017.05.18
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Distinguished Professor Lee Elected to the NAS
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering was elected as a foreign associate to the US National Academy of Sciences (NAS) on May 2. The National Academy of Sciences elected 84 new members and 21 foreign associates in recognition of their distinguished and continuing achievements in their original research. Election to the Academy is widely regarded as one of the highest honors that a scientist can receive. Professor Lee was also elected in 2010 as a member of the US National Academy of Engineering (NAE) for his leadership in microbial biotechnology and metabolic engineering, including the development of fermentation processes for biodegradable polymers and organic acids. Until 2016, there are only 12 people worldwide who are foreign associates of both NAS and NAE. He is the first Korean elected to both prestigious academies, the NAS and the NAE in the US. Professor Lee is currently the dean of KAIST Institutes, the world leading institute for multi-and interdisciplinary research. He is also serving as co-chair of the Global Council on Biotechnology and member of the Global Future Council on the Fourth Industrial Revolution, the World Economic Forum.
2017.05.16
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Dr. Zi Jing Wong Named 2017 Jeong Hun Cho Awardee
(Photo caption: The 2017 Jeong Hun Cho Scholarship recipients pose with President Shin (left photo) and Dr. Zi Jing Wong, the recipient of the 2017 Jeong Hun Cho Award) Dr. Zi Jing Wong, a postdoctoral scholar at the University of California, Berkeley was named the 2017 recipient of the Jeong Hun Cho Award. The award recognizes outstanding young scientists in the field of aerospace engineering annually. The recipient receives a 20 million KRW prize. The Award Committee said that Dr. Wong who earned his MS at KAIST Department of Aerospace Engineering is a rising scholar in the fields of optic meta materials, photonics, imaging, among others. He has published five papers on the realization of a zero refractive index and the control of a refractive index, as well as the realization of a 3D invisibility cloak in Science and Nature Photonics in 2014 and 2015. Dr. Wong also swept the best paper awards from many international academic societies including the US Materials Research Society, IEEE, SPIE, and Metamaterials Congress in 2015. He finished his Ph.D. at the University of California, Berkeley. The Award Committee also named three recipients of the Jeong Hun Cho Scholarship: Ph.D. candidate Hyon-Tak Kim of the Department of Aerospace Engineering at KAIST, Ph.D. candidate Ho-Song Park from the Department of Mechanical Engineering at Korea University, and Hyong-Jin Choi of Kongju National University High School. The award was endowed by the family of the late Ph.D. candidate Jeong Hun Cho who died in a rocket lab accident in the Department of Aerospace Engineering in 2003. Cho was posthumously conferred an honorary doctorate degree. In memory of Cho, his father established the ‘Jeong Hun Cho Award and Scholarship.’ The scholarship annually selects three young scholars from Cho’s alma maters of KAIST, Korea University, and Kongju National University High School.
2017.05.12
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Professor Lee Recognized by the KMS as Best Paper Awardee
Professor Ji Oon Lee of the Department of Mathematical Sciences was selected as the 2017 Best Paper Awardee by the Korean Mathematical Society. The award will be presented during the KMS spring meeting on April 29. Dr. Lee is being honored for proving a necessary and sufficient condition for the Tracy-Wisdom law of Wigner matrices. In a paper titled ‘A Necessary and Sufficient Condition for Edge Universality of Wigner Matrices,’ he proposed a solution for one of the many unanswered problems in the field of random matrix theory that have existed for decades. The paper, co-authored with Professor Jun Yin at the University of Wisconsin – Madison, was published in the Duke Mathematical Journal in 2014. Professor Lee joined KAIST in 2010 after finishing his Ph.D. at Harvard University. He was named a ‘POSCI Science Fellow’ and received the ‘Young Scientist Award’ from the KMS in 2014.
2017.04.27
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Professor Duck-Joo Lee Awarded the 21st Century Grand Prize
Professor Duck-Joo Lee of the Department of Aerospace Engineering was awarded the 21st Century Grand Prize in the field of technology development by the New Industry Management Academy and the 21st Leaders Club on April 13. Professor Lee was honored in recognition of his contribution to the helicopter industry. He played a part in domestic helicopter development projects including the KUH-1 Surion (Korean Attack Helicopter), a twin-engine, transport utility helicopter as well as LAH (Light Armed Helicopter) and LCH (Light Civil Helicopter) projects. Since joining KAIST in 1988, Professor Lee supervised more than 26 PhDs and 27 MSs. He was responsible for hosting the 1st Asian-Australian Rotorcraft Forum and Exhibition and currently serves as vice president of the American Helicopter Society and the Korea Drone Industry Promotion Association. He also participated in open online courses on K-MOOC and Coursera. (Caption: Professor Lee (second from left in the first row) poses after receiving the award.)
2017.04.26
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2017 Summer Nuclear Nonproliferation Education Program
The Nuclear Nonproliferation Education and Research Center (NEREC) at KAIST announced its 30 scholarship recipients for the 2017 Summer Nuclear Nonproliferation Education Program on April 18. The six-week program, starting from July 10, will be run in Korea, Japan, and China. The program provides young global scholars with focused and challenging nuclear nonproliferation studies. Young scholars will be exposed to diverse science and technology policies and practices concurrently conducted in many countries and the future direction for enhancing nuclear nonproliferation. They will participate in a series of seminars, projects, international conferences, and field trips. Since its launch in 2014, the program has educated 71 young scholars. This year, more than 150 scholars from 37 countries applied for the program, reflecting the growing reputation of the program both at home and abroad. The director of the NEREC, Professor Man-Sung Yim of the Department of Nuclear and Quantum Engineering at KAIST said that young scholars from very prestigious foreign universities have shown strong interest in the program. According to Professor Yim, this year’s recipients are from 26 universities from 16 countries including Harvard University, Oxford University, the National Research Nuclear University of Russia, and the Tokyo Institute of Technology
2017.04.19
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Nuclease-Resistant Hybrid Nanoflowers
An eco-friendly method to synthesize DNA-copper nanoflowers with high load efficiencies, low cytotoxicity, and strong resistance against nucleases has been developed by Professor Hyun Gyu Park in the Department of Chemical and Biomolecular Engineering and his collaborators. The research team successfully formed a flower-shaped nanostructure in an eco-friendly condition by using interactions between copper ions and DNA containing amide and amine groups. The resulting nanoflowers exhibit high DNA loading capacities in addition to low cytotoxicity. Flower-shaped nanocrystals called nanoflowers have gained attention for their distinct features of high surface roughness and high surface area to volume ratios. The nanoflowers have been used in many areas including catalysis, electronics, and analytical chemistry. Of late, research breakthroughs were made in the generation of hybrid inorganic-organic nanoflowers containing various enzymes as organic components. The hybridization with inorganic materials greatly enhanced enzymatic activity, stability, and durability compared to the corresponding free enzymes. Generally, the formation of protein nanocrystals requires high heat treatment so it has limitations for achieving the high loading capacities of intact DNA. The research team addressed the issue, focusing on the fact that nucleic acids with well-defined structures and selective recognition properties also contain amide and amine groups in their nucleobases. They proved that flower-like structures could be formed by using nucleic acids as a synthetic template, which paved the way to synthesize the hybrid nanoflowers containing DNA as an organic component in an eco-friendly condition. The team also confirmed that this synthetic method can be universally applied to any DNA sequences containing amide and amine groups. They said their approach is quite unique considering that the majority of previous works focused on the utilization of DNA as a linker to assemble the nanomaterials. They said the method has several advantageous features. First, the ‘green’ synthetic procedure doesn’t involve any toxic chemicals, and shows low cytotoxicity and strong resistance against nucleases. Second, the obtained nanoflowers exhibit exceptionally high DNA loading capacities. Above all, such superior features of hybrid nanoflowers enabled the sensitive detection of various molecules including phenol, hydrogen peroxide, and glucose. DNA-copper nanoflowers showed even higher peroxidase activity than those of protein-copper nanoflowers, which may be due to the larger surface area of the flower- shaped structures, creating a greater chance for applying them in the field of sensing of detection of hydrogen peroxide. The research team expects that their research will create diverse applications in many areas including biosensors and will be further applied into therapeutic applications. Professor Park said, “The inorganic component in the hybrid nanoflowers not only exhibits low cytotoxicity, but also protects the encapsulated DNA from being cleaved by endonuclease enzymes. Using this feature, the nanostructure will be applied into developing gene therapeutic carriers.” This research was co-led by Professor Moon Il Kim at Gachon University and KAIST graduate Ki Soo Park, currently a professor at Konkuk University, is the first author. The research was featured as the front cover article of the Journal of Materials Chemistry B on March 28, Issue 12, published by the Royal Society of Chemistry. The research was funded by the Mid-Career Researcher Support Program of the National Research Foundation of Korea and the Global Frontier Project of the Ministry of Science, ICT & Future Planning. (Figure: (A) Schematic illustration of the formation of nuclease-resistant DNA–inorganic nanoflowers. (B) SEM images showing time-dependent growth of DNA-nanoflowers. The concentration of A-rich ssDNA (Table S1, ESI†) was 0.25 mM.)
2017.04.14
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Professor Won Do Heo Receives 'Scientist of the Month Award'
Professor Won Do Heo of the Department of Biological Sciences was selected as the “Scientist of the Month” for April 2017 by the Ministry of Science, ICT and Future Planning and the National Research Foundation of Korea. Professor Heo was recognized for his suggestion of a new biological research method developing various optogenetics technology which controls cell function by using light. He developed the technology using lasers or LED light, without the need for surgery or drug administration, to identify the cause of diseases related to calcium ions such as Alzheimer’s disease and cancer. The general technique used in optogenetics, that control cells in the body with light, is the simple activation and deactivation of neurons. Professor Heo developed a calcium ion channel activation technique (OptoSTIM1) to activate calcium ions in the body using light. He also succeeded in increasing calcium concentrations with light to enhance the memory capacity of mice two-fold. Using this technology, the desired amount and residing time of calcium ion influx can be controlled by changing light intensity and exposure periods, enabling the function of a single cell or various cells in animal tissue to be controlled remotely. The experimental results showed that calcium ion influx can be activated in cells that are affected by calcium ions, such as normal cells, cancer cells, and human embryonic stem cells. By controlling calcium concentrations with light, it is possible to control biological phenomena, such as cellular growth, neurotransmitter transmission, muscle contraction, and hormone control. Professor Heo said, “Until now, it was standard to use optogenetics to activate neurons using channelrhodopsin. The development of this new optogenetic technique using calcium ion channel activation can be applied to various biological studies, as well as become an essential research technique in neurobiology. The “Scientist of the Month Award” is given every month to one researcher who made significant contributions to the advancement of science and technology with their outstanding research achievement. The awardee will receive prize money of ten million won.
2017.04.07
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Expanding the Genetic Code of Mus Musculus
Professor Hee-Sung Park of the Department of Chemistry, who garnered attention for his novel strategy of installing authentic post-translational modifications into recombinant proteins, expanded his research portfolio to another level. Professor Park’s team was the first to report the generation of a mouse strain with an expanded genetic code, allowing site-specific incorporation of unnatural amino acids. Professor Park published the research on the new chemical biology method for achieving selective chemical modifications in proteins in Science last September. The research team, this time in collaboration with Professor Chan Bae Park of the Department of Physiology at the Ajou University School of Medicine, demonstrated temporal and spatial control of protein acetylation in various organs of the transgenic mouse using a recombinant green fluorescent protein as a model protein. This research was published in the online edition of Nature Communications on February 21. This approach enables the rapid onset of position-specific acetylation of a target protein at any developmental stage, facilitating temporal and spatial control of protein acetylation in various organs of the transgenic mouse. Such temporal and spatial control of protein acetylation will be of prime importance for investigating many essential biological processes and human diseases at the tissue and organism level. Almost all human proteins, the products of about 25,000 genes, are known to undergo various post-translational modifications during and after synthesis. Post-translation modifications regulate the function of cellular proteins, playing a key role in many essential processes such as delivering signals and body growth. However, the unusual protein modifications, aroused from genetic and/or environmental factors, trigger severe diseases including cancer, dementia, and diabetes. The team inserted transgenes into the mouse genome to allocate the site-specific addition of unnatural amino acids. The researchers inserted a modified version of lysine into the house mice, which allowed for the control of the acetylation. They used recombinant green fluorescent proteins from transgenic house mice as models for control of the acetylation. The team was also able to regulate the acetylation of specific temporal and spatial frames in the mice, restraining the abnormality in proteins to certain organs such as the liver and kidneys. The research team said the strategy will provide a powerful tool for systematic in vivo study of cellular proteins in the most commonly used mammalian model organisms for human physiology and disease. Professor Park said, “This method can be easily extended to generate a wide range of custom-made transgenic mouse strains for further investigating diverse proteins of interest.” He added, “This method can be further extended to generate a wide range of custom-made transgenic mouse strains, opening a new paradigm for investigating anti-cancer and cerebral disease treatments. This work was supported by grants from KAIST Systems Healthcare and the Medicinal Bioconvergence Research Center and the Intelligent Synthetic Biology Center of the Global Frontier Project funded by the Ministry of Science, ICT & Future Planning and the Ministry of Food and Drug Safety. (Figure:Temporal and spatial control of in vivo protein acetylation) (a) Temporal expression of acetylated GFPuv in the AcK-GFPamber mouse. The expression of GFPuv in skeletal muscle, liver, and lung tissues was detected only in the AcK-injected mouse. Scale bar, 200 µm. (b) Western blotting of anti-FLAG-immunoprecipitated proteins from tissues of the AcK-GFPamber mouse. Acetylated GFPuv was produced after AcK injection. (c) Spatial expression of acetylated GFPuv in the AcK-GFPamber mouse. Acetylated GFPuv was observed only in skeletal muscle when AcK was directly delivered to the tissues. Sacle bar, 200 µm.
2017.03.27
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Professor Jae Kyoung Kim Receives the 2017 HSFP Award
The Human Frontier Science Program (HSFP), one of the most competitive research grants in life sciences, has funded researchers worldwide across and beyond the field since 1990. Each year, the program selects a handful of recipients who push the envelope of basic research in biology to bring breakthroughs from novel approaches. Among its 7,000 recipients thus far, 26 scientists have received the Nobel Prize. For that reason, HSFP grants are often referred to as “Nobel Prize Grants.” Professor Jae Kyoung Kim of the Mathematical Sciences Department at KAIST and his international collaborators, Professor Robert Havekes from the University of Groningen, the Netherlands, Professor Sara Aton from the University of Michigan in Ann Arbor, the United States, and Professor Matias Zurbriggen from the University of Düsseldorf, Germany, won the Young Investigator Grants of the 2017 HSFP. The 30 winning teams of the 2017 competition (in 9 Young Investigator Grants and 21 Program Grants) went through a rigorous year-long review process from a total of 1,073 applications submitted from more than 60 countries around the world. Each winning team will receive financial support averaging 110,000-125,000 USD per year for three years. Although Professor Kim was trained as a mathematician, he has extended his research focus into biological sciences and attempted to solve some of the most difficult problems in biology by employing mathematical theories and applications including nonlinear dynamics, stochastic process, singular perturbation, and parameter estimation. The project that won the Young Investigator Grants was a study on how a molecular circadian clock may affect sleep-regulated neurophysiology in mammals. Physiological and metabolic processes such as sleep, blood pressure, and hormone secretion exhibit circadian rhythms in mammals. Professor Kim used mathematical modeling and analysis to explain that the mammalian circadian clock is a hierarchical system, in which the master clock in the superchiasmatic nucleus, a tiny region in the brain that controls circadian rhythms, functions as a pacemaker and synchronizer of peripheral clocks to generate coherent systematic rhythms throughout the body. Professor Kim said, “The mechanisms of our neuronal and hormonal activities regulating many of our bodily functions over a 24-hour cycle are not yet fully known. We go to sleep every night, but do not really know how it affects our brain functions. I hope my experience in mathematics, along with insights from biologists, can find meaningful answers to some of today’s puzzling problems in biological sciences, for example, revealing the complexities of our brains and showing how they work.” “In the meantime, I hope collaborations between the fields of mathematics and biology, as yet a rare phenomenon in the Korean scientific community, will become more popular in the near future.” Professor Kim received his doctoral degree in Applied and Interdisciplinary Mathematics in 2013 from the University of Michigan and joined KAIST in 2015. He has published numerous articles in reputable science journals such as Science, Molecular Cell, Proceedings of the National Academy of Sciences, and Nature Communications. Both the Program Grants and Young Investigator Grants support international teams with members from at least two countries for innovative and creative research. This year, the Program Grants were awarded to research topics ranging from the evolution of counting and the role of extracellular vesicles in breast cancer bone metastasis to the examination of obesity from a mechanobiological point of view. The Young Investigator Grants are limited to teams that established their independent research within the last five years and received their doctoral degrees within the last decade. Besides Professor Kim’s study, such topics as the use of infrasound for navigation by seabirds and protein formation in photochemistry and photophysics were awarded in 2017. Full lists of the 2017 HFSP winners are available at: http://www.hfsp.org/awardees/newly-awarded. About the Human Frontier Science Program (HFSP): The HFSP is a research funding program implemented by the International Human Frontier Science Program (HFSPO) based in Strasbourg, France. It promotes intercontinental collaboration and training in cutting-edge, interdisciplinary research specializing in life sciences. Founded in 1989, the HFSPO consists of the European Union and 14 other countries including the G7 nations and South Korea.
2017.03.21
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6 Subjects of KAIST Ranked in the Top 20 in the World
Six disciplines of KAIST have emerged among the top 20 in the world. The 2017 QS World University Rankings by Subject rated Materials Science at KAIST 13th in the global ranking. Other subjects ranked within top 20 include Chemical and Biomolecular Engineering (15th), Civil and Environmental Engineering (15th), Mechanical and Aerospace Engineering (15th), Electrical Engineering (17th), and Chemistry (18th). This year, two more disciplines advanced into the top 20 from four in 2016. QS ranked KAIST as the top science and technology research university in Korea. KAIST earned the highest global rankings among Korean universities in the following seven areas: Materials Science and Engineering (13th), Chemical and Biomolecular Engineering (15th), Civil and Environmental Engineering (15th), Mechanical and Aerospace Engineering (15th), Electrical Engineering (17th), Chemistry (18th), and the School of Computing (33th). In addition, two more disciplines of Physics (44th) and Mathematical Sciences (47th) were ranked second among domestic universities. The London-based university ranking by Quacquarelli Symonds, Ltd. announced the global university ranking by 46 subjects on March 8. QS rankings are based on academic reputation, employer reputation, the number of research citations, and research accomplishment index (H-index).
2017.03.09
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