Department+of+Biological+Science
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Genetic Cause of ADHD (Attention Deficit Hyperactivity Disorder) Found
The cooperative research team consisting research teams under Professor Kim Eun Joon and Professor Kang Chang Won of the department of Biological Sciences discovered that ADHD arises from the deficiency of GIT1 protein in the brain’s neural synapses.
ADHD (Attention Deficit Hyperactivity Disorder) is found in around 5% of children around the world and is a disorder where the child becomes unable to concentrate, show over the top responses, and display impulsive behavior.
The research team found that the difference between children with ADHD and those without it is one base in the GIT1 gene. The difference of a single base causes the underproduction of this protein, and those children with low levels of the protein had a higher probability to develop ADHD.
In addition, further evidence was provided when the research team conducted mice experiments. Those mice with low levels of GIT1 exhibited impulsive and exaggerated reactions like humans with ADHD, had learning disabilities, and produced abnormal brain waves. And upon injecting these mice with cure for ADHD, the symptoms of ADHD disappeared.
The impulsive behavior of ADHD children disappears as the child enters adulthood and a similar pattern was found in mice. A mice with low levels of GIT1 showed impulsive behaviors when 2 months old, but these behaviors disappeared as it got older to around 7 months old (equivalent to 20~30 years old for humans).
Professor Kim Eun Joon commented that there has to be equilibrium between mechanisms that excite the neurons and mechanisms that calm the neurons, but the lack of GIT1 leads to the decrease in the mechanisms that calm the neurons which causes the impulsive behavior of ADHD patients.
In addition, Professor Kang Chang Won commented that the results of the experiment has been receiving rave reviews and is being seen as the new method in the production of the cure for ADHD.
The result of the experiment was published in the online edition of Nature Medicine magazine.
2011.04.30 View 12327 -
New Bio-Clock gene and its function found
The Ministry of Education, Science and Technology announced that a Korean research team has found a new gene responsible for maintaining the bio-clock (twenty-four) and its mechanism.
Twnety-four was led by Professor Choi Joon Ho and Dr. Lee Jong Bin of KAIST (department of Biology) and was a joint operation with Professor Ravi Allada and Dr.Lim Jeong Hoon of Northwestern University (department of neurobiology) and the result was published in ‘Nature’ magazine.
The research team experimented with transformed small fruit flies for 4 years and found that there was an undiscovered gene that deals with the bio rhythm in the brain which they named ‘twenty-four’.
The understanding with genes prior to twenty-four was that these genes regulate biorhythm in the transcription phase (DNA to mRNA). Twenty-four operates in the step after transcription when the ribosome creates proteins. Especially twenty-four has a great effect on the ‘period protein’ which acts as a sub-atomic clock that regulates the rhythm and life of each cell.
The experiment was innovational in that it was able to scientifically prove the function of the protein produced by the gene.
The result is expected to help solve the problems associated with sleep disorders, jetlags, eating rhythms, bio rhythms, etc.
The name twenty-four was the fact that a day, a cycle, is 24 hours long and the gene’s serial numbers CG4857 adds up to twenty four.
2011.02.23 View 13946
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College of Cultural Science selects 'Best English Paper' Recipients
KAIST’s College of Cultural Science (Dean Kim Dong Won) announced the winners of ‘2010 Fall Semester Best English Paper Award’: Excellence Award went to Kwak Ah Young (department of Biology), Seong Du Hyun (undeclared major), Ahn Da In (Biological Chemical Engineering), and nine other students received the Participation Award.
Ahn Da In discussed ‘Joyce and Chopin on use of epiphany’, Seong Du Hyun discussed ‘On Kant’s Groundwork for the metaphysics of Morals, its Achievements, and Implications’, and Kwak Ah Young discussed ‘Fact Pattern of Environmental Law’.
The ‘Best English Paper’ Award has been awarded to undergraduates since 2009 Fall semester in the Humanities and Social Science Department’s efforts to increase creativity and English writing skills of students attending KAIST.
For the 2010 fall semester, each professor in charge went through 1 to 2 papers (among 610 papers admitted across human science subjects) and recommended 29 papers to be discussed with great scrutiny. The evaluation took place throughout January and the 3 papers discussing English Literature, Scientific Philosophy, and Environmental Law were awarded the Excellence Award, and 9 other papers were awarded the Participation Award.
Dean of Cultural Science College Kim Dong Won commented, ‘I am very encouraged by the level of papers and is becoming a very large art of the College of Cultural Science’.
The chairman of the screening committee, Professor Kim Eun Kyung also commented, ‘the best paper award is helping students better their English levels’ and that ‘in order to form and encourage a sound and structured English paper writing environment, a anti-plagiarism program will be implemented amongst implementing other judging standards’.
2011.02.21 View 12755
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The 40th Anniversary of the Establishment of KAIST Commemoration Held
KAIST, aspiring to become the best Science and Technology University, has turned 40.
KAIST held the commemoration ceremony for the 40th Anniversary of the Establishment of KAIST in the auditorium.
Five awards (Scholar, Creative Lecture, Excellence in Lecture, International Cooperation, Experiment) were given to Professors Kim Eun Jun and Walton Jones (department of Biology), Professor Abigail Shin (department of Humanities and Social Sciences), Professor Shin Seong Chul (department of Physics), and Professor Lee Sang Yeop (department of Biological Chemical Engineering). Each recipient received a prize of five million won.
Professor Song Joon Hwa (department of Computer Sciences) received the ‘New Knowledge Award’ in recognition of his development of the Orchestrator Mobile platform. The new platform is different from Android or the IOS platform in that it allows a fluid relationship to be formed between the smartphone and the user.
KAIST also showed off its new emblem.
The emblem consists of a star which represents the KAIST’s goals of becoming the world leader, of training leaders, the center point, and hope. The main keywords are: ‘Leadership’, ‘Premium’, ‘Scientific’, and ‘Humanity’.
KAIST plans on having various events from May 9th when there will be the Vision Declaration.
2011.02.21 View 16992
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Success in differentiating Functional Vascular Progenitor Cells (VPC)
KAIST’s Professor Han Yong Man successfully differentiated vascular progenitor cells from human embryonic stem cells and reversed differentiated stem cells.
The research went beyond the current method of synthesis of embryonic body or mice cell ball culture and used the careful alteration of signal transmission system of the human embryonic stem cells to differentiate the formation of vascular progenitor cells.
The team controlled the MEK/ERK and BMP signal transmission system that serves an important role in the self replication of human embryonic stem cells and successfully differentiated 20% of the cells experimented on to vascular progenitor cells.
The vascular progenitor cells produced with such a method successfully differentiated into cells forming the endodermis of the blood vessel, vascular smooth muscle cells and hematopoietic cells in an environment outside of the human body and also successfully differentiated into blood vessels in nude mice.
In addition, the vascular progenitor cell derived from human embryonic cells successfully formed blood vessels or secreted vascular growth factors and increased the blood flow and the necrosis of blood vessels when injected into an animal with limb ischemic illness.
The research was funded by the Ministry of Education, Science and Technology, 21st Century Frontier Research and Development Institution’s Cell Application Research Department and Professor Ko Kyu Young (KAIST), Professor Choi Chul Hee (KAIST), Professor Jeong Hyung Min (Cha Medical School) and Doctor Jo Lee Sook (Researcher in Korea Bio Engineering Institute) participated in it.
The results of the research was published as the cover paper of the September edition of “Blood (IF:10.55)”, the American Blood Journal and has been patented domestically and has finished registration of foreign PCT.
The results of the experiment opened the possibility of providing a patient specific cure using stem cells in the field of blood vessel illness.
2011.01.18 View 16115 -
KAIST was invited to the World Economic Forum's fourth "Summer Davos."
KAIST attended the World Economic Forum’s “Summer Davos Forum” held from September 13 to 15 in Tianjin, China. The Summer Davos Forum hosted various sessions and meetings with international dignitaries from governments, business and public organizations, and academia on the main theme of “Driving Growth through Sustainability.”
On September 14, four subjects including “Electric Vehicles,” “Humanoid Robotics,” “Next Generation of Biomaterials,” and “New Developments in Neuroengineering” were presented by KAIST, followed by discussions with forum participants.
Professor Jae-Seung Jeong of the Bio and Brain Engineering Department, Sang-Yup Lee of the Chemical and Biomolecular Engineering Department, Joon-Ho Oh of the Mechanical Engineering Department, and President Nam-Pyo Suh participated in the forum as presenters of the topic. Of these speakers, Professors Jae-Seung Jeong and Sang-Yup Lee were nominated by the World Economic Forum (WEF) as members of the “Young Global Leader” and “Global Agenda Council on Emerging Technologies,” respectively.
President Suh was also invited to the CEO Insight Group and delivered an opening speech on OLEV (Online Electric Vehicle) and the Mobile Harbor. President Suh plans to sign an MOU for research cooperation with Jong-Hoo Kim of Bell Lab and Shirley Jackson of the Rensselaer Polytechnic Institute in the near future, respectively.
Since 2007, the WEF, in charge of the world’s largest international conference called “Davos Forum” has hosted a “Summer Davos Forum,” also called as the “Annual Meeting of New Champions.” The Summer Davos Forum consists of nations, rising global companies, next generation of global leaders, and cities or nations that lead technological innovations. Unlike the annual Davos Forum held in January, the “Annual Meeting of New Champions” is held in September of each year in Tianjin and Dalian, China.
Since 2009, the WEF has added a special session called IdeasLab in the Davos and Summer Davos Forums. Through IdeasLab, prominent universities from all over the world, research organizations, venture businesses, NGOs, and NPOs are invited to exchange and discuss innovative and creative ideas that can contribute to the development of mankind. Until now, universities including INSEAD, EPFL-ETH, MIT, Oxford, Yale, Harvard, Rensselaer Polytechnic Institute, Tsinghua University, and Keio University have been invited to the IdeasLab. KAIST is the first Korean university to attend this session.
2010.09.17 View 23332 -
KAIST Prof. Park Selected as Winner of Clemson Award
Professor Tae-Gwan Park of the Department of Biological Sciences, KAIST, was chosen as the winner of the 2009 Clemson Award for Fundamental Research, university authorities said on Tuesday (April 7).
The award is the highest recognition of the Society for Biomaterials, an international organization of more than 3,000 members that promotes research in the field of biomaterials. Prof. Park is cited for his outstanding achievements in interdisciplinary research covering gene transferring, gene therapy and neogenesis. It is rare for a non-U.S. national to win the prize in the 36-year history of the award.
The award will be given to Professor Park at the Annual Meeting of the society which will be held in San Antonio, Texas, on April 22.
2009.04.09 View 14157 -
Prof. Chung Named Winner of 2008 KAIST Scientific Award
Professor Chung Jong-Kyeong of the Department of Biological Sciences was named the winner of the 2008 KAIST Scientific Award.
The prize was awarded by KAIST President Suh Nam-Pyo during the 37th KAIST anniversary ceremony on Feb. 16.
Chung was cited for disclosing the new anti-cancer aspect of adenosine monophosphate-activated protein kinase (AMPK). His papers, published in the science magazine Nature in 2006 and again in 2007, revealed that the protein could be used to treat certain forms of cancer, as well as prevent malignant growths.
2008.02.28 View 14730 -
Professor Eunjoon Kim's team finds synapse-forming protein
Professor Eunjoon Kim’s team finds synapse-forming protein
- discover a new protein ‘NGL’ that promotes the formation of neuronal synapses
- can presume the cause of various brain disorders including schizophrenia
- will be published at Nature Neuroscience Vol. 9 in September
A new protein that promotes the formation of synapses in human brains was discovered by a Korean research team.
The team led by Eunjoon Kim, Professor of Department of Biological Sciences and Head of Creative Research Group of Synapse Formation), announced that it had discovered a new fact that NGL protein promotes the formation of neuronal synapses and this fact would be published in Nature Neuroscience Vol. 9 on September 18.
Professor Kim’s team discovered that a membrane protein named ‘NGL’ located at post synapse links with other membrane protein named netrin-G in pre synapse, acting as crosslink, and promotes the formation of a new synapse.
‘NGL’ is the second protein found to crosslink synapse, following neuoroligin. With the discovery of this new protein, the principle of synapse formation and the causes of various brain disorders can be presumed.
In the human brain, about more than 100 billion neuron cells and about 10,000 synapses compose neural circuit. A synapse is the place where innervation occurs between neuron cells. The formation of synapse induces the formation of neural circuit, and neural circuit is deeply related with various brain disorders as well as normal development of brains or brain functions.
“As netrin-G linked with NGL is related with schizonphrenia and neuoroligin and synapse crosslinking protein having a similar function with NGL is deeply related with mental retardation and autism, I think NGL is related with various brain disorders including schizophrenia.”
<Explanation of attached photos>
■ Photo1: Experiment for confirming NGL’s ability to form synapse No. 1
Mix ordinary cell (green) revealing NGL at its surface and neuron cell. Axon grows toward NGL (ordinary cell) located in the middle of ten o’clock direction and meets NGL, where NGL induces the formation of pre synapse (red) in the contacting axon.
Whether pre synapse has been formed can be told by the fluorescent dying (red) of pre synapse protein named Synapsin.
- Figure a-b: formation of synapse by NGL
- Figure c-d: transformed NGL losing synapse forming ability cannot form synapse
■ Photo 2: Experiment for confirming NGL’s ability to form synapse No. 2
When beads coated with NGL are scattered on neuron cell, the beads contact with the axon of the neuron cell (the beads are clearly visible at the phase differentiation image in the middle panel). At this time, NGL induces the formation of pre synapse (red) in the axon. Whether pre synapse has been formed can be told by the fluorescent dying (red) of pre synapse protein named SynPhy (panel a) or VGlut1 (panel b).
2006.09.21 View 17609
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Professor Tae-Gwan Park awarded Minister Prize
Professor Tae-Gwan Park awarded Minister Prize
Professor Tae-Gwan Park (Department of Biological Sciences) was awarded the Minister Prize in the science innovation sector at the NANO KOREA 2006, which was opened on August 30.
This prize is given to researchers who have shown excellent research results in the field of Nanotechnology, and Professor Park was awarded the Minister Prize in recognition of his innovative achievements in the fields of Tissue Engineering, Drug Delivery, Gene Therapy, which are fusion technologies of NT and BT that utilize nanobiomaterials.
2006.09.06 View 16463
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Gene Protecting Brain Nerves Discovered
THE KOREA TIMES 2005.1.31By Kim Tae-gyu / Staff Reporter
South Korean scientists have for the first time discovered genes tasked with protecting brain nerves.
Korea Advanced Institute of Science and Technology professor Kim Jae-seob said Sunday the new genes, named pyrexia, shield brain nerves from outside stimuli, including high temperatures.
``The channel gene of pyrexia will open the door to developing new-concept medicines for brain damage in patients of high fever or drug addicts,’’ he said.
The channel gene refers to transport proteins, which provide a static passageway for a variety of essential substances to enter into cells.
``Up until now, a lot of channel genes activated by temperatures have been identified. But among them, pyrexia is first that guards brain nerves from external stresses,’’ Kim said.
Kim’s team learned pyrexia plays a pivotal role in the body through experiments with genetically engineered flies that did not have any pyrexia.
Up to 60 percent of the pyrexia-depleted mutants were paralyzed within three minutes of exposure to a temperature of 40 degrees Celsius.
In comparison, just 9 percent of normal flies were paralyzed with the same stimulus, indicating pyrexia is responsible for protecting animals from high-temperature stress.
``Our next goal is to develop pyrexia-embedded drugs, which can be expected to commercially debut in about five years,’’ Kim said.
Kim has already applied for international patents for his medical breakthrough, which will be printed in the March edition of Nature Genetics, a science journal.
voc200@koreatimes.co.kr
2005.02.02 View 16580
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Nerve-protecting gene discovered
Korean scientists for the first time have identified a gene that blocks nerve damage from fevers and the use of narcotics, a state-run research institute said yesterday.
The finding may open the way for new medicine that can prevent the loss of brain function which is frequently caused by excessive stimulation of nerves and abnormally high body temperature.
"The research is in an early stage. But this approach has the potential to develop genetics-based preventatives against brain-attacking diseases," said Kim Jae-seob, a bioscience professor of the Korea Advanced Institute of Science and Technology, who led the study.
The researchers named the gene Pyrexia, which means fever. Kim"s team extracted it from genetically engineered fruit flies using a genome-screening system. In laboratory tests, they found that the gene is activated to 39 degrees Celsius or higher.
The researchers enhanced Pyrexia"s functionality in some fruit flies while removing the gene from others to observe their different reactions when exposed to high temperature.
"The fruit flies without the gene showed severe nerve disorder and suffered paralysis of brain function, while Pyrexia-enhanced flies maintained their normal brain conditions," the professor said.
The researchers got the same result from experiments with human cells, he said.
There are a lot of channel proteins, which enable ions to enter and exit the cell, that react to the level of temperature, but Pyrexia is the first of its kind that actually protects the neurons from external stimulus, he said.
The finding will appear on the March edition of the London-based science magazine Nature Genetics.
THE KOREA HERALD 2005.1.31 (thkim@heraldm.com) By Kim Tong-hyung
2005.02.02 View 17190